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Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing

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  • Lisha Yu

    (Zhejiang University
    Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province)

  • Zhaodi Liu

    (Zhejiang University
    Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province)

  • Yong Zheng

    (Zhejiang University)

  • Zongrui Tong

    (Zhejiang University
    Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province)

  • Yihang Ding

    (Zhejiang University)

  • Weilin Wang

    (Zhejiang University
    Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province
    Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province
    Ministry of Education)

  • Yuan Ding

    (Zhejiang University
    Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province
    Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province
    Ministry of Education)

  • Zhengwei Mao

    (Zhejiang University
    Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province
    Zhejiang University
    State Key Laboratory of Transvascular Implantation Devices)

Abstract

Uncontrolled haemorrhage is a leading cause of trauma-related fatalities, highlighting the critical need for rapid and effective haemostasis. Current haemostatic materials encounter limitations such as slow clotting and weak mechanical strength, while most of bioadhesives compromise their adhesion performance to wet tissues for biocompatibility and degradability. In this study, a molecular self-assembly strategy is proposed, developing a biocompatible and biodegradable protein-based patch with excellent adhesion performance. This strategy utilizes fibrinogen modified with hydrophobic groups to induce self-assembly into a hydrogel, which is converted into a dry patch. The protein patch enhances adhesion performance on the wet tissue through a dry cross-linking method and robust intra/inter-molecular interactions. This patch demonstrates excellent haemostatic efficacy in both porcine oozing wound and porcine severe acute haemorrhage. It maintains biological functionality, and ensures sustained wound sealing while gradually degrading in vivo, making it a promising candidate for clinical tissue sealing applications.

Suggested Citation

  • Lisha Yu & Zhaodi Liu & Yong Zheng & Zongrui Tong & Yihang Ding & Weilin Wang & Yuan Ding & Zhengwei Mao, 2025. "Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56726-9
    DOI: 10.1038/s41467-025-56726-9
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    References listed on IDEAS

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