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Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing

Author

Listed:
  • Soon Hee Kim

    (Hallym University)

  • Yeung Kyu Yeon

    (Hallym University)

  • Jung Min Lee

    (Hallym University)

  • Janet Ren Chao

    (George Washington University)

  • Young Jin Lee

    (Hallym University)

  • Ye Been Seo

    (Hallym University)

  • Md. Tipu Sultan

    (Hallym University)

  • Ok Joo Lee

    (Hallym University)

  • Ji Seung Lee

    (Hallym University)

  • Sung-il Yoon

    (Kangwon National University)

  • In-Sun Hong

    (Gachon University)

  • Gilson Khang

    (Chonbuk National University)

  • Sang Jin Lee

    (Medical Center Boulevard)

  • James J. Yoo

    (Medical Center Boulevard)

  • Chan Hum Park

    (Hallym University
    Hallym University)

Abstract

Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution. The mechanical and rheological properties of Sil-MA hydrogel proved to be outstanding in experimental testing and can be modulated by varying the Sil-MA contents. This Sil-MA bioink allowed us to build highly complex organ structures, including the heart, vessel, brain, trachea and ear with excellent structural stability and reliable biocompatibility. Sil-MA bioink is well-suited for use in DLP printing process and could be applied to tissue and organ engineering depending on the specific biological requirements.

Suggested Citation

  • Soon Hee Kim & Yeung Kyu Yeon & Jung Min Lee & Janet Ren Chao & Young Jin Lee & Ye Been Seo & Md. Tipu Sultan & Ok Joo Lee & Ji Seung Lee & Sung-il Yoon & In-Sun Hong & Gilson Khang & Sang Jin Lee & J, 2018. "Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03759-y
    DOI: 10.1038/s41467-018-03759-y
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    Cited by:

    1. Milae Lee & Woojin Choi & Jeong Min Lee & Seung Tae Lee & Won-Gun Koh & Jinkee Hong, 2024. "Flavor-switchable scaffold for cultured meat with enhanced aromatic properties," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Jiayu Wu & Yuhuan Wang & Pan Jiang & Xiaolong Wang & Xin Jia & Feng Zhou, 2024. "Multiple hydrogen-bonding induced nonconventional red fluorescence emission in hydrogels," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Xihao Pan & Rui Li & Wenyue Li & Wei Sun & Yiyang Yan & Xiaochen Xiang & Jinghua Fang & Youguo Liao & Chang Xie & Xiaozhao Wang & Youzhi Cai & Xudong Yao & Hongwei Ouyang, 2024. "Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Soo Young Cho & Dong Hae Ho & Yoon Young Choi & Soomook Lim & Sungjoo Lee & Ji Won Suk & Sae Byeok Jo & Jeong Ho Cho, 2022. "A general fruit acid chelation route for eco-friendly and ambient 3D printing of metals," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    5. Maobin Xie & Liming Lian & Xuan Mu & Zeyu Luo & Carlos Ezio Garciamendez-Mijares & Zhenrui Zhang & Arturo López & Jennifer Manríquez & Xiao Kuang & Junqi Wu & Jugal Kishore Sahoo & Federico Zertuche G, 2023. "Volumetric additive manufacturing of pristine silk-based (bio)inks," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Ning He & Xiaonan Wang & Liyang Shi & Jing Li & Lan Mo & Feng Chen & Yuting Huang & Hairong Liu & Xiaolong Zhu & Wei Zhu & Yiqi Mao & Xiaoxiao Han, 2023. "Photoinhibiting via simultaneous photoabsorption and free-radical reaction for high-fidelity light-based bioprinting," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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