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Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Author

Listed:
  • Yong Kang

    (Tianjin University)

  • Zhuo Mao

    (Tianjin University)

  • Ying Wang

    (Sun Yat-sen University)

  • Chao Pan

    (Tianjin University)

  • Meitong Ou

    (Sun Yat-sen University)

  • Hanjie Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Weiwei Zeng

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Xiaoyuan Ji

    (Tianjin University)

Abstract

Limited substrates content is a major hurdle dampening the antitumor effect of catalytic therapy. Herein, a two-dimensional interplanar heterojunction (FeOCl/FeOOH NSs) with ·OH generation under ultrasound irradiation is fabricated and utilized for catalytic cancer therapy. This interplanar heterojunction is prepared through replacing chlorine from iron oxychloride with hydroxyl. Benefiting from the longer hydroxyl bond length and enhanced affinity with water, the alkali replacement treatment integrates interplanar heterojunction synthesis and exfoliation in one step. In particular, a build-in electric field facilitated Z-scheme interplanar heterojunction is formed due to the aligning Fermi levels. The holes on the valence band of FeOCl have great ability to catalyze O2 evolution from H2O, meanwhile, the generated O2 is immediately and directly reduced to H2O2 by the electrons on the conductive band of FeOOH. The self-supplying H2O2 ability guarantees efficient ·OH generation via the Fenton-like reaction catalyzed by FeOCl/FeOOH NSs, which exhibits excellent anti-tumor performance.

Suggested Citation

  • Yong Kang & Zhuo Mao & Ying Wang & Chao Pan & Meitong Ou & Hanjie Zhang & Weiwei Zeng & Xiaoyuan Ji, 2022. "Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30166-1
    DOI: 10.1038/s41467-022-30166-1
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    References listed on IDEAS

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    1. Xiaoyuan Ji & Lanlan Ge & Chuang Liu & Zhongmin Tang & Yufen Xiao & Wei Chen & Zhouyue Lei & Wei Gao & Sara Blake & Diba De & Bingyang Shi & Xiaobing Zeng & Na Kong & Xingcai Zhang & Wei Tao, 2021. "Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Minfeng Huo & Liying Wang & Yu Chen & Jianlin Shi, 2017. "Tumor-selective catalytic nanomedicine by nanocatalyst delivery," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    3. Na Kong & Hanjie Zhang & Chan Feng & Chuang Liu & Yufen Xiao & Xingcai Zhang & Lin Mei & Jong Seung Kim & Wei Tao & Xiaoyuan Ji, 2021. "Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    4. Yu-Jiung Lin & Imran Khan & Subhajit Saha & Chih-Cheng Wu & Snigdha Roy Barman & Fu-Cheng Kao & Zong-Hong Lin, 2021. "Thermocatalytic hydrogen peroxide generation and environmental disinfection by Bi2Te3 nanoplates," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
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    1. Hanjie Zhang & Yitong Zhang & Yushi Zhang & Hanyue Li & Meitong Ou & Yongkang Yu & Fan Zhang & Huijuan Yin & Zhuo Mao & Lin Mei, 2024. "Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Xue Yuan & Yong Kang & Jinrui Dong & Ruiyan Li & Jiamin Ye & Yueyue Fan & Jingwen Han & Junhui Yu & Guangjian Ni & Xiaoyuan Ji & Dong Ming, 2023. "Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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