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Ramping dynamics and theta oscillations reflect dissociable signatures during rule-guided human behavior

Author

Listed:
  • Jan Weber

    (University Medical Center Tübingen
    University of Tübingen)

  • Anne-Kristin Solbakk

    (University of Oslo
    University of Oslo
    Oslo University Hospital
    Helgeland Hospital)

  • Alejandro O. Blenkmann

    (University of Oslo
    University of Oslo)

  • Anais Llorens

    (University of Oslo
    University of Oslo
    UC Berkeley)

  • Ingrid Funderud

    (University of Oslo
    University of Oslo
    Helgeland Hospital)

  • Sabine Leske

    (University of Oslo
    University of Oslo
    University of Oslo)

  • Pål Gunnar Larsson

    (Oslo University Hospital)

  • Jugoslav Ivanovic

    (Oslo University Hospital)

  • Robert T. Knight

    (UC Berkeley
    UC Berkeley)

  • Tor Endestad

    (University of Oslo
    University of Oslo)

  • Randolph F. Helfrich

    (University Medical Center Tübingen)

Abstract

Contextual cues and prior evidence guide human goal-directed behavior. The neurophysiological mechanisms that implement contextual priors to guide subsequent actions in the human brain remain unclear. Using intracranial electroencephalography (iEEG), we demonstrate that increasing uncertainty introduces a shift from a purely oscillatory to a mixed processing regime with an additional ramping component. Oscillatory and ramping dynamics reflect dissociable signatures, which likely differentially contribute to the encoding and transfer of different cognitive variables in a cue-guided motor task. The results support the idea that prefrontal activity encodes rules and ensuing actions in distinct coding subspaces, while theta oscillations synchronize the prefrontal-motor network, possibly to guide action execution. Collectively, our results reveal how two key features of large-scale neural population activity, namely continuous ramping dynamics and oscillatory synchrony, jointly support rule-guided human behavior.

Suggested Citation

  • Jan Weber & Anne-Kristin Solbakk & Alejandro O. Blenkmann & Anais Llorens & Ingrid Funderud & Sabine Leske & Pål Gunnar Larsson & Jugoslav Ivanovic & Robert T. Knight & Tor Endestad & Randolph F. Helf, 2024. "Ramping dynamics and theta oscillations reflect dissociable signatures during rule-guided human behavior," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44571-7
    DOI: 10.1038/s41467-023-44571-7
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