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Breaking barriers for glioblastoma with a path to enhanced drug delivery

Author

Listed:
  • Imran Noorani

    (The Francis Crick Institute and University College London
    National Hospital for Neurology and Neurosurgery)

  • Jorge Rosa

    (University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus)

Abstract

Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB with nanoparticles boosts intratumoural chemotherapy concentration, prolonging survival. We discuss prospects for clinical translation of exemplary innovative techniques.

Suggested Citation

  • Imran Noorani & Jorge Rosa, 2023. "Breaking barriers for glioblastoma with a path to enhanced drug delivery," Nature Communications, Nature, vol. 14(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41694-9
    DOI: 10.1038/s41467-023-41694-9
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    References listed on IDEAS

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    1. Leila Ghanbari & Russell E. Carter & Mathew L. Rynes & Judith Dominguez & Gang Chen & Anant Naik & Jia Hu & Md Abdul Kader Sagar & Lenora Haltom & Nahom Mossazghi & Madelyn M. Gray & Sarah L. West & K, 2019. "Cortex-wide neural interfacing via transparent polymer skulls," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    2. Rong Sun & Mingzhu Liu & Jianping Lu & Binbin Chu & Yunmin Yang & Bin Song & Houyu Wang & Yao He, 2022. "Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Huan Chen & Ting Li & Zhiyong Liu & Shuwan Tang & Jintao Tong & Yingfang Tao & Zinan Zhao & Nan Li & Chun Mao & Jian Shen & Mimi Wan, 2023. "A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Qi Cai & Xiaoqing Li & Hejian Xiong & Hanwen Fan & Xiaofei Gao & Vamsidhara Vemireddy & Ryan Margolis & Junjie Li & Xiaoqian Ge & Monica Giannotta & Kenneth Hoyt & Elizabeth Maher & Robert Bachoo & Zh, 2023. "Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Jason V. Gregory & Padma Kadiyala & Robert Doherty & Melissa Cadena & Samer Habeel & Erkki Ruoslahti & Pedro R. Lowenstein & Maria G. Castro & Joerg Lahann, 2020. "Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
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