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Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy

Author

Listed:
  • Na Kong

    (Harvard Medical School)

  • Hanjie Zhang

    (Tianjin University)

  • Chan Feng

    (Harvard Medical School)

  • Chuang Liu

    (Harvard Medical School)

  • Yufen Xiao

    (Harvard Medical School)

  • Xingcai Zhang

    (Harvard University)

  • Lin Mei

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jong Seung Kim

    (Korea University)

  • Wei Tao

    (Harvard Medical School)

  • Xiaoyuan Ji

    (Harvard Medical School
    Tianjin University)

Abstract

The modulation of intracellular reactive oxygen species (ROS) levels is crucial for cellular homeostasis and determination of cellular fate. A sublethal level of ROS sustains cell proliferation, differentiation and promotes tumor metastasis, while a drastic ROS burst directly induces apoptosis. Herein, surface-oxidized arsenene nanosheets (As/AsxOy NSs) with type II heterojunction are fabricated with efficient ·O2− and 1O2 production and glutathione consumption through prolonging the lifetime of photo-excited electron-hole pairs. Moreover, the portion of AsxOy with oxygen vacancies not only catalyzes a Fenton-like reaction, generating ·OH and O2 from H2O2, but also inactivates main anti-oxidants to cut off the “retreat routes” of ROS. After polydopamine (PDA) and cancer cell membrane (M) coating, the engineered As/AsxOy@PDA@M NSs serve as an intelligent theranostic platform with active tumor targeting and long-term blood circulation. Given its narrow-band-gap-enabled in vivo fluorescence imaging properties, As/AsxOy@PDA@M NSs could be applied as an imaging-guided non-invasive and real-time nanomedicine for cancer therapy.

Suggested Citation

  • Na Kong & Hanjie Zhang & Chan Feng & Chuang Liu & Yufen Xiao & Xingcai Zhang & Lin Mei & Jong Seung Kim & Wei Tao & Xiaoyuan Ji, 2021. "Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24961-5
    DOI: 10.1038/s41467-021-24961-5
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    Cited by:

    1. Weicheng Shen & Tingting Hu & Xueyan Liu & Jiajia Zha & Fanqi Meng & Zhikang Wu & Zhuolin Cui & Yu Yang & Hai Li & Qinghua Zhang & Lin Gu & Ruizheng Liang & Chaoliang Tan, 2022. "Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Lizhi Liu & Dingyi Pan & Sheng Chen & Maria-Viola Martikainen & Anna Kårlund & Jing Ke & Herkko Pulkkinen & Hanna Ruhanen & Marjut Roponen & Reijo Käkelä & Wujun Xu & Jie Wang & Vesa-Pekka Lehto, 2022. "Systematic design of cell membrane coating to improve tumor targeting of nanoparticles," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Yong Kang & Zhuo Mao & Ying Wang & Chao Pan & Meitong Ou & Hanjie Zhang & Weiwei Zeng & Xiaoyuan Ji, 2022. "Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    4. Xue Yuan & Yong Kang & Jinrui Dong & Ruiyan Li & Jiamin Ye & Yueyue Fan & Jingwen Han & Junhui Yu & Guangjian Ni & Xiaoyuan Ji & Dong Ming, 2023. "Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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