IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-35907-4.html
   My bibliography  Save this article

A natural biological adhesive from snail mucus for wound repair

Author

Listed:
  • Tuo Deng

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Dongxiu Gao

    (Chinese Academy of Sciences
    Yunnan Minzu University)

  • Xuemei Song

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhipeng Zhou

    (Chinese Academy of Sciences)

  • Lixiao Zhou

    (Chinese Academy of Sciences
    Yunnan Minzu University)

  • Maixian Tao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zexiu Jiang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Lian Yang

    (Chinese Academy of Sciences)

  • Lan Luo

    (Chinese Academy of Sciences)

  • Ankun Zhou

    (Chinese Academy of Sciences)

  • Lin Hu

    (Yunnan Minzu University)

  • Hongbo Qin

    (Chinese Academy of Sciences
    Yunnan Minzu University)

  • Mingyi Wu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

The discovery of natural adhesion phenomena and mechanisms has advanced the development of a new generation of tissue adhesives in recent decades. In this study, we develop a natural biological adhesive from snail mucus gel, which consists a network of positively charged protein and polyanionic glycosaminoglycan. The malleable bulk adhesive matrix can adhere to wet tissue through multiple interactions. The biomaterial exhibits excellent haemostatic activity, biocompatibility and biodegradability, and it is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. Further mechanistic study shows it effectively promotes the polarization of macrophages towards the anti-inflammatory phenotype, alleviates inflammation in chronic wounds, and significantly improves epithelial regeneration and angiogenesis. Its abundant heparin-like glycosaminoglycan component is the main active ingredient. These findings provide theoretical and material insights into bio-inspired tissue adhesives and bioengineered scaffold designs.

