IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31989-8.html
   My bibliography  Save this article

UV photonic integrated circuits for far-field structured illumination autofluorescence microscopy

Author

Listed:
  • Chupao Lin

    (Ghent University-imec
    Ghent University)

  • Juan Santo Domingo Peñaranda

    (CoCooN, Ghent University)

  • Jolien Dendooven

    (CoCooN, Ghent University)

  • Christophe Detavernier

    (CoCooN, Ghent University)

  • David Schaubroeck

    (imec and Ghent University)

  • Nico Boon

    (Ghent University)

  • Roel Baets

    (Ghent University-imec
    Ghent University)

  • Nicolas Le Thomas

    (Ghent University-imec
    Ghent University)

Abstract

Ultra-violet (UV) light has still a limited scope in optical microscopy despite its potential advantages over visible light in terms of optical resolution and of interaction with a wide variety of biological molecules. The main challenge is to control in a robust, compact and cost-effective way UV light beams at the level of a single optical spatial mode and concomitantly to minimize the light propagation loss. To tackle this challenge, we present here photonic integrated circuits made of aluminum oxide thin layers that are compatible with both UV light and high-volume manufacturing. These photonic circuits designed at a wavelength of 360 nm enable super-resolved structured illumination microscopy with conventional wide-field microscopes and without modifying the usual protocol for handling the object to be imaged. As a biological application, we show that our UV photonic chips enable to image the autofluorescence of yeast cells and reveal features unresolved with standard wide-field microscopy.

