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Ultra-strong bio-glue from genetically engineered polypeptides

Author

Listed:
  • Chao Ma

    (Tsinghua University
    University of Groningen
    Harvard University)

  • Jing Sun

    (Harvard University
    Chinese Academy of Sciences)

  • Bo Li

    (Chinese Academy of Sciences)

  • Yang Feng

    (Chinese Academy of Sciences)

  • Yao Sun

    (Chinese Academy of Sciences)

  • Li Xiang

    (University of Alberta)

  • Baiheng Wu

    (Zhejiang University)

  • Lingling Xiao

    (Chinese Academy of Sciences)

  • Baimei Liu

    (Chinese Academy of Sciences)

  • Vladislav S. Petrovskii

    (Lomonosov Moscow State University
    Russian Academy of Sciences)

  • Liu

    (Chinese Academy of Sciences)

  • Jinrui Zhang

    (Chinese Academy of Sciences)

  • Zili Wang

    (Chinese Academy of Sciences)

  • Hongyan Li

    (University of Groningen
    DWI - Leibniz Institute for Interactive Materials)

  • Lei Zhang

    (Chinese Academy of Sciences)

  • Jingjing Li

    (Chinese Academy of Sciences)

  • Fan Wang

    (Chinese Academy of Sciences)

  • Robert Gӧstl

    (DWI - Leibniz Institute for Interactive Materials)

  • Igor I. Potemkin

    (Lomonosov Moscow State University
    DWI - Leibniz Institute for Interactive Materials
    National Research South Ural State University)

  • Dong Chen

    (Zhejiang University)

  • Hongbo Zeng

    (University of Alberta)

  • Hongjie Zhang

    (Tsinghua University
    Chinese Academy of Sciences)

  • Kai Liu

    (Tsinghua University
    Chinese Academy of Sciences)

  • Andreas Herrmann

    (University of Groningen
    DWI - Leibniz Institute for Interactive Materials
    RWTH Aachen University)

Abstract

The development of biomedical glues is an important, yet challenging task as seemingly mutually exclusive properties need to be combined in one material, i.e. strong adhesion and adaption to remodeling processes in healing tissue. Here, we report a biocompatible and biodegradable protein-based adhesive with high adhesion strengths. The maximum strength reaches 16.5 ± 2.2 MPa on hard substrates, which is comparable to that of commercial cyanoacrylate superglue and higher than other protein-based adhesives by at least one order of magnitude. Moreover, the strong adhesion on soft tissues qualifies the adhesive as biomedical glue outperforming some commercial products. Robust mechanical properties are realized without covalent bond formation during the adhesion process. A complex consisting of cationic supercharged polypeptides and anionic aromatic surfactants with lysine to surfactant molar ratio of 1:0.9 is driven by multiple supramolecular interactions enabling such strong adhesion. We demonstrate the glue’s robust performance in vitro and in vivo for cosmetic and hemostasis applications and accelerated wound healing by comparison to surgical wound closures.

Suggested Citation

  • Chao Ma & Jing Sun & Bo Li & Yang Feng & Yao Sun & Li Xiang & Baiheng Wu & Lingling Xiao & Baimei Liu & Vladislav S. Petrovskii & Liu & Jinrui Zhang & Zili Wang & Hongyan Li & Lei Zhang & Jingjing Li , 2021. "Ultra-strong bio-glue from genetically engineered polypeptides," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23117-9
    DOI: 10.1038/s41467-021-23117-9
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    Cited by:

    1. Jing Sun & Haonan He & Kelu Zhao & Wenhao Cheng & Yuanxin Li & Peng Zhang & Sikang Wan & Yawei Liu & Mengyao Wang & Ming Li & Zheng Wei & Bo Li & Yi Zhang & Cong Li & Yao Sun & Jianlei Shen & Jingjing, 2023. "Protein fibers with self-recoverable mechanical properties via dynamic imine chemistry," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Jun Zhang & Wenxiang Wang & Yan Zhang & Qiang Wei & Fei Han & Shengyi Dong & Dongqing Liu & Shiguo Zhang, 2022. "Small-molecule ionic liquid-based adhesive with strong room-temperature adhesion promoted by electrostatic interaction," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Chongrui Zhang & Xufei Liu & Jiang Gong & Qiang Zhao, 2023. "Liquid sculpture and curing of bio-inspired polyelectrolyte aqueous two-phase systems," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Ran Yang & Xu Zhang & Binggang Chen & Qiuyan Yan & Jinghua Yin & Shifang Luan, 2023. "Tunable backbone-degradable robust tissue adhesives via in situ radical ring-opening polymerization," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Yongchun Liu & Ke Li & Juanhua Tian & Aiting Gao & Lihua Tian & Hao Su & Shuting Miao & Fei Tao & Hao Ren & Qingmin Yang & Jing Cao & Peng Yang, 2023. "Synthesis of robust underwater glues from common proteins via unfolding-aggregating strategy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Xiaoming Xie & Yulian Jiang & Xiaoman Yao & Jiaqi Zhang & Zilin Zhang & Taoping Huang & Runhan Li & Yifa Chen & Shun-Li Li & Ya-Qian Lan, 2024. "A solvent-free processed low-temperature tolerant adhesive," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    7. Tuo Deng & Dongxiu Gao & Xuemei Song & Zhipeng Zhou & Lixiao Zhou & Maixian Tao & Zexiu Jiang & Lian Yang & Lan Luo & Ankun Zhou & Lin Hu & Hongbo Qin & Mingyi Wu, 2023. "A natural biological adhesive from snail mucus for wound repair," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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