Suggested Citation

  • Tuo Deng & Dongxiu Gao & Xuemei Song & Zhipeng Zhou & Lixiao Zhou & Maixian Tao & Zexiu Jiang & Lian Yang & Lan Luo & Ankun Zhou & Lin Hu & Hongbo Qin & Mingyi Wu, 2023. "A natural biological adhesive from snail mucus for wound repair," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35907-4
    DOI: 10.1038/s41467-023-35907-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-35907-4
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-35907-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kellar Autumn & Yiching A. Liang & S. Tonia Hsieh & Wolfgang Zesch & Wai Pang Chan & Thomas W. Kenny & Ronald Fearing & Robert J. Full, 2000. "Adhesive force of a single gecko foot-hair," Nature, Nature, vol. 405(6787), pages 681-685, June.
    2. Chao Ma & Jing Sun & Bo Li & Yang Feng & Yao Sun & Li Xiang & Baiheng Wu & Lingling Xiao & Baimei Liu & Vladislav S. Petrovskii & Liu & Jinrui Zhang & Zili Wang & Hongyan Li & Lei Zhang & Jingjing Li , 2021. "Ultra-strong bio-glue from genetically engineered polypeptides," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Bin Xue & Jie Gu & Lan Li & Wenting Yu & Sheng Yin & Meng Qin & Qing Jiang & Wei Wang & Yi Cao, 2021. "Hydrogel tapes for fault-tolerant strong wet adhesion," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Hyunwoo Yuk & Claudia E. Varela & Christoph S. Nabzdyk & Xinyu Mao & Robert F. Padera & Ellen T. Roche & Xuanhe Zhao, 2019. "Dry double-sided tape for adhesion of wet tissues and devices," Nature, Nature, vol. 575(7781), pages 169-174, November.
    5. Eric E. Leonhardt & Nari Kang & Mostafa A. Hamad & Karen L. Wooley & Mahmoud Elsabahy, 2019. "Absorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    6. Ovijit Chaudhuri & Justin Cooper-White & Paul A. Janmey & David J. Mooney & Vivek B. Shenoy, 2020. "Effects of extracellular matrix viscoelasticity on cellular behaviour," Nature, Nature, vol. 584(7822), pages 535-546, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ziheng Chen & Yibin Wang & Hui Chen & Junhui Law & Huayan Pu & Shaorong Xie & Feng Duan & Yu Sun & Na Liu & Jiangfan Yu, 2024. "A magnetic multi-layer soft robot for on-demand targeted adhesion," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Chengkun Zhao & Xing Li & Xiaowen Han & Zhulian Li & Shaoquan Bian & Weinan Zeng & Mingming Ding & Jie Liang & Qing Jiang & Zongke Zhou & Yujiang Fan & Xingdong Zhang & Yong Sun, 2024. "Molecular co-assembled strategy tuning protein conformation for cartilage regeneration," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Ming Li & Chenxi Wang & Qiang Yu & Haoyi Chen & Yingying Ma & Li Wei & Mei X. Wu & Min Yao & Min Lu, 2024. "A wearable and stretchable dual-wavelength LED device for home care of chronic infected wounds," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ran Yang & Xu Zhang & Binggang Chen & Qiuyan Yan & Jinghua Yin & Shifang Luan, 2023. "Tunable backbone-degradable robust tissue adhesives via in situ radical ring-opening polymerization," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Zhao Pan & Qi-Qi Fu & Mo-Han Wang & Huai-Ling Gao & Liang Dong & Pu Zhou & Dong-Dong Cheng & Ying Chen & Duo-Hong Zou & Jia-Cai He & Xue Feng & Shu-Hong Yu, 2023. "Designing nanohesives for rapid, universal, and robust hydrogel adhesion," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Feipeng Chen & Xiufeng Li & Yafeng Yu & Qingchuan Li & Haisong Lin & Lizhi Xu & Ho Cheung Shum, 2023. "Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Yujie Hua & Kai Wang & Yingying Huo & Yaping Zhuang & Yuhui Wang & Wenzhuo Fang & Yuyan Sun & Guangdong Zhou & Qiang Fu & Wenguo Cui & Kaile Zhang, 2023. "Four-dimensional hydrogel dressing adaptable to the urethral microenvironment for scarless urethral reconstruction," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Woojin Choi & Utkarsh Mangal & Jae-Hun Yu & Jeong-Hyun Ryu & Ji‑Yeong Kim & Taesuk Jun & Yoojin Lee & Heesu Cho & Moonhyun Choi & Milae Lee & Du Yeol Ryu & Sang-Young Lee & Se Yong Jung & Jae-Kook Cha, 2024. "Viscoelastic and antimicrobial dental care bioplastic with recyclable life cycle," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Yuanchi Zhang & Cairong Li & Along Guo & Yipei Yang & Yangyi Nie & Jiaxin Liao & Ben Liu & Yanmei Zhou & Long Li & Zhitong Chen & Wei Zhang & Ling Qin & Yuxiao Lai, 2024. "Black phosphorus boosts wet-tissue adhesion of composite patches by enhancing water absorption and mechanical properties," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    7. Guangyu Bao & Qiman Gao & Massimo Cau & Nabil Ali-Mohamad & Mitchell Strong & Shuaibing Jiang & Zhen Yang & Amin Valiei & Zhenwei Ma & Marco Amabili & Zu-Hua Gao & Luc Mongeau & Christian Kastrup & Ji, 2022. "Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Huimin He & Xi Wei & Bin Yang & Hongzhen Liu & Mingze Sun & Yanran Li & Aixin Yan & Chuyang Y. Tang & Yuan Lin & Lizhi Xu, 2022. "Ultrastrong and multifunctional aerogels with hyperconnective network of composite polymeric nanofibers," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    9. Parth Chansoria & Ameya Chaudhari & Emma L. Etter & Emily E. Bonacquisti & Mairead K. Heavey & Jiayan Le & Murali Kannan Maruthamuthu & Caden C. Kussatz & John Blackwell & Natalie E. Jasiewicz & Rani , 2024. "Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    10. Bin Xue & Jie Gu & Lan Li & Wenting Yu & Sheng Yin & Meng Qin & Qing Jiang & Wei Wang & Yi Cao, 2021. "Hydrogel tapes for fault-tolerant strong wet adhesion," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    11. Xiansheng Zhang & Hongwei Yan & Chongzhi Xu & Xia Dong & Yu Wang & Aiping Fu & Hao Li & Jin Yong Lee & Sheng Zhang & Jiahua Ni & Min Gao & Jing Wang & Jinpeng Yu & Shuzhi Sam Ge & Ming Liang Jin & Lil, 2023. "Skin-like cryogel electronics from suppressed-freezing tuned polymer amorphization," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    12. Camilo Duque Londono & Seth F. Cones & Jue Deng & Jingjing Wu & Hyunwoo Yuk & David E. Guza & T. Aran Mooney & Xuanhe Zhao, 2024. "Bioadhesive interface for marine sensors on diverse soft fragile species," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    13. Quanqian Lyu & Miaomiao Li & Lianbin Zhang & Jintao Zhu, 2024. "Structurally-colored adhesives for sensitive, high-resolution, and non-invasive adhesion self-monitoring," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    14. Jun Zhang & Wenxiang Wang & Yan Zhang & Qiang Wei & Fei Han & Shengyi Dong & Dongqing Liu & Shiguo Zhang, 2022. "Small-molecule ionic liquid-based adhesive with strong room-temperature adhesion promoted by electrostatic interaction," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    15. Chongrui Zhang & Xufei Liu & Jiang Gong & Qiang Zhao, 2023. "Liquid sculpture and curing of bio-inspired polyelectrolyte aqueous two-phase systems," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    16. Yangteng Ou & Shixiang Cao & Yang Zhang & Hongjia Zhu & Chengzhi Guo & Wei Yan & Fengxue Xin & Weiliang Dong & Yanli Zhang & Masashi Narita & Ziyi Yu & Tuomas P. J. Knowles, 2023. "Bioprinting microporous functional living materials from protein-based core-shell microgels," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    17. Farshad Farshidfar & Kahn Rhrissorrakrai & Chaya Levovitz & Cong Peng & James Knight & Antonella Bacchiocchi & Juan Su & Mingzhu Yin & Mario Sznol & Stephan Ariyan & James Clune & Kelly Olino & Laxmi , 2022. "Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    18. Hongmiao Tian & Duorui Wang & Yahui Zhang & Yuanze Jiang & Tianci Liu & Xiangming Li & Chunhui Wang & Xiaoliang Chen & Jinyou Shao, 2022. "Core–shell dry adhesives for rough surfaces via electrically responsive self-growing strategy," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    19. Roger A. Sauer, 2009. "Multiscale modelling and simulation of the deformation and adhesion of a single gecko seta," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(6), pages 627-640.
    20. Jing Sun & Haonan He & Kelu Zhao & Wenhao Cheng & Yuanxin Li & Peng Zhang & Sikang Wan & Yawei Liu & Mengyao Wang & Ming Li & Zheng Wei & Bo Li & Yi Zhang & Cong Li & Yao Sun & Jianlei Shen & Jingjing, 2023. "Protein fibers with self-recoverable mechanical properties via dynamic imine chemistry," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35907-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.