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Volumetric additive manufacturing of pristine silk-based (bio)inks

Author

Listed:
  • Maobin Xie

    (Brigham and Women’s Hospital, Harvard Medical School
    The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital; School of Biomedical Engineering, Guangzhou Medical University)

  • Liming Lian

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Xuan Mu

    (Brigham and Women’s Hospital, Harvard Medical School
    Tufts University)

  • Zeyu Luo

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Carlos Ezio Garciamendez-Mijares

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Zhenrui Zhang

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Arturo López

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Jennifer Manríquez

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Xiao Kuang

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Junqi Wu

    (Tufts University)

  • Jugal Kishore Sahoo

    (Tufts University)

  • Federico Zertuche González

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Gang Li

    (Tufts University)

  • Guosheng Tang

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Sushila Maharjan

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Jie Guo

    (Brigham and Women’s Hospital, Harvard Medical School)

  • David L. Kaplan

    (Tufts University)

  • Yu Shrike Zhang

    (Brigham and Women’s Hospital, Harvard Medical School)

Abstract

Volumetric additive manufacturing (VAM) enables fast photopolymerization of three-dimensional constructs by illuminating dynamically evolving light patterns in the entire build volume. However, the lack of bioinks suitable for VAM is a critical limitation. This study reports rapid volumetric (bio)printing of pristine, unmodified silk-based (silk sericin (SS) and silk fibroin (SF)) (bio)inks to form sophisticated shapes and architectures. Of interest, combined with post-fabrication processing, the (bio)printed SS constructs reveal properties including reversible as well as repeated shrinkage and expansion, or shape-memory; whereas the (bio)printed SF constructs exhibit tunable mechanical performances ranging from a few hundred Pa to hundreds of MPa. Both types of silk-based (bio)inks are cytocompatible. This work supplies expanded bioink libraries for VAM and provides a path forward for rapid volumetric manufacturing of silk constructs, towards broadened biomedical applications.

Suggested Citation

  • Maobin Xie & Liming Lian & Xuan Mu & Zeyu Luo & Carlos Ezio Garciamendez-Mijares & Zhenrui Zhang & Arturo López & Jennifer Manríquez & Xiao Kuang & Junqi Wu & Jugal Kishore Sahoo & Federico Zertuche G, 2023. "Volumetric additive manufacturing of pristine silk-based (bio)inks," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35807-7
    DOI: 10.1038/s41467-023-35807-7
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    References listed on IDEAS

    as
    1. Linpeng Fan & Jing-Liang Li & Zengxiao Cai & Xungai Wang, 2021. "Bioactive hierarchical silk fibers created by bioinspired self-assembly," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    2. Damien Loterie & Paul Delrot & Christophe Moser, 2020. "High-resolution tomographic volumetric additive manufacturing," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
    3. Nan Qin & Zhi-Gang Qian & Chengzhe Zhou & Xiao-Xia Xia & Tiger H. Tao, 2021. "3D electron-beam writing at sub-15 nm resolution using spider silk as a resist," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    4. Soon Hee Kim & Yeung Kyu Yeon & Jung Min Lee & Janet Ren Chao & Young Jin Lee & Ye Been Seo & Md. Tipu Sultan & Ok Joo Lee & Ji Seung Lee & Sung-il Yoon & In-Sun Hong & Gilson Khang & Sang Jin Lee & J, 2018. "Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    5. John H. Martin & Brennan D. Yahata & Jacob M. Hundley & Justin A. Mayer & Tobias A. Schaedler & Tresa M. Pollock, 2017. "3D printing of high-strength aluminium alloys," Nature, Nature, vol. 549(7672), pages 365-369, September.
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