Suggested Citation

  • Chupao Lin & Juan Santo Domingo Peñaranda & Jolien Dendooven & Christophe Detavernier & David Schaubroeck & Nico Boon & Roel Baets & Nicolas Le Thomas, 2022. "UV photonic integrated circuits for far-field structured illumination autofluorescence microscopy," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31989-8
    DOI: 10.1038/s41467-022-31989-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31989-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31989-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Wim Bogaerts & Daniel Pérez & José Capmany & David A. B. Miller & Joyce Poon & Dirk Englund & Francesco Morichetti & Andrea Melloni, 2020. "Programmable photonic circuits," Nature, Nature, vol. 586(7828), pages 207-216, October.
    2. Johann Riemensberger & Anton Lukashchuk & Maxim Karpov & Wenle Weng & Erwan Lucas & Junqiu Liu & Tobias J. Kippenberg, 2020. "Massively parallel coherent laser ranging using a soliton microcomb," Nature, Nature, vol. 581(7807), pages 164-170, May.
    3. Sami Koho & Giorgio Tortarolo & Marco Castello & Takahiro Deguchi & Alberto Diaspro & Giuseppe Vicidomini, 2019. "Fourier ring correlation simplifies image restoration in fluorescence microscopy," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sudip Shekhar & Wim Bogaerts & Lukas Chrostowski & John E. Bowers & Michael Hochberg & Richard Soref & Bhavin J. Shastri, 2024. "Roadmapping the next generation of silicon photonics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Mingming Nie & Kunpeng Jia & Yijun Xie & Shining Zhu & Zhenda Xie & Shu-Wei Huang, 2022. "Synthesized spatiotemporal mode-locking and photonic flywheel in multimode mesoresonators," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Okan Atalar & Raphaël Laer & Amir H. Safavi-Naeini & Amin Arbabian, 2022. "Longitudinal piezoelectric resonant photoelastic modulator for efficient intensity modulation at megahertz frequencies," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    4. Wenting Wang & Ping-Keng Lu & Abhinav Kumar Vinod & Deniz Turan & James F. McMillan & Hao Liu & Mingbin Yu & Dim-Lee Kwong & Mona Jarrahi & Chee Wei Wong, 2022. "Coherent terahertz radiation with 2.8-octave tunability through chip-scale photomixed microresonator optical parametric oscillation," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    5. H. H. Zhu & J. Zou & H. Zhang & Y. Z. Shi & S. B. Luo & N. Wang & H. Cai & L. X. Wan & B. Wang & X. D. Jiang & J. Thompson & X. S. Luo & X. H. Zhou & L. M. Xiao & W. Huang & L. Patrick & M. Gu & L. C., 2022. "Space-efficient optical computing with an integrated chip diffractive neural network," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    6. Yilun Li & Fang Huang, 2024. "A statistical resolution measure of fluorescence microscopy with finite photons," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    7. Yang Yang & Robert J. Chapman & Ben Haylock & Francesco Lenzini & Yogesh N. Joglekar & Mirko Lobino & Alberto Peruzzo, 2024. "Programmable high-dimensional Hamiltonian in a photonic waveguide array," Nature Communications, Nature, vol. 15(1), pages 1-7, December.
    8. Valeria Saggio & Carlos Errando-Herranz & Samuel Gyger & Christopher Panuski & Mihika Prabhu & Lorenzo Santis & Ian Christen & Dalia Ornelas-Huerta & Hamza Raniwala & Connor Gerlach & Marco Colangelo , 2024. "Cavity-enhanced single artificial atoms in silicon," Nature Communications, Nature, vol. 15(1), pages 1-6, December.
    9. Mark Dong & Julia M. Boyle & Kevin J. Palm & Matthew Zimmermann & Alex Witte & Andrew J. Leenheer & Daniel Dominguez & Gerald Gilbert & Matt Eichenfield & Dirk Englund, 2023. "Synchronous micromechanically resonant programmable photonic circuits," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    10. Xuguang Zhang & Zixuan Zhou & Yijun Guo & Minxue Zhuang & Warren Jin & Bitao Shen & Yujun Chen & Jiahui Huang & Zihan Tao & Ming Jin & Ruixuan Chen & Zhangfeng Ge & Zhou Fang & Ning Zhang & Yadong Liu, 2024. "High-coherence parallelization in integrated photonics," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    11. Kaihang Lu & Zengqi Chen & Hao Chen & Wu Zhou & Zunyue Zhang & Hon Ki Tsang & Yeyu Tong, 2024. "Empowering high-dimensional optical fiber communications with integrated photonic processors," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    12. Mehmet Berkay On & Farshid Ashtiani & David Sanchez-Jacome & Daniel Perez-Lopez & S. J. Ben Yoo & Andrea Blanco-Redondo, 2024. "Programmable integrated photonics for topological Hamiltonians," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    13. Han Zhao & Bingzhao Li & Huan Li & Mo Li, 2022. "Enabling scalable optical computing in synthetic frequency dimension using integrated cavity acousto-optics," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    14. Miltiadis Moralis-Pegios & George Giamougiannis & Apostolos Tsakyridis & David Lazovsky & Nikos Pleros, 2024. "Perfect linear optics using silicon photonics," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    15. Alessandro Rossetta & Eli Slenders & Mattia Donato & Sabrina Zappone & Francesco Fersini & Martina Bruno & Francesco Diotalevi & Luca Lanzanò & Sami Koho & Giorgio Tortarolo & Andrea Barberis & Marco , 2022. "The BrightEyes-TTM as an open-source time-tagging module for democratising single-photon microscopy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    16. Steven Becker & Dirk Englund & Birgit Stiller, 2024. "An optoacoustic field-programmable perceptron for recurrent neural networks," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    17. Grigory Lihachev & Wenle Weng & Junqiu Liu & Lin Chang & Joel Guo & Jijun He & Rui Ning Wang & Miles H. Anderson & Yang Liu & John E. Bowers & Tobias J. Kippenberg, 2022. "Platicon microcomb generation using laser self-injection locking," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    18. Ruobing Qian & Kevin C. Zhou & Jingkai Zhang & Christian Viehland & Al-Hafeez Dhalla & Joseph A. Izatt, 2022. "Video-rate high-precision time-frequency multiplexed 3D coherent ranging," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    19. Gregory Moille & Edgar F. Perez & Jordan R. Stone & Ashutosh Rao & Xiyuan Lu & Tahmid Sami Rahman & Yanne K. Chembo & Kartik Srinivasan, 2021. "Ultra-broadband Kerr microcomb through soliton spectral translation," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    20. Maoliang Wei & Kai Xu & Bo Tang & Junying Li & Yiting Yun & Peng Zhang & Yingchun Wu & Kangjian Bao & Kunhao Lei & Zequn Chen & Hui Ma & Chunlei Sun & Ruonan Liu & Ming Li & Lan Li & Hongtao Lin, 2024. "Monolithic back-end-of-line integration of phase change materials into foundry-manufactured silicon photonics," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31989-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.