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Awake ripples enhance emotional memory encoding in the human brain

Author

Listed:
  • Haoxin Zhang

    (University of California Irvine
    University of California Irvine)

  • Ivan Skelin

    (Toronto Western Hospital, Toronto
    Department Center for Advancing Neurotechnological Innovation to Application, Toronto)

  • Shiting Ma

    (University of California Irvine)

  • Michelle Paff

    (University of California Irvine)

  • Lilit Mnatsakanyan

    (University of California Irvine)

  • Michael A. Yassa

    (University of California Irvine
    University of California Irvine
    University of California Irvine)

  • Robert T. Knight

    (University of California Berkeley
    University of California Berkeley)

  • Jack J. Lin

    (School of Medicine, University of California Davis
    University of California Davis)

Abstract

Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased awake ripples after encoding of emotional, compared to neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity is predictive of later memory discrimination. Ripple-locked stimulus similarity appears earlier in the amygdala than in hippocampus and mutual information analysis confirms amygdala influence on hippocampal activity. Finally, the joint ripple-locked stimulus similarity in the amygdala and hippocampus is predictive of correct memory discrimination. These findings provide electrophysiological evidence that post-encoding ripples enhance memory for emotional events.

Suggested Citation

  • Haoxin Zhang & Ivan Skelin & Shiting Ma & Michelle Paff & Lilit Mnatsakanyan & Michael A. Yassa & Robert T. Knight & Jack J. Lin, 2024. "Awake ripples enhance emotional memory encoding in the human brain," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44295-8
    DOI: 10.1038/s41467-023-44295-8
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