IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-53579-6.html
   My bibliography  Save this article

A wearable and stretchable dual-wavelength LED device for home care of chronic infected wounds

Author

Listed:
  • Ming Li

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Jiao Tong University School of Medicine)

  • Chenxi Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Qiang Yu

    (Shanghai Jiao Tong University School of Medicine)

  • Haoyi Chen

    (Shanghai Jiao Tong University School of Medicine)

  • Yingying Ma

    (Shanghai Jiao Tong University School of Medicine)

  • Li Wei

    (Shanghai Jiao Tong University School of Medicine)

  • Mei X. Wu

    (Harvard Medical School)

  • Min Yao

    (Shanghai Jiao Tong University School of Medicine)

  • Min Lu

    (Shanghai Jiao Tong University School of Medicine)

Abstract

Phototherapy can offer a safe and non-invasive solution against infections, while promoting wound healing. Conventional phototherapeutic devices are bulky and limited to hospital use. To overcome these challenges, we developed a wearable, flexible red and blue LED (r&bLED) patch controlled by a mobile-connected system, enabling safe self-application at home. The patch exhibits excellent skin compatibility, flexibility, and comfort, with high safety under system supervision. Additionally, we synthesized a sprayable fibrin gel (F-gel) containing blue light-sensitive thymoquinone and red light-synergistic NADH. Combined with bLED, thymoquinone eradicated microbes and biofilms within minutes, regardless of antibiotic resistance. Furthermore, NADH and rLED synergistically improved macrophage and endothelial cell mitochondrial function, promoting wound healing, reducing inflammation, and enhancing angiogenesis, as validated in infected diabetic wounds in mice and minipigs. This innovative technology holds great promise for revolutionizing at-home phototherapy for chronic infected wounds.

