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Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

Author

Listed:
  • Masaki Imai

    (University of Wisconsin-Madison)

  • Tokiko Watanabe

    (University of Wisconsin-Madison
    ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan)

  • Masato Hatta

    (University of Wisconsin-Madison)

  • Subash C. Das

    (University of Wisconsin-Madison)

  • Makoto Ozawa

    (University of Wisconsin-Madison
    International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Kyoko Shinya

    (Kobe University, Hyogo 650-0017, Japan)

  • Gongxun Zhong

    (University of Wisconsin-Madison)

  • Anthony Hanson

    (University of Wisconsin-Madison)

  • Hiroaki Katsura

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Shinji Watanabe

    (University of Wisconsin-Madison
    ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan)

  • Chengjun Li

    (University of Wisconsin-Madison)

  • Eiryo Kawakami

    (ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan)

  • Shinya Yamada

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Maki Kiso

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Yasuo Suzuki

    (Health Science Hills, College of Life and Health Sciences, Chubu University, Kasugai, Aichi 487-8501, Japan)

  • Eileen A. Maher

    (University of Wisconsin-Madison)

  • Gabriele Neumann

    (University of Wisconsin-Madison)

  • Yoshihiro Kawaoka

    (University of Wisconsin-Madison
    ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan
    International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
    Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

Abstract

Only four mutations in H5N1 HA are required to enable ferret-to-ferret transmission of a reassortant virus containing the H5 HA and the remaining seven gene segments from a human pandemic H1N1 influenza virus.

Suggested Citation

  • Masaki Imai & Tokiko Watanabe & Masato Hatta & Subash C. Das & Makoto Ozawa & Kyoko Shinya & Gongxun Zhong & Anthony Hanson & Hiroaki Katsura & Shinji Watanabe & Chengjun Li & Eiryo Kawakami & Shinya , 2012. "Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets," Nature, Nature, vol. 486(7403), pages 420-428, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7403:d:10.1038_nature10831
    DOI: 10.1038/nature10831
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    Cited by:

    1. Katherine A. Amato & Luis A. Haddock & Katarina M. Braun & Victoria Meliopoulos & Brandi Livingston & Rebekah Honce & Grace A. Schaack & Emma Boehm & Christina A. Higgins & Gabrielle L. Barry & Katia , 2022. "Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Mansour Ebrahimi & Parisa Aghagolzadeh & Narges Shamabadi & Ahmad Tahmasebi & Mohammed Alsharifi & David L Adelson & Farhid Hemmatzadeh & Esmaeil Ebrahimie, 2014. "Understanding the Underlying Mechanism of HA-Subtyping in the Level of Physic-Chemical Characteristics of Protein," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-14, May.
    3. Kshitij Wagh & Aatish Bhatia & Benjamin D Greenbaum & Gyan Bhanot, 2014. "Bird to Human Transmission Biases and Vaccine Escape Mutants in H5N1 Infections," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-10, July.
    4. Daniel Malouli & Meenakshi Tiwary & Roxanne M. Gilbride & David W. Morrow & Colette M. Hughes & Andrea Selseth & Toni Penney & Priscila Castanha & Megan Wallace & Yulia Yeung & Morgan Midgett & Connor, 2024. "Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. George J Milne & Nilimesh Halder & Joel K Kelso, 2013. "The Cost Effectiveness of Pandemic Influenza Interventions: A Pandemic Severity Based Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-16, April.
    6. Keng Boon Wee & Raphael Tze Chuen Lee & Jing Lin & Zacharias Aloysius Dwi Pramono & Sebastian Maurer-Stroh, 2016. "Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance," PLOS Computational Biology, Public Library of Science, vol. 12(1), pages 1-24, January.
    7. Neng Xia & Dongdong Jin & Chengfeng Pan & Jiachen Zhang & Zhengxin Yang & Lin Su & Jinsheng Zhao & Liu Wang & Li Zhang, 2022. "Dynamic morphological transformations in soft architected materials via buckling instability encoded heterogeneous magnetization," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    8. Ahmed Kandeil & Christopher Patton & Jeremy C. Jones & Trushar Jeevan & Walter N. Harrington & Sanja Trifkovic & Jon P. Seiler & Thomas Fabrizio & Karlie Woodard & Jasmine C. Turner & Jeri-Carol Crump, 2023. "Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    9. Laura Matrajt & M Elizabeth Halloran & Ira M Longini Jr, 2013. "Optimal Vaccine Allocation for the Early Mitigation of Pandemic Influenza," PLOS Computational Biology, Public Library of Science, vol. 9(3), pages 1-15, March.
    10. Sarah C Kramer & Sen Pei & Jeffrey Shaman, 2020. "Forecasting influenza in Europe using a metapopulation model incorporating cross-border commuting and air travel," PLOS Computational Biology, Public Library of Science, vol. 16(10), pages 1-21, October.
    11. Oskar Staufer & Gösta Gantner & Ilia Platzman & Klaus Tanner & Imre Berger & Joachim P. Spatz, 2022. "Bottom-up assembly of viral replication cycles," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    12. Mutsaers, Inge, 2015. "One-health approach as counter-measure against “autoimmune” responses in biosecurity," Social Science & Medicine, Elsevier, vol. 129(C), pages 123-130.
    13. Yang Xue & Hanzhi Yu & Geng Qin, 2021. "Towards Good Governance on Dual-Use Biotechnology for Global Sustainable Development," Sustainability, MDPI, vol. 13(24), pages 1-14, December.

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