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Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus

Author

Listed:
  • Min Wang

    (College of Veterinary Medicine, China Agricultural University
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Wei Zhang

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Jianxun Qi

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Fei Wang

    (College of Veterinary Medicine, China Agricultural University
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Jianfang Zhou

    (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC))

  • Yuhai Bi

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Ying Wu

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Honglei Sun

    (College of Veterinary Medicine, China Agricultural University)

  • Jinhua Liu

    (College of Veterinary Medicine, China Agricultural University)

  • Chaobin Huang

    (State Key Laboratory of Agro-biotechnology, China Agricultural University)

  • Xiangdong Li

    (State Key Laboratory of Agro-biotechnology, China Agricultural University)

  • Jinghua Yan

    (College of Veterinary Medicine, China Agricultural University)

  • Yuelong Shu

    (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC))

  • Yi Shi

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences)

  • George F. Gao

    (College of Veterinary Medicine, China Agricultural University
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)
    Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences)

Abstract

Since December 2013, at least three cases of human infections with H10N8 avian influenza virus have been reported in China, two of them being fatal. To investigate the epidemic potential of H10N8 viruses, we examined the receptor binding property of the first human isolate, A/Jiangxi-Donghu/346/2013 (JD-H10N8), and determined the structures of its haemagglutinin (HA) in complex with both avian and human receptor analogues. Our results suggest that JD-H10N8 preferentially binds the avian receptor and that residue R137—localized within the receptor-binding site of HA—plays a key role in this preferential binding. Compared with the H7N9 avian influenza viruses, JD-H10N8 did not exhibit the enhanced binding to human receptors observed with the prevalent H7N9 virus isolate Anhui-1, but resembled the receptor binding activity of the early-outbreak H7N9 isolate (Shanghai-1). We conclude that the H10N8 virus is a typical avian influenza virus.

Suggested Citation

  • Min Wang & Wei Zhang & Jianxun Qi & Fei Wang & Jianfang Zhou & Yuhai Bi & Ying Wu & Honglei Sun & Jinhua Liu & Chaobin Huang & Xiangdong Li & Jinghua Yan & Yuelong Shu & Yi Shi & George F. Gao, 2015. "Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus," Nature Communications, Nature, vol. 6(1), pages 1-7, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6600
    DOI: 10.1038/ncomms6600
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    Cited by:

    1. Ju Sun & Tianyi Zheng & Mingjun Jia & Yanjun Wang & Jingru Yang & Yun Liu & Pengyun Yang & Yufeng Xie & Honglei Sun & Qi Tong & Jiaming Li & Jing Yang & Guanghua Fu & Yi Shi & Jianxun Qi & Wenjun Liu , 2024. "Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Min Wang & Yuan Gao & Chenguang Shen & Wei Yang & Qi Peng & Jinlong Cheng & Han-Ming Shen & Yang Yang & George Fu Gao & Yi Shi, 2024. "A human monoclonal antibody targeting the monomeric N6 neuraminidase confers protection against avian H5N6 influenza virus infection," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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