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UV photonic integrated circuits for far-field structured illumination autofluorescence microscopy

Author

Listed:
  • Chupao Lin

    (Ghent University-imec
    Ghent University)

  • Juan Santo Domingo Peñaranda

    (CoCooN, Ghent University)

  • Jolien Dendooven

    (CoCooN, Ghent University)

  • Christophe Detavernier

    (CoCooN, Ghent University)

  • David Schaubroeck

    (imec and Ghent University)

  • Nico Boon

    (Ghent University)

  • Roel Baets

    (Ghent University-imec
    Ghent University)

  • Nicolas Le Thomas

    (Ghent University-imec
    Ghent University)

Abstract

Ultra-violet (UV) light has still a limited scope in optical microscopy despite its potential advantages over visible light in terms of optical resolution and of interaction with a wide variety of biological molecules. The main challenge is to control in a robust, compact and cost-effective way UV light beams at the level of a single optical spatial mode and concomitantly to minimize the light propagation loss. To tackle this challenge, we present here photonic integrated circuits made of aluminum oxide thin layers that are compatible with both UV light and high-volume manufacturing. These photonic circuits designed at a wavelength of 360 nm enable super-resolved structured illumination microscopy with conventional wide-field microscopes and without modifying the usual protocol for handling the object to be imaged. As a biological application, we show that our UV photonic chips enable to image the autofluorescence of yeast cells and reveal features unresolved with standard wide-field microscopy.

Suggested Citation

  • Chupao Lin & Juan Santo Domingo Peñaranda & Jolien Dendooven & Christophe Detavernier & David Schaubroeck & Nico Boon & Roel Baets & Nicolas Le Thomas, 2022. "UV photonic integrated circuits for far-field structured illumination autofluorescence microscopy," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31989-8
    DOI: 10.1038/s41467-022-31989-8
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    References listed on IDEAS

    as
    1. Wim Bogaerts & Daniel Pérez & José Capmany & David A. B. Miller & Joyce Poon & Dirk Englund & Francesco Morichetti & Andrea Melloni, 2020. "Programmable photonic circuits," Nature, Nature, vol. 586(7828), pages 207-216, October.
    2. Johann Riemensberger & Anton Lukashchuk & Maxim Karpov & Wenle Weng & Erwan Lucas & Junqiu Liu & Tobias J. Kippenberg, 2020. "Massively parallel coherent laser ranging using a soliton microcomb," Nature, Nature, vol. 581(7807), pages 164-170, May.
    3. Sami Koho & Giorgio Tortarolo & Marco Castello & Takahiro Deguchi & Alberto Diaspro & Giuseppe Vicidomini, 2019. "Fourier ring correlation simplifies image restoration in fluorescence microscopy," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
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