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Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy

Author

Listed:
  • Rong Sun

    (Soochow University)

  • Mingzhu Liu

    (Soochow University)

  • Jianping Lu

    (Soochow University)

  • Binbin Chu

    (Soochow University)

  • Yunmin Yang

    (Soochow University)

  • Bin Song

    (Soochow University)

  • Houyu Wang

    (Soochow University)

  • Yao He

    (Soochow University)

Abstract

Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment of bacteria for combating central nervous system diseases. Herein, we develop a bacteria-based drug delivery system for glioblastoma (GBM) photothermal immunotherapy. The system, which we name as ‘Trojan bacteria’, consists of bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles. In an orthotopic GBM mouse model, we demonstrate that the intravenously injected bacteria bypass the BBB, targeting and penetrating GBM tissues. Upon 808 nm-laser irradiation, the photothermal effects produced by ICG allow the destruction of bacterial cells and the adjacent tumour cells. Furthermore, the bacterial debris as well as the tumour-associated antigens promote antitumor immune responses that prolong the survival of GBM-bearing mice. Moreover, we demonstrate the residual bacteria are effectively eliminated from the body, supporting the potential therapeutic use of this system.

Suggested Citation

  • Rong Sun & Mingzhu Liu & Jianping Lu & Binbin Chu & Yunmin Yang & Bin Song & Houyu Wang & Yao He, 2022. "Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32837-5
    DOI: 10.1038/s41467-022-32837-5
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    Cited by:

    1. Qian Zhang & Bin Song & Yanan Xu & Yunmin Yang & Jian Ji & Wenjun Cao & Jianping Lu & Jiali Ding & Haiting Cao & Binbin Chu & Jiaxu Hong & Houyu Wang & Yao He, 2023. "In vivo bioluminescence imaging of natural bacteria within deep tissues via ATP-binding cassette sugar transporter," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Ke-Fei Xu & Shun-Yu Wu & Zihao Wang & Yuxin Guo & Ya-Xuan Zhu & Chengcheng Li & Bai-Hui Shan & Xinping Zhang & Xiaoyang Liu & Fu-Gen Wu, 2024. "Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    3. Songlei Zhou & Yukun Huang & Yu Chen & Yipu Liu & Laozhi Xie & Yang You & Shiqiang Tong & Jianpei Xu & Gan Jiang & Qingxiang Song & Ni Mei & Fenfen Ma & Xiaoling Gao & Hongzhuan Chen & Jun Chen, 2023. "Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Imran Noorani & Jorge Rosa, 2023. "Breaking barriers for glioblastoma with a path to enhanced drug delivery," Nature Communications, Nature, vol. 14(1), pages 1-4, December.

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