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Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity

Author

Listed:
  • Yongjiang Li

    (Harvard Medical School)

  • Wei Chen

    (Harvard Medical School)

  • Yong Kang

    (Tianjin University)

  • Xueyan Zhen

    (Harvard Medical School)

  • Zhuoming Zhou

    (Harvard Medical School)

  • Chuang Liu

    (Harvard Medical School)

  • Shuying Chen

    (Harvard Medical School)

  • Xiangang Huang

    (Harvard Medical School)

  • Hai-Jun Liu

    (Harvard Medical School)

  • Seyoung Koo

    (Harvard Medical School)

  • Na Kong

    (Harvard Medical School
    Zhejiang University Medical Center
    Hangzhou Normal University)

  • Xiaoyuan Ji

    (Tianjin University
    Hangzhou Normal University)

  • Tian Xie

    (Hangzhou Normal University
    Hangzhou Normal University
    Hangzhou Normal University
    Hangzhou Normal University)

  • Wei Tao

    (Harvard Medical School)

Abstract

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy and the use of tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome the stromal barrier for the management of desmoplastic triple-negative breast cancer (TNBC). SnSNPs possess a narrow bandgap (1.18 eV), allowing for efficient electron (e−)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, SnSNPs display mild photothermal properties that can in situ denature tumor collagen and facilitate deep penetration into the tumor mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by SnSNPs and boosts antitumor immunity. In mouse models of malignant TNBC and hepatocellular carcinoma (HCC), the combination of robust SDT and enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. This study presents an innovative approach to enhance SDT and antitumor immunity using the denaturation-and-penetration strategy, offering a potential combined sono-immunotherapy approach for the cancer nanomedicine field.

Suggested Citation

  • Yongjiang Li & Wei Chen & Yong Kang & Xueyan Zhen & Zhuoming Zhou & Chuang Liu & Shuying Chen & Xiangang Huang & Hai-Jun Liu & Seyoung Koo & Na Kong & Xiaoyuan Ji & Tian Xie & Wei Tao, 2023. "Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42509-7
    DOI: 10.1038/s41467-023-42509-7
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    References listed on IDEAS

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    1. Xiaoyuan Ji & Lanlan Ge & Chuang Liu & Zhongmin Tang & Yufen Xiao & Wei Chen & Zhouyue Lei & Wei Gao & Sara Blake & Diba De & Bingyang Shi & Xiaobing Zeng & Na Kong & Xingcai Zhang & Wei Tao, 2021. "Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Fei Gong & Liang Cheng & Nailin Yang & Yuehan Gong & Yanwen Ni & Shang Bai & Xianwen Wang & Muchao Chen & Qian Chen & Zhuang Liu, 2020. "Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    3. Chi Zhang & Jingsheng Huang & Ziling Zeng & Shasha He & Penghui Cheng & Jingchao Li & Kanyi Pu, 2022. "Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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