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Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy

Author

Listed:
  • Ke-Fei Xu

    (Southeast University)

  • Shun-Yu Wu

    (Southeast University)

  • Zihao Wang

    (Southeast University)

  • Yuxin Guo

    (Southeast University)

  • Ya-Xuan Zhu

    (Tongji University School of Medicine)

  • Chengcheng Li

    (Nanjing Forestry University)

  • Bai-Hui Shan

    (Southeast University)

  • Xinping Zhang

    (Southeast University)

  • Xiaoyang Liu

    (Southeast University)

  • Fu-Gen Wu

    (Southeast University)

Abstract

Bacteria-mediated cancer therapeutic strategies have attracted increasing interest due to their intrinsic tumor tropism. However, bacteria-based drugs face several challenges including the large size of bacteria and dense extracellular matrix, limiting their intratumoral delivery efficiency. In this study, we find that hyperbaric oxygen (HBO), a noninvasive therapeutic method, can effectively deplete the dense extracellular matrix and thus enhance the bacterial accumulation within tumors. Inspired by this finding, we modify Escherichia coli Nissle 1917 (EcN) with cypate molecules to yield EcN-cypate for photothermal therapy, which can subsequently induce immunogenic cell death (ICD). Importantly, HBO treatment significantly increases the intratumoral accumulation of EcN-cypate and facilitates the intratumoral infiltration of immune cells to realize desirable tumor eradication through photothermal therapy and ICD-induced immunotherapy. Our work provides a facile and noninvasive strategy to enhance the intratumoral delivery efficiency of natural/engineered bacteria, and may promote the clinical translation of bacteria-mediated synergistic cancer therapy.

Suggested Citation

  • Ke-Fei Xu & Shun-Yu Wu & Zihao Wang & Yuxin Guo & Ya-Xuan Zhu & Chengcheng Li & Bai-Hui Shan & Xinping Zhang & Xiaoyang Liu & Fu-Gen Wu, 2024. "Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49156-6
    DOI: 10.1038/s41467-024-49156-6
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    References listed on IDEAS

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