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Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation

Author

Listed:
  • Celia M. Gagliardi

    (University of Iowa)

  • Marc E. Normandin

    (University of Iowa)

  • Alexandra T. Keinath

    (University of Illinois Chicago)

  • Joshua B. Julian

    (Princeton University)

  • Matthew R. Lopez

    (University of Iowa)

  • Manuel-Miguel Ramos-Alvarez

    (University of Jaen, Campus Las Lagunillas)

  • Russell A. Epstein

    (University of Pennsylvania)

  • Isabel A. Muzzio

    (University of Iowa)

Abstract

Reorientation, the process of regaining one’s bearings after becoming lost, requires identification of a spatial context (context recognition) and recovery of facing direction within that context (heading retrieval). We previously showed that these processes rely on the use of features and geometry, respectively. Here, we examine reorientation behavior in a task that creates contextual ambiguity over a long timescale to demonstrate that male mice learn to combine both featural and geometric cues to recover heading. At the neural level, most CA1 neurons persistently align to geometry, and this alignment predicts heading behavior. However, a small subset of cells remaps coherently in a context-sensitive manner, which serves to predict context. Efficient heading retrieval and context recognition correlate with rate changes reflecting integration of featural and geometric information in the active ensemble. These data illustrate how context recognition and heading retrieval are coded in CA1 and how these processes change with experience.

Suggested Citation

  • Celia M. Gagliardi & Marc E. Normandin & Alexandra T. Keinath & Joshua B. Julian & Matthew R. Lopez & Manuel-Miguel Ramos-Alvarez & Russell A. Epstein & Isabel A. Muzzio, 2024. "Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50112-7
    DOI: 10.1038/s41467-024-50112-7
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    1. Johannes Friedrich & Pengcheng Zhou & Liam Paninski, 2017. "Fast online deconvolution of calcium imaging data," PLOS Computational Biology, Public Library of Science, vol. 13(3), pages 1-26, March.
    2. Noguchi, Kimihiro & Gel, Yulia R. & Brunner, Edgar & Konietschke, Frank, 2012. "nparLD: An R Software Package for the Nonparametric Analysis of Longitudinal Data in Factorial Experiments," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 50(i12).
    3. Berens, Philipp, 2009. "CircStat: A MATLAB Toolbox for Circular Statistics," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 31(i10).
    4. John Huxter & Neil Burgess & John O'Keefe, 2003. "Independent rate and temporal coding in hippocampal pyramidal cells," Nature, Nature, vol. 425(6960), pages 828-832, October.
    5. Christian Ritz & Florent Baty & Jens C Streibig & Daniel Gerhard, 2015. "Dose-Response Analysis Using R," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-13, December.
    6. Konietschke, Frank & Placzek, Marius & Schaarschmidt, Frank & Hothorn, Ludwig A., 2015. "nparcomp: An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence Intervals," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 64(i09).
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