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Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage

Author

Listed:
  • Guangyu Bao

    (McGill University)

  • Qiman Gao

    (McGill University
    McGill University)

  • Massimo Cau

    (University of British Columbia)

  • Nabil Ali-Mohamad

    (University of British Columbia)

  • Mitchell Strong

    (McGill University)

  • Shuaibing Jiang

    (McGill University)

  • Zhen Yang

    (McGill University)

  • Amin Valiei

    (McGill University)

  • Zhenwei Ma

    (McGill University)

  • Marco Amabili

    (McGill University)

  • Zu-Hua Gao

    (University of British Columbia)

  • Luc Mongeau

    (McGill University)

  • Christian Kastrup

    (University of British Columbia
    Blood Research Institute, Versiti
    Division of Trauma and Acute Care Surgery, Medical College of Wisconsin
    Medical College of Wisconsin)

  • Jianyu Li

    (McGill University
    McGill University
    McGill University)

Abstract

Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function and integrity of hemostatic agents and the adhesion of bioadhesive sealants. Here, we report the design and performance of bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused with functional liquids. The xerogel can rapidly absorb interfacial fluids such as whole blood and promote blood clotting, while the infused liquids facilitate interfacial bonding, sealing, and antibacterial function. Their synergy enables the bioadhesives to form tough adhesion on ex vivo human and porcine tissues and diverse engineered surfaces without the need for compression, as well as on-demand instant removal and storage stability. We demonstrate a significantly improved hemostatic efficacy and biocompatibility in rats and pigs compared to non-structured counterparts and commercial products. This work opens new avenues for the development of bioadhesives and hemostatic sealants.

Suggested Citation

  • Guangyu Bao & Qiman Gao & Massimo Cau & Nabil Ali-Mohamad & Mitchell Strong & Shuaibing Jiang & Zhen Yang & Amin Valiei & Zhenwei Ma & Marco Amabili & Zu-Hua Gao & Luc Mongeau & Christian Kastrup & Ji, 2022. "Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32803-1
    DOI: 10.1038/s41467-022-32803-1
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    References listed on IDEAS

    as
    1. Xin Zhao & Baolin Guo & Hao Wu & Yongping Liang & Peter X. Ma, 2018. "Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    2. Jeong-Yun Sun & Xuanhe Zhao & Widusha R. K. Illeperuma & Ovijit Chaudhuri & Kyu Hwan Oh & David J. Mooney & Joost J. Vlassak & Zhigang Suo, 2012. "Highly stretchable and tough hydrogels," Nature, Nature, vol. 489(7414), pages 133-136, September.
    3. Xu Hou & Yuhang Hu & Alison Grinthal & Mughees Khan & Joanna Aizenberg, 2015. "Liquid-based gating mechanism with tunable multiphase selectivity and antifouling behaviour," Nature, Nature, vol. 519(7541), pages 70-73, March.
    4. Hyunwoo Yuk & Claudia E. Varela & Christoph S. Nabzdyk & Xinyu Mao & Robert F. Padera & Ellen T. Roche & Xuanhe Zhao, 2019. "Dry double-sided tape for adhesion of wet tissues and devices," Nature, Nature, vol. 575(7781), pages 169-174, November.
    5. Xinchen Du & Le Wu & Hongyu Yan & Zhuyan Jiang & Shilin Li & Wen Li & Yanli Bai & Hongjun Wang & Zhaojun Cheng & Deling Kong & Lianyong Wang & Meifeng Zhu, 2021. "Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
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    Cited by:

    1. Tianshen Jiang & Sirong Chen & Jingwen Xu & Yuxiao Zhang & Hao Fu & Qiangjun Ling & Yan Xu & Xiangyu Chu & Ruinan Wang & Liangcong Hu & Hao Li & Weitong Huang & Liming Bian & Pengchao Zhao & Fuxin Wei, 2024. "Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Sarah J. Wu & Jingjing Wu & Samuel J. Kaser & Heejung Roh & Ruth D. Shiferaw & Hyunwoo Yuk & Xuanhe Zhao, 2024. "A 3D printable tissue adhesive," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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