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Systematic design of cell membrane coating to improve tumor targeting of nanoparticles

Author

Listed:
  • Lizhi Liu

    (University of Eastern Finland)

  • Dingyi Pan

    (Zhejiang University)

  • Sheng Chen

    (Yale University)

  • Maria-Viola Martikainen

    (University of Eastern Finland)

  • Anna Kårlund

    (University of Eastern Finland)

  • Jing Ke

    (Boston College)

  • Herkko Pulkkinen

    (University of Eastern Finland)

  • Hanna Ruhanen

    (University of Helsinki
    Helsinki University Lipidomics Unit (HiLIPID), Helsinki Institute of Life Science (HiLIFE) and Biocenter Finland)

  • Marjut Roponen

    (University of Eastern Finland)

  • Reijo Käkelä

    (University of Helsinki
    Helsinki University Lipidomics Unit (HiLIPID), Helsinki Institute of Life Science (HiLIFE) and Biocenter Finland)

  • Wujun Xu

    (University of Eastern Finland)

  • Jie Wang

    (Anhui Medical University)

  • Vesa-Pekka Lehto

    (University of Eastern Finland)

Abstract

Cell membrane (CM) coating technology is increasingly being applied in nanomedicine, but the entire coating procedure including adsorption, rupture, and fusion is not completely understood. Previously, we showed that the majority of biomimetic nanoparticles (NPs) were only partially coated, but the mechanism underlying this partial coating remains unclear, which hinders the further improvement of the coating technique. Here, we show that partial coating is an intermediate state due to the adsorption of CM fragments or CM vesicles, the latter of which could eventually be ruptured under external force. Such partial coating is difficult to self-repair to achieve full coating due to the limited membrane fluidity. Building on our understanding of the detailed coating process, we develop a general approach for fixing the partial CM coating: external phospholipid is introduced as a helper to increase CM fluidity, promoting the final fusion of lipid patches. The NPs coated with this approach have a high ratio of full coating (~23%) and exhibit enhanced tumor targeting ability in comparison to the NPs coated traditionally (full coating ratio of ~6%). Our results provide a mechanistic basis for fixing partial CM coating towards enhancing tumor accumulation.

Suggested Citation

  • Lizhi Liu & Dingyi Pan & Sheng Chen & Maria-Viola Martikainen & Anna Kårlund & Jing Ke & Herkko Pulkkinen & Hanna Ruhanen & Marjut Roponen & Reijo Käkelä & Wujun Xu & Jie Wang & Vesa-Pekka Lehto, 2022. "Systematic design of cell membrane coating to improve tumor targeting of nanoparticles," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33889-3
    DOI: 10.1038/s41467-022-33889-3
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    References listed on IDEAS

    as
    1. Na Kong & Hanjie Zhang & Chan Feng & Chuang Liu & Yufen Xiao & Xingcai Zhang & Lin Mei & Jong Seung Kim & Wei Tao & Xiaoyuan Ji, 2021. "Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    2. Motomu Tanaka & Erich Sackmann, 2005. "Polymer-supported membranes as models of the cell surface," Nature, Nature, vol. 437(7059), pages 656-663, September.
    3. Stephanie Ballweg & Erdinc Sezgin & Milka Doktorova & Roberto Covino & John Reinhard & Dorith Wunnicke & Inga Hänelt & Ilya Levental & Gerhard Hummer & Robert Ernst, 2020. "Regulation of lipid saturation without sensing membrane fluidity," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    4. Lizhi Liu & Xuan Bai & Maria-Viola Martikainen & Anna Kårlund & Marjut Roponen & Wujun Xu & Guoqing Hu & Ennio Tasciotti & Vesa-Pekka Lehto, 2021. "Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
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