Suggested Citation

  • Ming Li & Chenxi Wang & Qiang Yu & Haoyi Chen & Yingying Ma & Li Wei & Mei X. Wu & Min Yao & Min Lu, 2024. "A wearable and stretchable dual-wavelength LED device for home care of chronic infected wounds," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53579-6
    DOI: 10.1038/s41467-024-53579-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-53579-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-53579-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Geming Lu & Ruihua Zhang & Shuo Geng & Liang Peng & Padmini Jayaraman & Chun Chen & Feifong Xu & Jianjun Yang & Qin Li & Hao Zheng & Kimberly Shen & Juan Wang & Xiyu Liu & Weidong Wang & Zihan Zheng &, 2015. "Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization," Nature Communications, Nature, vol. 6(1), pages 1-14, May.
    2. Jaewook Kim & Joonghyuk Kim & Yongjun Kim & Youngmok Son & Youngsik Shin & Hye Jin Bae & Ji Whan Kim & Sungho Nam & Yongsik Jung & Hyeonsu Kim & Sungwoo Kang & Yoonsoo Jung & Kyunghoon Lee & Hyeonho C, 2023. "Critical role of electrons in the short lifetime of blue OLEDs," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    3. Jinjian Huang & Rong Yang & Jiao Jiao & Ze Li & Penghui Wang & Ye Liu & Sicheng Li & Canwen Chen & Zongan Li & Guiwen Qu & Kang Chen & Xiuwen Wu & Bo Chi & Jianan Ren, 2023. "A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Eric D. Brown & Gerard D. Wright, 2016. "Antibacterial drug discovery in the resistance era," Nature, Nature, vol. 529(7586), pages 336-343, January.
    5. Tuo Deng & Dongxiu Gao & Xuemei Song & Zhipeng Zhou & Lixiao Zhou & Maixian Tao & Zexiu Jiang & Lian Yang & Lan Luo & Ankun Zhou & Lin Hu & Hongbo Qin & Mingyi Wu, 2023. "A natural biological adhesive from snail mucus for wound repair," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Li Yang & Dan Zhang & Wenjing Li & Hongbing Lin & Chendi Ding & Qingyun Liu & Liangliang Wang & Zimu Li & Lin Mei & Hongzhong Chen & Yanli Zhao & Xiaowei Zeng, 2023. "Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    7. Hongying Fu & Hengda Zhou & Xinghai Yu & Jingxiu Xu & Jinghua Zhou & Xinan Meng & Jianzhi Zhao & Yu Zhou & Andrew D. Chisholm & Suhong Xu, 2020. "Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jin Feng & Youle Zheng & Wanqing Ma & Defeng Weng & Dapeng Peng & Yindi Xu & Zhifang Wang & Xu Wang, 2024. "A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Kade D. Roberts & Yan Zhu & Mohammad A. K. Azad & Mei-Ling Han & Jiping Wang & Lynn Wang & Heidi H. Yu & Andrew S. Horne & Jo-Anne Pinson & David Rudd & Nicolas H. Voelcker & Nitin A. Patil & Jinxin Z, 2022. "A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Elsa Hansen & Jason Karslake & Robert J Woods & Andrew F Read & Kevin B Wood, 2020. "Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations," PLOS Biology, Public Library of Science, vol. 18(5), pages 1-20, May.
    4. Ziheng Chen & Yibin Wang & Hui Chen & Junhui Law & Huayan Pu & Shaorong Xie & Feng Duan & Yu Sun & Na Liu & Jiangfan Yu, 2024. "A magnetic multi-layer soft robot for on-demand targeted adhesion," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Qian Zhang & Bin Song & Yanan Xu & Yunmin Yang & Jian Ji & Wenjun Cao & Jianping Lu & Jiali Ding & Haiting Cao & Binbin Chu & Jiaxu Hong & Houyu Wang & Yao He, 2023. "In vivo bioluminescence imaging of natural bacteria within deep tissues via ATP-binding cassette sugar transporter," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Takeshi Nakaya & Miyuki Yabe & Ellene H. Mashalidis & Toyotaka Sato & Kazuki Yamamoto & Yuta Hikiji & Akira Katsuyama & Motoko Shinohara & Yusuke Minato & Satoshi Takahashi & Motohiro Horiuchi & Shin-, 2022. "Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    7. Hajkowicz, Stefan & Naughtin, Claire & Sanderson, Conrad & Schleiger, Emma & Karimi, Sarvnaz & Bratanova, Alexandra & Bednarz, Tomasz, 2022. "Artificial intelligence for science – adoption trends and future development pathways," MPRA Paper 115464, University Library of Munich, Germany.
    8. Chengkun Zhao & Xing Li & Xiaowen Han & Zhulian Li & Shaoquan Bian & Weinan Zeng & Mingming Ding & Jie Liang & Qing Jiang & Zongke Zhou & Yujiang Fan & Xingdong Zhang & Yong Sun, 2024. "Molecular co-assembled strategy tuning protein conformation for cartilage regeneration," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    9. Lianghui Cheng & Zhiyong Zhuang & Mingming Yin & Yuan Lu & Sujuan Liu & Minle Zhan & Liyuan Zhao & Zhenyan He & Fanling Meng & Sidan Tian & Liang Luo, 2024. "A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    10. Alberto Signoroni & Alessandro Ferrari & Stefano Lombardi & Mattia Savardi & Stefania Fontana & Karissa Culbreath, 2023. "Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    11. Chenyuan Wang & Yushan Xia & Runming Wang & Jingru Li & Chun-Lung Chan & Richard Yi-Tsun Kao & Patrick H. Toy & Pak-Leung Ho & Hongyan Li & Hongzhe Sun, 2023. "Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    12. Jiekai Sun & Xu Wang & Ye Gao & Shuangyu Li & Ziwei Hu & Yan Huang & Baoqiang Fan & Xia Wang & Miao Liu & Chunhua Qiao & Wei Zhang & Yipeng Wang & Xingyue Ji, 2024. "H2S scavenger as a broad-spectrum strategy to deplete bacteria-derived H2S for antibacterial sensitization," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    13. Sijia Guo & Shu Wang & Suze Ma & Zixin Deng & Wei Ding & Qi Zhang, 2022. "Radical SAM-dependent ether crosslink in daropeptide biosynthesis," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    14. Kelvin Ka-lok Wu & Xiaofan Xu & Manyin Wu & Xiaomu Li & Moinul Hoque & Gloria Hoi Yee Li & Qizhou Lian & Kekao Long & Tongxi Zhou & Hailong Piao & Aimin Xu & Hannah Xiaoyan Hui & Kenneth King-yip Chen, 2024. "MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    15. Asmalia Md-Lasim & Farah Shafawati Mohd-Taib & Mardani Abdul-Halim & Ahmad Mohiddin Mohd-Ngesom & Sheila Nathan & Shukor Md-Nor, 2021. "Leptospirosis and Coinfection: Should We Be Concerned?," IJERPH, MDPI, vol. 18(17), pages 1-17, September.
    16. Wei Li Thong & Yingxin Zhang & Ying Zhuo & Katherine J. Robins & Joanna K. Fyans & Abigail J. Herbert & Brian J. C. Law & Jason Micklefield, 2021. "Gene editing enables rapid engineering of complex antibiotic assembly lines," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    17. Hesam Aldin Varpaei & Mohammad Yavari & Mohammad Mahdi Miremami & Amir Mahdi Farahani & Faeze Esmaeili & Saba Abachi & Pariya Onsori & Pedram Nouroozi & Hossein Esmaeili & Ali Kazemi, 2020. "Epidemiological Study of Antibiotic Self-Medication in Tehran 1399, A Descriptive Study," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 31(1), pages 23870-23875, October.
    18. Zhiwen Liu & Kangli Guo & Liemei Yan & Kai Zhang & Ying Wang & Xiaokang Ding & Nana Zhao & Fu-Jian Xu, 2023. "Janus nanoparticles targeting extracellular polymeric substance achieve flexible elimination of drug-resistant biofilms," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    19. Kamal el Battioui & Sohini Chakraborty & András Wacha & Dániel Molnár & Mayra Quemé-Peña & Imola Cs. Szigyártó & Csenge Lilla Szabó & Andrea Bodor & Kata Horváti & Gergő Gyulai & Szilvia Bősze & Judit, 2024. "In situ captured antibacterial action of membrane-incising peptide lamellae," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53579-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.