IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-54374-z.html
   My bibliography  Save this article

Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus

Author

Listed:
  • Ju Sun

    (Shanxi Agricultural University
    Chinese Academy of Sciences (CAS))

  • Tianyi Zheng

    (Chinese Academy of Sciences (CAS))

  • Mingjun Jia

    (Shanxi Agricultural University
    Chinese Academy of Sciences (CAS))

  • Yanjun Wang

    (Chinese Academy of Sciences (CAS))

  • Jingru Yang

    (Chinese Academy of Sciences (CAS))

  • Yun Liu

    (Shanxi Agricultural University
    Chinese Academy of Sciences (CAS))

  • Pengyun Yang

    (Shanxi Agricultural University
    Chinese Academy of Sciences (CAS))

  • Yufeng Xie

    (Chinese Academy of Sciences (CAS))

  • Honglei Sun

    (China Agricultural University)

  • Qi Tong

    (China Agricultural University)

  • Jiaming Li

    (Chinese Academy of Sciences (CAS))

  • Jing Yang

    (Chinese Academy of Sciences (CAS))

  • Guanghua Fu

    (Fujian Academy of Agricultural Sciences)

  • Yi Shi

    (Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences)

  • Jianxun Qi

    (Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences)

  • Wenjun Liu

    (Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences)

  • Jinhua Liu

    (China Agricultural University)

  • Wen-xia Tian

    (Shanxi Agricultural University)

  • George F. Gao

    (Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences
    Zhejiang University)

  • Yuhai Bi

    (Shanxi Agricultural University
    Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences)

Abstract

The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in domestic poultry in China have genetic and antigenic differences compared to the A(H2N2)pdm1957. One H2N2 AIV has a dual receptor-binding property similar to that of the A(H2N2)pdm1957. Molecular and structural studies reveal that the N144S, and N144E or R137M substitutions in hemagglutinin (HA) enable H2N2 avian or human viruses to bind or preferentially bind human-type receptor. The H2N2 AIV rapidly adapts to mice (female) and acquires mammalian-adapted mutations that facilitated transmission in guinea pigs and ferrets (female). These findings on the receptor-binding, infectivity, transmission, and mammalian-adaptation characteristics of H2N2 AIVs provide a reference for early-warning and prevention for this subtype.

