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Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents

Author

Listed:
  • Julie Seibt

    (Charité-Universitätsmedizin
    University of Surrey)

  • Clément J. Richard

    (Charité-Universitätsmedizin)

  • Johanna Sigl-Glöckner

    (Humboldt-Universitätzu Berlin)

  • Naoya Takahashi

    (Humboldt-Universität zu Berlin)

  • David I. Kaplan

    (Charité-Universitätsmedizin)

  • Guy Doron

    (Humboldt-Universität zu Berlin)

  • Denis Limoges

    (Universität Bern)

  • Christina Bocklisch

    (Humboldt-Universität zu Berlin)

  • Matthew E. Larkum

    (Humboldt-Universität zu Berlin)

Abstract

How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep. Here, we report that calcium activity in populations of neocortical dendrites is increased and synchronised during oscillations in the spindle range in naturally sleeping rodents. Remarkably, the same relationship is not found in cell bodies of the same neurons and throughout the cortical column. Spindles during sleep have been suggested to be important for brain development and plasticity. Our results provide evidence for a physiological link of spindles in the cortex specific to dendrites, the main site of synaptic plasticity.

Suggested Citation

  • Julie Seibt & Clément J. Richard & Johanna Sigl-Glöckner & Naoya Takahashi & David I. Kaplan & Guy Doron & Denis Limoges & Christina Bocklisch & Matthew E. Larkum, 2017. "Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00735-w
    DOI: 10.1038/s41467-017-00735-w
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    Cited by:

    1. Thomas Schreiner & Benjamin J. Griffiths & Merve Kutlu & Christian Vollmar & Elisabeth Kaufmann & Stefanie Quach & Jan Remi & Soheyl Noachtar & Tobias Staudigl, 2024. "Spindle-locked ripples mediate memory reactivation during human NREM sleep," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Laura Bojarskaite & Alexandra Vallet & Daniel M. Bjørnstad & Kristin M. Gullestad Binder & Céline Cunen & Kjell Heuser & Miroslav Kuchta & Kent-Andre Mardal & Rune Enger, 2023. "Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. I. Hristovska & M. Robert & K. Combet & J. Honnorat & J-C Comte & O. Pascual, 2022. "Sleep decreases neuronal activity control of microglial dynamics in mice," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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