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Dominant subtype switch in avian influenza viruses during 2016–2019 in China

Author

Listed:
  • Yuhai Bi

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital)

  • Juan Li

    (Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences)

  • Shanqin Li

    (University of Chinese Academy of Sciences)

  • Guanghua Fu

    (Fujian Academy of Agricultural Sciences)

  • Tao Jin

    (China National Genebank-Shenzhen, BGI-Shenzhen)

  • Cheng Zhang

    (Chinese Academy of Sciences
    Xinjiang University)

  • Yongchun Yang

    (College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University)

  • Zhenghai Ma

    (Xinjiang University)

  • Wenxia Tian

    (Shanxi Agricultural University)

  • Jida Li

    (Zunyi Medical University)

  • Shuqi Xiao

    (Northwest A&F University)

  • Liqiang Li

    (China National Genebank-Shenzhen, BGI-Shenzhen)

  • Renfu Yin

    (Jilin University)

  • Yi Zhang

    (Zunyi Medical University)

  • Lixin Wang

    (Hainan Medical University)

  • Yantao Qin

    (Diqing Tibetan Autonomous Prefecture Centers for Disease Control and Prevention)

  • Zhongzi Yao

    (CASCIRE, Chinese Academy of Sciences)

  • Fanyu Meng

    (Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences)

  • Dongfang Hu

    (Henan Institute of Science and Technology)

  • Delong Li

    (Southwest University)

  • Gary Wong

    (Chinese Academy of Sciences
    Université Laval)

  • Fei Liu

    (Chinese Academy of Sciences)

  • Na Lv

    (Chinese Academy of Sciences)

  • Liang Wang

    (Chinese Academy of Sciences)

  • Lifeng Fu

    (Chinese Academy of Sciences)

  • Yang Yang

    (University of Chinese Academy of Sciences)

  • Yun Peng

    (University of Chinese Academy of Sciences)

  • Jinmin Ma

    (China National Genebank-Shenzhen, BGI-Shenzhen)

  • Kirill Sharshov

    (Novosibirsk State University)

  • Alexander Shestopalov

    (Novosibirsk State University)

  • Marina Gulyaeva

    (Novosibirsk State University)

  • George F. Gao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital
    Chinese Center for Disease Control and Prevention (China CDC))

  • Jianjun Chen

    (CASCIRE, Chinese Academy of Sciences)

  • Yi Shi

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • William J. Liu

    (Chinese Center for Disease Control and Prevention (China CDC))

  • Dong Chu

    (State Forestry and Grassland Administration)

  • Yu Huang

    (Fujian Academy of Agricultural Sciences)

  • Yingxia Liu

    (Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital)

  • Lei Liu

    (Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital)

  • Wenjun Liu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Quanjiao Chen

    (CASCIRE, Chinese Academy of Sciences)

  • Weifeng Shi

    (Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences
    Shandong First Medical University & Shandong Academy of Medical Sciences)

Abstract

We have surveyed avian influenza virus (AIV) genomes from live poultry markets within China since 2014. Here we present a total of 16,091 samples that were collected from May 2016 to February 2019 in 23 provinces and municipalities in China. We identify 2048 AIV-positive samples and perform next generation sequencing. AIV-positive rates (12.73%) from samples had decreased substantially since 2016, compared to that during 2014–2016 (26.90%). Additionally, H9N2 has replaced H5N6 and H7N9 as the dominant AIV subtype in both chickens and ducks. Notably, novel reassortants and variants continually emerged and disseminated in avian populations, including H7N3, H9N9, H9N6 and H5N6 variants. Importantly, almost all of the H9 AIVs and many H7N9 and H6N2 strains prefer human-type receptors, posing an increased risk for human infections. In summary, our nation-wide surveillance highlights substantial changes in the circulation of AIVs since 2016, which greatly impacts the prevention and control of AIVs in China and worldwide.

Suggested Citation

  • Yuhai Bi & Juan Li & Shanqin Li & Guanghua Fu & Tao Jin & Cheng Zhang & Yongchun Yang & Zhenghai Ma & Wenxia Tian & Jida Li & Shuqi Xiao & Liqiang Li & Renfu Yin & Yi Zhang & Lixin Wang & Yantao Qin &, 2020. "Dominant subtype switch in avian influenza viruses during 2016–2019 in China," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19671-3
    DOI: 10.1038/s41467-020-19671-3
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    Cited by:

    1. Zaolan Liang & Xia Lin & Lihong Sun & Kimberly M. Edwards & Wenjun Song & Hailiang Sun & Yanmin Xie & Fangmei Lin & Shiman Ling & Tingting Liang & Biying Xiao & Jiaqi Wang & Min Li & Chin-Yu Leung & H, 2024. "A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Ju Sun & Tianyi Zheng & Mingjun Jia & Yanjun Wang & Jingru Yang & Yun Liu & Pengyun Yang & Yufeng Xie & Honglei Sun & Qi Tong & Jiaming Li & Jing Yang & Guanghua Fu & Yi Shi & Jianxun Qi & Wenjun Liu , 2024. "Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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