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Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling

Author

Listed:
  • Hongying Fu

    (Zhejiang University School of Medicine)

  • Hengda Zhou

    (Zhejiang University School of Medicine
    The Zhejiang University-University of Edinburgh Institute)

  • Xinghai Yu

    (Wuhan University)

  • Jingxiu Xu

    (Zhejiang University School of Medicine
    The Zhejiang University-University of Edinburgh Institute)

  • Jinghua Zhou

    (Zhejiang University School of Medicine)

  • Xinan Meng

    (Zhejiang University School of Medicine)

  • Jianzhi Zhao

    (Zhejiang University School of Medicine)

  • Yu Zhou

    (Wuhan University)

  • Andrew D. Chisholm

    (University of California)

  • Suhong Xu

    (Zhejiang University School of Medicine
    The Zhejiang University-University of Edinburgh Institute
    Women’s Hospital of Zhejiang University, School of Medicine Hangzhou)

Abstract

Organisms respond to tissue damage through the upregulation of protective responses which restore tissue structure and metabolic function. Mitochondria are key sources of intracellular oxidative metabolic signals that maintain cellular homeostasis. Here we report that tissue and cellular wounding triggers rapid and reversible mitochondrial fragmentation. Elevated mitochondrial fragmentation either in fzo-1 fusion-defective mutants or after acute drug treatment accelerates actin-based wound closure. Wounding triggered mitochondrial fragmentation is independent of the GTPase DRP-1 but acts via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca2+. The fragmented mitochondria and accelerated wound closure of fzo-1 mutants are dependent on MIRO-1 function. Genetic and transcriptomic analyzes show that enhanced mitochondrial fragmentation accelerates wound closure via the upregulation of mtROS and Cytochrome P450. Our results reveal how mitochondrial dynamics respond to cellular and tissue injury and promote tissue repair.

Suggested Citation

  • Hongying Fu & Hengda Zhou & Xinghai Yu & Jingxiu Xu & Jinghua Zhou & Xinan Meng & Jianzhi Zhao & Yu Zhou & Andrew D. Chisholm & Suhong Xu, 2020. "Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14885-x
    DOI: 10.1038/s41467-020-14885-x
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    Cited by:

    1. Ming Li & Chenxi Wang & Qiang Yu & Haoyi Chen & Yingying Ma & Li Wei & Mei X. Wu & Min Yao & Min Lu, 2024. "A wearable and stretchable dual-wavelength LED device for home care of chronic infected wounds," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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