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Spindle-locked ripples mediate memory reactivation during human NREM sleep

Author

Listed:
  • Thomas Schreiner

    (Ludwig-Maximilians-Universität München)

  • Benjamin J. Griffiths

    (Ludwig-Maximilians-Universität München
    University of Birmingham)

  • Merve Kutlu

    (Ludwig-Maximilians-Universität München)

  • Christian Vollmar

    (Ludwig-Maximilians-Universität München)

  • Elisabeth Kaufmann

    (Ludwig-Maximilians-Universität München)

  • Stefanie Quach

    (University Hospital Munich, Ludwig-Maximilians-Universität München)

  • Jan Remi

    (Ludwig-Maximilians-Universität München)

  • Soheyl Noachtar

    (Ludwig-Maximilians-Universität München)

  • Tobias Staudigl

    (Ludwig-Maximilians-Universität München)

Abstract

Memory consolidation relies in part on the reactivation of previous experiences during sleep. The precise interplay of sleep-related oscillations (slow oscillations, spindles and ripples) is thought to coordinate the information flow between relevant brain areas, with ripples mediating memory reactivation. However, in humans empirical evidence for a role of ripples in memory reactivation is lacking. Here, we investigated the relevance of sleep oscillations and specifically ripples for memory reactivation during human sleep using targeted memory reactivation. Intracranial electrophysiology in epilepsy patients and scalp EEG in healthy participants revealed that elevated levels of slow oscillation - spindle activity coincided with the read-out of experimentally induced memory reactivation. Importantly, spindle-locked ripples recorded intracranially from the medial temporal lobe were found to be correlated with the identification of memory reactivation during non-rapid eye movement sleep. Our findings establish ripples as key-oscillation for sleep-related memory reactivation in humans and emphasize the importance of the coordinated interplay of the cardinal sleep oscillations.

Suggested Citation

  • Thomas Schreiner & Benjamin J. Griffiths & Merve Kutlu & Christian Vollmar & Elisabeth Kaufmann & Stefanie Quach & Jan Remi & Soheyl Noachtar & Tobias Staudigl, 2024. "Spindle-locked ripples mediate memory reactivation during human NREM sleep," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49572-8
    DOI: 10.1038/s41467-024-49572-8
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    References listed on IDEAS

    as
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