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Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography

Author

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  • Yinglong Wu

    (South China University of Technology)

  • Shuailing Huang

    (South China University of Technology)

  • Jun Wang

    (South China University of Technology)

  • Lihe Sun

    (South China University of Technology)

  • Fang Zeng

    (South China University of Technology)

  • Shuizhu Wu

    (South China University of Technology)

Abstract

Optoacoustic tomography (photoacoustic tomography) is an emerging imaging technology displaying great potential for medical diagnosis and preclinical research. Rationally designing activatable optoacoustic probes capable of diagnosing diseases and locating their foci can bring into full play the role of optoacoustic tomography (OAT) as a promising noninvasive imaging modality. Here we report two xanthene-based optoacoustic probes (C1X-OR1 and C2X-OR2) for temporospatial imaging of hepatic alkaline phosphatase (or β-galactosidase) for evaluating and locating drug-induced liver injury (or metastatic tumor). The probes rapidly respond to the disease-specific biomarkers by displaying red-shifted NIR absorption bands and generate prominent optoacoustic signals. Using multispectral optoacoustic tomography (MSOT), we can precisely localize the focus of drug-induced liver injury in mice using C1X-OR1, and the metastatic tumors using C2X-OR2. This work suggests that the activatable optoacoustic chromophores may potentially be applied for diagnosing and localizing disease foci, especially smaller and deeper ones.

Suggested Citation

  • Yinglong Wu & Shuailing Huang & Jun Wang & Lihe Sun & Fang Zeng & Shuizhu Wu, 2018. "Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06499-1
    DOI: 10.1038/s41467-018-06499-1
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    Cited by:

    1. Yinglong Wu & Lihe Sun & Xiaokai Chen & Jiawei Liu & Juan Ouyang & Xiaodong Zhang & Yi Guo & Yun Chen & Wei Yuan & Dongdong Wang & Ting He & Fang Zeng & Hongzhong Chen & Shuizhu Wu & Yanli Zhao, 2023. "Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Junjie Chen & Longqi Chen & Yinglong Wu & Yichang Fang & Fang Zeng & Shuizhu Wu & Yanli Zhao, 2021. "A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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