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Structural insight into autoinhibition and histone H3-induced activation of DNMT3A

Author

Listed:
  • Xue Guo

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University)

  • Ling Wang

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University)

  • Jie Li

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University)

  • Zhanyu Ding

    (National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Jianxiong Xiao

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University)

  • Xiaotong Yin

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University)

  • Shuang He

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University)

  • Pan Shi

    (High Magnetic Field Laboratory, Chinese Academy of Sciences
    National Laboratory for Physical Science at the Microscale, University of Science and Technology of China
    School of Life Sciences, University of Science and Technology of China)

  • Liping Dong

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science
    University of Chinese Academy of Science)

  • Guohong Li

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science)

  • Changlin Tian

    (High Magnetic Field Laboratory, Chinese Academy of Sciences
    National Laboratory for Physical Science at the Microscale, University of Science and Technology of China
    School of Life Sciences, University of Science and Technology of China)

  • Jiawei Wang

    (State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University)

  • Yao Cong

    (National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Yanhui Xu

    (Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University)

Abstract

A working model for histone H3-induced dynamic regulation of the de novo DNA methyltransferase.

Suggested Citation

  • Xue Guo & Ling Wang & Jie Li & Zhanyu Ding & Jianxiong Xiao & Xiaotong Yin & Shuang He & Pan Shi & Liping Dong & Guohong Li & Changlin Tian & Jiawei Wang & Yao Cong & Yanhui Xu, 2015. "Structural insight into autoinhibition and histone H3-induced activation of DNMT3A," Nature, Nature, vol. 517(7536), pages 640-644, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7536:d:10.1038_nature13899
    DOI: 10.1038/nature13899
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    Citations

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    Cited by:

    1. Naoki Kubo & Ryuji Uehara & Shuhei Uemura & Hiroaki Ohishi & Kenjiro Shirane & Hiroyuki Sasaki, 2024. "Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Athmane Teghanemt & Priyanjali Pulipati & Kara Misel-Wuchter & Kenneth Day & Matthew S. Yorek & Ren Yi & Henry L. Keen & Christy Au & Thorsten Maretzky & Prajwal Gurung & Dan R. Littman & Priya D. Iss, 2022. "CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Linfeng Gao & Yiran Guo & Mahamaya Biswal & Jiuwei Lu & Jiekai Yin & Jian Fang & Xinyi Chen & Zengyu Shao & Mengjiang Huang & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2022. "Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Seiichi Yano & Takashi Ishiuchi & Shusaku Abe & Satoshi H. Namekawa & Gang Huang & Yoshihiro Ogawa & Hiroyuki Sasaki, 2022. "Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Jiuwei Lu & Yiran Guo & Jiekai Yin & Jianbin Chen & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2024. "Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Xinyi Chen & Yiran Guo & Ting Zhao & Jiuwei Lu & Jian Fang & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2024. "Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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