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A human monoclonal antibody targeting the monomeric N6 neuraminidase confers protection against avian H5N6 influenza virus infection

Author

Listed:
  • Min Wang

    (Chinese Academy of Sciences (CAS)
    Shenzhen Third People’s Hospital)

  • Yuan Gao

    (Chinese Academy of Sciences (CAS)
    University of Macau)

  • Chenguang Shen

    (Shenzhen Third People’s Hospital
    School of Public Health; Southern Medical University)

  • Wei Yang

    (University of Chinese Academy of Sciences)

  • Qi Peng

    (Chinese Academy of Sciences (CAS))

  • Jinlong Cheng

    (Chinese Academy of Sciences (CAS))

  • Han-Ming Shen

    (University of Macau)

  • Yang Yang

    (Shenzhen Third People’s Hospital)

  • George Fu Gao

    (Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences
    Beijing Life Science Academy)

  • Yi Shi

    (Chinese Academy of Sciences (CAS)
    Shenzhen Third People’s Hospital
    University of Chinese Academy of Sciences
    Beijing Life Science Academy)

Abstract

The influenza neuraminidase (NA) is a potential target for the development of a next-generation influenza vaccine, but its antigenicity is not well understood. Here, we isolate an anti-N6 human monoclonal antibody, named 18_14D, from an H5N6 avian influenza virus (AIV) infected patient. The antibody weakly inhibits enzymatic activity but confers protection in female mice, mainly via ADCC function. The cryo-EM structure shows that 18_14D binds to a unique epitope on the lateral surface of the N6 tetramer, preventing the formation of tightly closed NA tetramers. These findings contribute to the molecular understanding of protective immune responses to NA of AIVs in humans and open an avenue for the rational design of NA-based vaccines.

Suggested Citation

  • Min Wang & Yuan Gao & Chenguang Shen & Wei Yang & Qi Peng & Jinlong Cheng & Han-Ming Shen & Yang Yang & George Fu Gao & Yi Shi, 2024. "A human monoclonal antibody targeting the monomeric N6 neuraminidase confers protection against avian H5N6 influenza virus infection," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53301-6
    DOI: 10.1038/s41467-024-53301-6
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    as
    1. Min Wang & Wei Zhang & Jianxun Qi & Fei Wang & Jianfang Zhou & Yuhai Bi & Ying Wu & Honglei Sun & Jinhua Liu & Chaobin Huang & Xiangdong Li & Jinghua Yan & Yuelong Shu & Yi Shi & George F. Gao, 2015. "Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus," Nature Communications, Nature, vol. 6(1), pages 1-7, May.
    2. Atsuhiro Yasuhara & Seiya Yamayoshi & Maki Kiso & Yuko Sakai-Tagawa & Moe Okuda & Yoshihiro Kawaoka, 2022. "A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
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