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Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics

Author

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  • Xiaoyuan Ji

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School
    Tianjin University)

  • Lanlan Ge

    (Second Clinical Medical College of Jinan University
    Second Clinical Medical College of Jinan University
    Jinan University)

  • Chuang Liu

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School)

  • Zhongmin Tang

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School)

  • Yufen Xiao

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School)

  • Wei Chen

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School)

  • Zhouyue Lei

    (Harvard University)

  • Wei Gao

    (Harvard University)

  • Sara Blake

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School)

  • Diba De

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School)

  • Bingyang Shi

    (Henan University
    Macquarie University)

  • Xiaobing Zeng

    (Second Clinical Medical College of Jinan University)

  • Na Kong

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School)

  • Xingcai Zhang

    (Harvard University)

  • Wei Tao

    (Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School)

Abstract

Clay-based nanomaterials, especially 2:1 aluminosilicates such as vermiculite, biotite, and illite, have demonstrated great potential in various fields. However, their characteristic sandwiched structures and the lack of effective methods to exfoliate two-dimensional (2D) functional core layers (FCLs) greatly limit their future applications. Herein, we present a universal wet-chemical exfoliation method based on alkali etching that can intelligently “capture” the ultrathin and biocompatible FCLs (MgO and Fe2O3) sandwiched between two identical tetrahedral layers (SiO2 and Al2O3) from vermiculite. Without the sandwich structures that shielded their active sites, the obtained FCL nanosheets (NSs) exhibit a tunable and appropriate electron band structure (with the bandgap decreased from 2.0 eV to 1.4 eV), a conductive band that increased from −0.4 eV to −0.6 eV, and excellent light response characteristics. The great properties of 2D FCL NSs endow them with exciting potential in diverse applications including energy, photocatalysis, and biomedical engineering. This study specifically highlights their application in cancer theranostics as an example, potentially serving as a prelude to future extensive studies of 2D FCL NSs.

Suggested Citation

  • Xiaoyuan Ji & Lanlan Ge & Chuang Liu & Zhongmin Tang & Yufen Xiao & Wei Chen & Zhouyue Lei & Wei Gao & Sara Blake & Diba De & Bingyang Shi & Xiaobing Zeng & Na Kong & Xingcai Zhang & Wei Tao, 2021. "Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21436-5
    DOI: 10.1038/s41467-021-21436-5
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    Cited by:

    1. Bangfeng Wang & Yiwei Li & Mengfan Zhou & Yulong Han & Mingyu Zhang & Zhaolong Gao & Zetai Liu & Peng Chen & Wei Du & Xingcai Zhang & Xiaojun Feng & Bi-Feng Liu, 2023. "Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Weicheng Shen & Tingting Hu & Xueyan Liu & Jiajia Zha & Fanqi Meng & Zhikang Wu & Zhuolin Cui & Yu Yang & Hai Li & Qinghua Zhang & Lin Gu & Ruizheng Liang & Chaoliang Tan, 2022. "Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Zhiyang Zheng & Xiongwei Zhong & Qi Zhang & Mengtian Zhang & Lixin Dai & Xiao Xiao & Jiahe Xu & Miaolun Jiao & Boran Wang & Hong Li & Yeyang Jia & Rui Mao & Guangmin Zhou, 2024. "An extended substrate screening strategy enabling a low lattice mismatch for highly reversible zinc anodes," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Yongjiang Li & Wei Chen & Yong Kang & Xueyan Zhen & Zhuoming Zhou & Chuang Liu & Shuying Chen & Xiangang Huang & Hai-Jun Liu & Seyoung Koo & Na Kong & Xiaoyuan Ji & Tian Xie & Wei Tao, 2023. "Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Hualiang Lv & Yuxing Yao & Mingyue Yuan & Guanyu Chen & Yuchao Wang & Longjun Rao & Shucong Li & Ufuoma I. Kara & Robert L. Dupont & Cheng Zhang & Boyuan Chen & Bo Liu & Xiaodi Zhou & Renbing Wu & Sol, 2024. "Functional nanoporous graphene superlattice," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    6. Yong Kang & Zhuo Mao & Ying Wang & Chao Pan & Meitong Ou & Hanjie Zhang & Weiwei Zeng & Xiaoyuan Ji, 2022. "Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    7. Xue Yuan & Yong Kang & Jinrui Dong & Ruiyan Li & Jiamin Ye & Yueyue Fan & Jingwen Han & Junhui Yu & Guangjian Ni & Xiaoyuan Ji & Dong Ming, 2023. "Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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