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Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Author

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  • Yuanyuan Li

    (The Hong Kong University of Science and Technology
    HKUST-Shenzhen Research Institute)

  • Zhaochong Cai

    (Zhejiang University)

  • Shunjie Liu

    (The Hong Kong University of Science and Technology
    HKUST-Shenzhen Research Institute)

  • Haoke Zhang

    (The Hong Kong University of Science and Technology)

  • Sherman T. H. Wong

    (The Hong Kong University of Science and Technology)

  • Jacky W. Y. Lam

    (The Hong Kong University of Science and Technology
    HKUST-Shenzhen Research Institute)

  • Ryan T. K. Kwok

    (The Hong Kong University of Science and Technology
    HKUST-Shenzhen Research Institute)

  • Jun Qian

    (Zhejiang University)

  • Ben Zhong Tang

    (The Hong Kong University of Science and Technology
    HKUST-Shenzhen Research Institute
    South China University of Technology
    Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet)

Abstract

Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose a molecular design philosophy to explore pure organic NIR-IIb fluorophores by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. An organic fluorescent dye emitting up to 1600 nm with a quantum yield of 11.5% in the NIR-II region is developed. NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved with high clarity and enhanced signal-to-background ratio. We hope this study will inspire further development on the evolution of pure organic NIR-IIb dyes for bio-imaging.

Suggested Citation

  • Yuanyuan Li & Zhaochong Cai & Shunjie Liu & Haoke Zhang & Sherman T. H. Wong & Jacky W. Y. Lam & Ryan T. K. Kwok & Jun Qian & Ben Zhong Tang, 2020. "Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15095-1
    DOI: 10.1038/s41467-020-15095-1
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    Cited by:

    1. Yulei Chang & Haoren Chen & Xiaoyu Xie & Yong Wan & Qiqing Li & Fengxia Wu & Run Yang & Wang Wang & Xianggui Kong, 2023. "Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Ani Baghdasaryan & Feifei Wang & Fuqiang Ren & Zhuoran Ma & Jiachen Li & Xueting Zhou & Lilit Grigoryan & Chun Xu & Hongjie Dai, 2022. "Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Junjie Chen & Longqi Chen & Yinglong Wu & Yichang Fang & Fang Zeng & Shuizhu Wu & Yanli Zhao, 2021. "A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Zhe Feng & Yuanyuan Li & Siyi Chen & Jin Li & Tianxiang Wu & Yanyun Ying & Junyan Zheng & Yuhuang Zhang & Jianquan Zhang & Xiaoxiao Fan & Xiaoming Yu & Dan Zhang & Ben Zhong Tang & Jun Qian, 2023. "Engineered NIR-II fluorophores with ultralong-distance molecular packing for high-contrast deep lesion identification," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Rui Tian & Xin Feng & Long Wei & Daoguo Dai & Ying Ma & Haifeng Pan & Shengxiang Ge & Lang Bai & Chaomin Ke & Yanlin Liu & Lixin Lang & Shoujun Zhu & Haitao Sun & Yanbao Yu & Xiaoyuan Chen, 2022. "A genetic engineering strategy for editing near-infrared-II fluorophores," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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