Suggested Citation

  • Ju Sun & Tianyi Zheng & Mingjun Jia & Yanjun Wang & Jingru Yang & Yun Liu & Pengyun Yang & Yufeng Xie & Honglei Sun & Qi Tong & Jiaming Li & Jing Yang & Guanghua Fu & Yi Shi & Jianxun Qi & Wenjun Liu , 2024. "Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54374-z
    DOI: 10.1038/s41467-024-54374-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-54374-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-54374-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Loïc Carrique & Haitian Fan & Alexander P. Walker & Jeremy R. Keown & Jane Sharps & Ecco Staller & Wendy S. Barclay & Ervin Fodor & Jonathan M. Grimes, 2020. "Host ANP32A mediates the assembly of the influenza virus replicase," Nature, Nature, vol. 587(7835), pages 638-643, November.
    2. Masaki Imai & Tokiko Watanabe & Masato Hatta & Subash C. Das & Makoto Ozawa & Kyoko Shinya & Gongxun Zhong & Anthony Hanson & Hiroaki Katsura & Shinji Watanabe & Chengjun Li & Eiryo Kawakami & Shinya , 2012. "Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets," Nature, Nature, vol. 486(7403), pages 420-428, June.
    3. Min Wang & Wei Zhang & Jianxun Qi & Fei Wang & Jianfang Zhou & Yuhai Bi & Ying Wu & Honglei Sun & Jinhua Liu & Chaobin Huang & Xiangdong Li & Jinghua Yan & Yuelong Shu & Yi Shi & George F. Gao, 2015. "Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus," Nature Communications, Nature, vol. 6(1), pages 1-7, May.
    4. Yuhai Bi & Juan Li & Shanqin Li & Guanghua Fu & Tao Jin & Cheng Zhang & Yongchun Yang & Zhenghai Ma & Wenxia Tian & Jida Li & Shuqi Xiao & Liqiang Li & Renfu Yin & Yi Zhang & Lixin Wang & Yantao Qin &, 2020. "Dominant subtype switch in avian influenza viruses during 2016–2019 in China," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ahmed Kandeil & Christopher Patton & Jeremy C. Jones & Trushar Jeevan & Walter N. Harrington & Sanja Trifkovic & Jon P. Seiler & Thomas Fabrizio & Karlie Woodard & Jasmine C. Turner & Jeri-Carol Crump, 2023. "Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Neng Xia & Dongdong Jin & Chengfeng Pan & Jiachen Zhang & Zhengxin Yang & Lin Su & Jinsheng Zhao & Liu Wang & Li Zhang, 2022. "Dynamic morphological transformations in soft architected materials via buckling instability encoded heterogeneous magnetization," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Zaolan Liang & Xia Lin & Lihong Sun & Kimberly M. Edwards & Wenjun Song & Hailiang Sun & Yanmin Xie & Fangmei Lin & Shiman Ling & Tingting Liang & Biying Xiao & Jiaqi Wang & Min Li & Chin-Yu Leung & H, 2024. "A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Kshitij Wagh & Aatish Bhatia & Benjamin D Greenbaum & Gyan Bhanot, 2014. "Bird to Human Transmission Biases and Vaccine Escape Mutants in H5N1 Infections," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-10, July.
    5. Oskar Staufer & Gösta Gantner & Ilia Platzman & Klaus Tanner & Imre Berger & Joachim P. Spatz, 2022. "Bottom-up assembly of viral replication cycles," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    6. Mansour Ebrahimi & Parisa Aghagolzadeh & Narges Shamabadi & Ahmad Tahmasebi & Mohammed Alsharifi & David L Adelson & Farhid Hemmatzadeh & Esmaeil Ebrahimie, 2014. "Understanding the Underlying Mechanism of HA-Subtyping in the Level of Physic-Chemical Characteristics of Protein," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-14, May.
    7. Hui Yang & Yurui Dong & Ying Bian & Nuo Xu & Yuwei Wu & Fan Yang & Yinping Du & Tao Qin & Sujuan Chen & Daxin Peng & Xiufan Liu, 2022. "The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    8. Jin Xie & Mohamed Ouizougun-Oubari & Li Wang & Guanglei Zhai & Daitze Wu & Zhaohu Lin & Manfu Wang & Barbara Ludeke & Xiaodong Yan & Tobias Nilsson & Lu Gao & Xinyi Huang & Rachel Fearns & Shuai Chen, 2024. "Structural basis for dimerization of a paramyxovirus polymerase complex," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    9. Katherine A. Amato & Luis A. Haddock & Katarina M. Braun & Victoria Meliopoulos & Brandi Livingston & Rebekah Honce & Grace A. Schaack & Emma Boehm & Christina A. Higgins & Gabrielle L. Barry & Katia , 2022. "Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    10. Mutsaers, Inge, 2015. "One-health approach as counter-measure against “autoimmune” responses in biosecurity," Social Science & Medicine, Elsevier, vol. 129(C), pages 123-130.
    11. Lu Xue & Tiancai Chang & Zimu Li & Chenchen Wang & Heyu Zhao & Mei Li & Peng Tang & Xin Wen & Mengmeng Yu & Jiqin Wu & Xichen Bao & Xiaojun Wang & Peng Gong & Jun He & Xinwen Chen & Xiaoli Xiong, 2024. "Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    12. Laura Matrajt & M Elizabeth Halloran & Ira M Longini Jr, 2013. "Optimal Vaccine Allocation for the Early Mitigation of Pandemic Influenza," PLOS Computational Biology, Public Library of Science, vol. 9(3), pages 1-15, March.
    13. Benoit Arragain & Martin Pelosse & Albert Thompson & Stephen Cusack, 2023. "Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    14. Yang Xue & Hanzhi Yu & Geng Qin, 2021. "Towards Good Governance on Dual-Use Biotechnology for Global Sustainable Development," Sustainability, MDPI, vol. 13(24), pages 1-14, December.
    15. Keng Boon Wee & Raphael Tze Chuen Lee & Jing Lin & Zacharias Aloysius Dwi Pramono & Sebastian Maurer-Stroh, 2016. "Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance," PLOS Computational Biology, Public Library of Science, vol. 12(1), pages 1-24, January.
    16. George J Milne & Nilimesh Halder & Joel K Kelso, 2013. "The Cost Effectiveness of Pandemic Influenza Interventions: A Pandemic Severity Based Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-16, April.
    17. Sarah C Kramer & Sen Pei & Jeffrey Shaman, 2020. "Forecasting influenza in Europe using a metapopulation model incorporating cross-border commuting and air travel," PLOS Computational Biology, Public Library of Science, vol. 16(10), pages 1-21, October.
    18. Daniel Malouli & Meenakshi Tiwary & Roxanne M. Gilbride & David W. Morrow & Colette M. Hughes & Andrea Selseth & Toni Penney & Priscila Castanha & Megan Wallace & Yulia Yeung & Morgan Midgett & Connor, 2024. "Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    19. Benoît Arragain & Quentin Durieux Trouilleton & Florence Baudin & Jan Provaznik & Nayara Azevedo & Stephen Cusack & Guy Schoehn & Hélène Malet, 2022. "Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    20. Min Wang & Yuan Gao & Chenguang Shen & Wei Yang & Qi Peng & Jinlong Cheng & Han-Ming Shen & Yang Yang & George Fu Gao & Yi Shi, 2024. "A human monoclonal antibody targeting the monomeric N6 neuraminidase confers protection against avian H5N6 influenza virus infection," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54374-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.