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Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears

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  • Xihao Pan

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine
    Zhejiang University School of Medicine
    China Orthopedic Regenerative Medicine Group (CORMed))

  • Rui Li

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Wenyue Li

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Wei Sun

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Yiyang Yan

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Xiaochen Xiang

    (Zhejiang University School of Medicine)

  • Jinghua Fang

    (Zhejiang University)

  • Youguo Liao

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Chang Xie

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Xiaozhao Wang

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine
    Zhejiang University School of Medicine
    China Orthopedic Regenerative Medicine Group (CORMed))

  • Youzhi Cai

    (School of Medicine, Zhejiang University)

  • Xudong Yao

    (International Institutes of Medicine, Zhejiang University School of Medicine)

  • Hongwei Ouyang

    (and Liangzhu Laboratory, Zhejiang University School of Medicine
    Zhejiang University School of Medicine
    Zhejiang University School of Medicine
    China Orthopedic Regenerative Medicine Group (CORMed))

Abstract

Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend meniscal repair tools from the perspective of adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrates chemo-mechanical restoration with inner meniscal regeneration. Supramolecular interactions of β-sheets and hydrogen bonds richened by phenylboronic acid-ionic liquid (PIL) result in enhanced wet adhesion, swelling resistance, and anti-fatigue capabilities, compared to neat silk fibroin gel. Besides, elimination of reactive oxygen species (ROS) by S-PIL10 further fortifies localized meniscus tear repair by affecting inflammatory microenvironment with dynamic borate ester bonds, and S-PIL10 continuously releases TGF-β1 for cell recruitment and bridging of defect edge. In vivo rabbit models functionally evidence the seamless and dense reconstruction of torn meniscus, verifying that the concept of meniscus adhesive is feasible and providing a promising revolutionary strategy for preclinical research to repair meniscus tears.

Suggested Citation

  • Xihao Pan & Rui Li & Wenyue Li & Wei Sun & Yiyang Yan & Xiaochen Xiang & Jinghua Fang & Youguo Liao & Chang Xie & Xiaozhao Wang & Youzhi Cai & Xudong Yao & Hongwei Ouyang, 2024. "Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47029-6
    DOI: 10.1038/s41467-024-47029-6
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    References listed on IDEAS

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    1. Yuanbo Jia & Jiahui Hu & Keli An & Qiang Zhao & Yang Dang & Hao Liu & Zhao Wei & Songmei Geng & Feng Xu, 2023. "Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yiming Ma & Jun Zhang & Yunqing Tian & Yihao Fu & Shu Tian & Qingsi Li & Jing Yang & Lei Zhang, 2023. "Zwitterionic microgel preservation platform for circulating tumor cells in whole blood specimen," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Hyunwoo Yuk & Claudia E. Varela & Christoph S. Nabzdyk & Xinyu Mao & Robert F. Padera & Ellen T. Roche & Xuanhe Zhao, 2019. "Dry double-sided tape for adhesion of wet tissues and devices," Nature, Nature, vol. 575(7781), pages 169-174, November.
    4. Soon Hee Kim & Yeung Kyu Yeon & Jung Min Lee & Janet Ren Chao & Young Jin Lee & Ye Been Seo & Md. Tipu Sultan & Ok Joo Lee & Ji Seung Lee & Sung-il Yoon & In-Sun Hong & Gilson Khang & Sang Jin Lee & J, 2018. "Publisher Correction: Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing," Nature Communications, Nature, vol. 9(1), pages 1-2, December.
    5. Jun Zhang & Wenxiang Wang & Yan Zhang & Qiang Wei & Fei Han & Shengyi Dong & Dongqing Liu & Shiguo Zhang, 2022. "Small-molecule ionic liquid-based adhesive with strong room-temperature adhesion promoted by electrostatic interaction," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    6. Soon Hee Kim & Yeung Kyu Yeon & Jung Min Lee & Janet Ren Chao & Young Jin Lee & Ye Been Seo & Md. Tipu Sultan & Ok Joo Lee & Ji Seung Lee & Sung-il Yoon & In-Sun Hong & Gilson Khang & Sang Jin Lee & J, 2018. "Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
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