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Tumor-selective catalytic nanomedicine by nanocatalyst delivery

Author

Listed:
  • Minfeng Huo

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Liying Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    ShanghaiTech University)

  • Yu Chen

    (Chinese Academy of Sciences)

  • Jianlin Shi

    (Chinese Academy of Sciences)

Abstract

Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The resulting tumor microenvironment would provide characteristic physiochemical conditions for selective tumor modalities. Here we introduce a concept of sequential catalytic nanomedicine for efficient tumor therapy by designing and delivering biocompatible nanocatalysts into tumor sites. Natural glucose oxidase (GOD, enzyme catalyst) and ultrasmall Fe3O4 nanoparticles (inorganic nanozyme, Fenton reaction catalyst) have been integrated into the large pore-sized and biodegradable dendritic silica nanoparticles to fabricate the sequential nanocatalyst. GOD in sequential nanocatalyst could effectively deplete glucose in tumor cells, and meanwhile produce a considerable amount of H2O2 for subsequent Fenton-like reaction catalyzed by Fe3O4 nanoparticles in response to mild acidic tumor microenvironment. Highly toxic hydroxyl radicals are generated through these sequential catalytic reactions to trigger the apoptosis and death of tumor cells. The current work manifests a proof of concept of catalytic nanomedicine by approaching selectivity and efficiency concurrently for tumor therapeutics.

Suggested Citation

  • Minfeng Huo & Liying Wang & Yu Chen & Jianlin Shi, 2017. "Tumor-selective catalytic nanomedicine by nanocatalyst delivery," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00424-8
    DOI: 10.1038/s41467-017-00424-8
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    Cited by:

    1. Liu-Chun Wang & Pei-Yu Chiou & Ya-Ping Hsu & Chin-Lai Lee & Chih-Hsuan Hung & Yi-Hsuan Wu & Wen-Jyun Wang & Gia-Ling Hsieh & Ying-Chi Chen & Li-Chan Chang & Wen-Pin Su & Divinah Manoharan & Min-Chiao , 2023. "Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Shan Lei & Jing Zhang & Nicholas Thomas Blum & Meng Li & Dong-Yang Zhang & Weimin Yin & Feng Zhao & Jing Lin & Peng Huang, 2022. "In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Yawen You & Qingqing Deng & Yibo Wang & Yanjuan Sang & Guangming Li & Fang Pu & Jinsong Ren & Xiaogang Qu, 2022. "DNA-based platform for efficient and precisely targeted bioorthogonal catalysis in living systems," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Hanjie Zhang & Yitong Zhang & Yushi Zhang & Hanyue Li & Meitong Ou & Yongkang Yu & Fan Zhang & Huijuan Yin & Zhuo Mao & Lin Mei, 2024. "Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Yong Kang & Zhuo Mao & Ying Wang & Chao Pan & Meitong Ou & Hanjie Zhang & Weiwei Zeng & Xiaoyuan Ji, 2022. "Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    6. Jing Mu & Chunxiao Li & Yu Shi & Guoyong Liu & Jianhua Zou & Dong-Yang Zhang & Chao Jiang & Xiuli Wang & Liangcan He & Peng Huang & Yuxin Yin & Xiaoyuan Chen, 2022. "Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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