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A natural biological adhesive from snail mucus for wound repair

Author

Listed:
  • Tuo Deng

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Dongxiu Gao

    (Chinese Academy of Sciences
    Yunnan Minzu University)

  • Xuemei Song

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhipeng Zhou

    (Chinese Academy of Sciences)

  • Lixiao Zhou

    (Chinese Academy of Sciences
    Yunnan Minzu University)

  • Maixian Tao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zexiu Jiang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Lian Yang

    (Chinese Academy of Sciences)

  • Lan Luo

    (Chinese Academy of Sciences)

  • Ankun Zhou

    (Chinese Academy of Sciences)

  • Lin Hu

    (Yunnan Minzu University)

  • Hongbo Qin

    (Chinese Academy of Sciences
    Yunnan Minzu University)

  • Mingyi Wu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

The discovery of natural adhesion phenomena and mechanisms has advanced the development of a new generation of tissue adhesives in recent decades. In this study, we develop a natural biological adhesive from snail mucus gel, which consists a network of positively charged protein and polyanionic glycosaminoglycan. The malleable bulk adhesive matrix can adhere to wet tissue through multiple interactions. The biomaterial exhibits excellent haemostatic activity, biocompatibility and biodegradability, and it is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. Further mechanistic study shows it effectively promotes the polarization of macrophages towards the anti-inflammatory phenotype, alleviates inflammation in chronic wounds, and significantly improves epithelial regeneration and angiogenesis. Its abundant heparin-like glycosaminoglycan component is the main active ingredient. These findings provide theoretical and material insights into bio-inspired tissue adhesives and bioengineered scaffold designs.

Suggested Citation

  • Tuo Deng & Dongxiu Gao & Xuemei Song & Zhipeng Zhou & Lixiao Zhou & Maixian Tao & Zexiu Jiang & Lian Yang & Lan Luo & Ankun Zhou & Lin Hu & Hongbo Qin & Mingyi Wu, 2023. "A natural biological adhesive from snail mucus for wound repair," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35907-4
    DOI: 10.1038/s41467-023-35907-4
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    References listed on IDEAS

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    Cited by:

    1. Ziheng Chen & Yibin Wang & Hui Chen & Junhui Law & Huayan Pu & Shaorong Xie & Feng Duan & Yu Sun & Na Liu & Jiangfan Yu, 2024. "A magnetic multi-layer soft robot for on-demand targeted adhesion," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Chengkun Zhao & Xing Li & Xiaowen Han & Zhulian Li & Shaoquan Bian & Weinan Zeng & Mingming Ding & Jie Liang & Qing Jiang & Zongke Zhou & Yujiang Fan & Xingdong Zhang & Yong Sun, 2024. "Molecular co-assembled strategy tuning protein conformation for cartilage regeneration," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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