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Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

Author

Listed:
  • Xue Yuan

    (Tianjin University)

  • Yong Kang

    (Tianjin University)

  • Jinrui Dong

    (Tianjin University)

  • Ruiyan Li

    (Tianjin University)

  • Jiamin Ye

    (Tianjin University)

  • Yueyue Fan

    (Tianjin University)

  • Jingwen Han

    (Tianjin University)

  • Junhui Yu

    (Tianjin University)

  • Guangjian Ni

    (Tianjin University)

  • Xiaoyuan Ji

    (Tianjin University
    Linyi University)

  • Dong Ming

    (Tianjin University)

Abstract

The exogenous excitation requirement and electron-hole recombination are the key elements limiting the application of catalytic therapies. Here a tumor microenvironment (TME)-specific self-triggered thermoelectric nanoheterojunction (Bi0.5Sb1.5Te3/CaO2 nanosheets, BST/CaO2 NSs) with self-built-in electric field facilitated charge separation is fabricated. Upon exposure to TME, the CaO2 coating undergoes rapid hydrolysis, releasing Ca2+, H2O2, and heat. The resulting temperature difference on the BST NSs initiates a thermoelectric effect, driving reactive oxygen species production. H2O2 not only serves as a substrate supplement for ROS generation but also dysregulates Ca2+ channels, preventing Ca2+ efflux. This further exacerbates calcium overload-mediated therapy. Additionally, Ca2+ promotes DC maturation and tumor antigen presentation, facilitating immunotherapy. It is worth noting that the CaO2 NP coating hydrolyzes very slowly in normal cells, releasing Ca2+ and O2 without causing any adverse effects. Tumor-specific self-triggered thermoelectric nanoheterojunction combined catalytic therapy, ion interference therapy, and immunotherapy exhibit excellent antitumor performance in female mice.

Suggested Citation

  • Xue Yuan & Yong Kang & Jinrui Dong & Ruiyan Li & Jiamin Ye & Yueyue Fan & Jingwen Han & Junhui Yu & Guangjian Ni & Xiaoyuan Ji & Dong Ming, 2023. "Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40954-y
    DOI: 10.1038/s41467-023-40954-y
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    References listed on IDEAS

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    1. Xiaoyuan Ji & Lanlan Ge & Chuang Liu & Zhongmin Tang & Yufen Xiao & Wei Chen & Zhouyue Lei & Wei Gao & Sara Blake & Diba De & Bingyang Shi & Xiaobing Zeng & Na Kong & Xingcai Zhang & Wei Tao, 2021. "Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Na Kong & Hanjie Zhang & Chan Feng & Chuang Liu & Yufen Xiao & Xingcai Zhang & Lin Mei & Jong Seung Kim & Wei Tao & Xiaoyuan Ji, 2021. "Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
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    4. Yong Kang & Zhuo Mao & Ying Wang & Chao Pan & Meitong Ou & Hanjie Zhang & Weiwei Zeng & Xiaoyuan Ji, 2022. "Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
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    Cited by:

    1. Lu Yang & Zhiyu Zhao & Boshi Tian & Meiqi Yang & Yushan Dong & Bingchen Zhou & Shili Gai & Ying Xie & Jun Lin, 2024. "A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Hanjie Zhang & Yitong Zhang & Yushi Zhang & Hanyue Li & Meitong Ou & Yongkang Yu & Fan Zhang & Huijuan Yin & Zhuo Mao & Lin Mei, 2024. "Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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