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The human thalamus orchestrates neocortical oscillations during NREM sleep

Author

Listed:
  • Thomas Schreiner

    (Ludwig-Maximilians-Universität München)

  • Elisabeth Kaufmann

    (Ludwig-Maximilians-Universität München)

  • Soheyl Noachtar

    (Ludwig-Maximilians-Universität München)

  • Jan-Hinnerk Mehrkens

    (Ludwig-Maximilians-Universität München)

  • Tobias Staudigl

    (Ludwig-Maximilians-Universität München)

Abstract

A hallmark of non-rapid eye movement sleep is the coordinated interplay of slow oscillations (SOs) and sleep spindles. Traditionally, a cortico-thalamo-cortical loop is suggested to coordinate these rhythms: neocortically-generated SOs trigger spindles in the thalamus that are projected back to neocortex. Here, we used intrathalamic recordings from human epilepsy patients to test this canonical interplay. We show that SOs in the anterior thalamus precede neocortical SOs (peak −50 ms), whereas concurrently-recorded SOs in the mediodorsal thalamus are led by neocortical SOs (peak +50 ms). Sleep spindles, detected in both thalamic nuclei, preceded their neocortical counterparts (peak −100 ms) and were initiated during early phases of thalamic SOs. Our findings indicate an active role of the anterior thalamus in organizing sleep rhythms in the neocortex and highlight the functional diversity of thalamic nuclei in humans. The thalamic coordination of sleep oscillations could have broad implications for the mechanisms underlying memory consolidation.

Suggested Citation

  • Thomas Schreiner & Elisabeth Kaufmann & Soheyl Noachtar & Jan-Hinnerk Mehrkens & Tobias Staudigl, 2022. "The human thalamus orchestrates neocortical oscillations during NREM sleep," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32840-w
    DOI: 10.1038/s41467-022-32840-w
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    References listed on IDEAS

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    1. Guillaume Viejo & Adrien Peyrache, 2020. "Precise coupling of the thalamic head-direction system to hippocampal ripples," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    2. Berens, Philipp, 2009. "CircStat: A MATLAB Toolbox for Circular Statistics," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 31(i10).
    3. Thomas Schreiner & Marit Petzka & Tobias Staudigl & Bernhard P. Staresina, 2021. "Endogenous memory reactivation during sleep in humans is clocked by slow oscillation-spindle complexes," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    4. Rachel A. Mak-McCully & Matthieu Rolland & Anna Sargsyan & Chris Gonzalez & Michel Magnin & Patrick Chauvel & Marc Rey & Hélène Bastuji & Eric Halgren, 2017. "Coordination of cortical and thalamic activity during non-REM sleep in humans," Nature Communications, Nature, vol. 8(1), pages 1-11, August.
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    Cited by:

    1. Thomas Schreiner & Benjamin J. Griffiths & Merve Kutlu & Christian Vollmar & Elisabeth Kaufmann & Stefanie Quach & Jan Remi & Soheyl Noachtar & Tobias Staudigl, 2024. "Spindle-locked ripples mediate memory reactivation during human NREM sleep," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Thomas Schreiner & Marit Petzka & Tobias Staudigl & Bernhard P. Staresina, 2023. "Respiration modulates sleep oscillations and memory reactivation in humans," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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