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Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

Author

Listed:
  • Da Jia

    (Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA)

  • Renata Z. Jurkowska

    (Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Campus Ring 1)

  • Xing Zhang

    (Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA)

  • Albert Jeltsch

    (Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Campus Ring 1)

  • Xiaodong Cheng

    (Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA)

Abstract

A crystal structure of a complex between the DNA methyltransferase regulatory factor Dnmt3L and the catalytic domain of Dnmt3a leads to a model being proposed for the preferential methylation of DNA on maternally imprinted genes.

Suggested Citation

  • Da Jia & Renata Z. Jurkowska & Xing Zhang & Albert Jeltsch & Xiaodong Cheng, 2007. "Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation," Nature, Nature, vol. 449(7159), pages 248-251, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7159:d:10.1038_nature06146
    DOI: 10.1038/nature06146
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    Citations

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    Cited by:

    1. Naoki Kubo & Ryuji Uehara & Shuhei Uemura & Hiroaki Ohishi & Kenjiro Shirane & Hiroyuki Sasaki, 2024. "Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Linfeng Gao & Yiran Guo & Mahamaya Biswal & Jiuwei Lu & Jiekai Yin & Jian Fang & Xinyi Chen & Zengyu Shao & Mengjiang Huang & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2022. "Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Jiuwei Lu & Yiran Guo & Jiekai Yin & Jianbin Chen & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2024. "Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Jiyun Chen & Rong Hu & Ying Chen & Xiaofeng Lin & Wenwen Xiang & Hong Chen & Canglin Yao & Liang Liu, 2022. "Structural basis for MTA1c-mediated DNA N6-adenine methylation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Segal Mark R, 2008. "Re-Cracking the Nucleosome Positioning Code," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 7(1), pages 1-24, April.
    6. Gaolian Xu & Hao Yang & Jiani Qiu & Julien Reboud & Linqing Zhen & Wei Ren & Hong Xu & Jonathan M. Cooper & Hongchen Gu, 2023. "Sequence terminus dependent PCR for site-specific mutation and modification detection," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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