IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-42509-7.html
   My bibliography  Save this article

Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity

Author

Listed:
  • Yongjiang Li

    (Harvard Medical School)

  • Wei Chen

    (Harvard Medical School)

  • Yong Kang

    (Tianjin University)

  • Xueyan Zhen

    (Harvard Medical School)

  • Zhuoming Zhou

    (Harvard Medical School)

  • Chuang Liu

    (Harvard Medical School)

  • Shuying Chen

    (Harvard Medical School)

  • Xiangang Huang

    (Harvard Medical School)

  • Hai-Jun Liu

    (Harvard Medical School)

  • Seyoung Koo

    (Harvard Medical School)

  • Na Kong

    (Harvard Medical School
    Zhejiang University Medical Center
    Hangzhou Normal University)

  • Xiaoyuan Ji

    (Tianjin University
    Hangzhou Normal University)

  • Tian Xie

    (Hangzhou Normal University
    Hangzhou Normal University
    Hangzhou Normal University
    Hangzhou Normal University)

  • Wei Tao

    (Harvard Medical School)

Abstract

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy and the use of tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome the stromal barrier for the management of desmoplastic triple-negative breast cancer (TNBC). SnSNPs possess a narrow bandgap (1.18 eV), allowing for efficient electron (e−)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, SnSNPs display mild photothermal properties that can in situ denature tumor collagen and facilitate deep penetration into the tumor mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by SnSNPs and boosts antitumor immunity. In mouse models of malignant TNBC and hepatocellular carcinoma (HCC), the combination of robust SDT and enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. This study presents an innovative approach to enhance SDT and antitumor immunity using the denaturation-and-penetration strategy, offering a potential combined sono-immunotherapy approach for the cancer nanomedicine field.

Suggested Citation

  • Yongjiang Li & Wei Chen & Yong Kang & Xueyan Zhen & Zhuoming Zhou & Chuang Liu & Shuying Chen & Xiangang Huang & Hai-Jun Liu & Seyoung Koo & Na Kong & Xiaoyuan Ji & Tian Xie & Wei Tao, 2023. "Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42509-7
    DOI: 10.1038/s41467-023-42509-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-42509-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-42509-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Xiaoyuan Ji & Lanlan Ge & Chuang Liu & Zhongmin Tang & Yufen Xiao & Wei Chen & Zhouyue Lei & Wei Gao & Sara Blake & Diba De & Bingyang Shi & Xiaobing Zeng & Na Kong & Xingcai Zhang & Wei Tao, 2021. "Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Fei Gong & Liang Cheng & Nailin Yang & Yuehan Gong & Yanwen Ni & Shang Bai & Xianwen Wang & Muchao Chen & Qian Chen & Zhuang Liu, 2020. "Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    3. Chi Zhang & Jingsheng Huang & Ziling Zeng & Shasha He & Penghui Cheng & Jingchao Li & Kanyi Pu, 2022. "Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Weicheng Shen & Tingting Hu & Xueyan Liu & Jiajia Zha & Fanqi Meng & Zhikang Wu & Zhuolin Cui & Yu Yang & Hai Li & Qinghua Zhang & Lin Gu & Ruizheng Liang & Chaoliang Tan, 2022. "Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Yong Kang & Zhuo Mao & Ying Wang & Chao Pan & Meitong Ou & Hanjie Zhang & Weiwei Zeng & Xiaoyuan Ji, 2022. "Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Bangfeng Wang & Yiwei Li & Mengfan Zhou & Yulong Han & Mingyu Zhang & Zhaolong Gao & Zetai Liu & Peng Chen & Wei Du & Xingcai Zhang & Xiaojun Feng & Bi-Feng Liu, 2023. "Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Zhiyang Zheng & Xiongwei Zhong & Qi Zhang & Mengtian Zhang & Lixin Dai & Xiao Xiao & Jiahe Xu & Miaolun Jiao & Boran Wang & Hong Li & Yeyang Jia & Rui Mao & Guangmin Zhou, 2024. "An extended substrate screening strategy enabling a low lattice mismatch for highly reversible zinc anodes," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Hualiang Lv & Yuxing Yao & Mingyue Yuan & Guanyu Chen & Yuchao Wang & Longjun Rao & Shucong Li & Ufuoma I. Kara & Robert L. Dupont & Cheng Zhang & Boyuan Chen & Bo Liu & Xiaodi Zhou & Renbing Wu & Sol, 2024. "Functional nanoporous graphene superlattice," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    6. Dongdong Wang & Jiawei Liu & Changlai Wang & Weiyun Zhang & Guangbao Yang & Yun Chen & Xiaodong Zhang & Yinglong Wu & Long Gu & Hongzhong Chen & Wei Yuan & Xiaokai Chen & Guofeng Liu & Bin Gao & Qianw, 2023. "Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Xue Yuan & Yong Kang & Jinrui Dong & Ruiyan Li & Jiamin Ye & Yueyue Fan & Jingwen Han & Junhui Yu & Guangjian Ni & Xiaoyuan Ji & Dong Ming, 2023. "Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    8. Bijiang Geng & Jinyan Hu & Yuan Li & Shini Feng & Dengyu Pan & Lingyan Feng & Longxiang Shen, 2022. "Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    9. Dongsheng Tang & Minhui Cui & Bin Wang & Ganghao Liang & Hanchen Zhang & Haihua Xiao, 2024. "Nanoparticles destabilizing the cell membranes triggered by NIR light for cancer imaging and photo-immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42509-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.