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The human claustrum tracks slow waves during sleep

Author

Listed:
  • Layton Lamsam

    (Yale University)

  • Brett Gu

    (Yale University)

  • Mingli Liang

    (Yale University)

  • George Sun

    (Yale University)

  • Kamren J. Khan

    (Yale University)

  • Kevin N. Sheth

    (Yale University
    Yale University)

  • Lawrence J. Hirsch

    (Yale University
    Yale University)

  • Christopher Pittenger

    (Yale University
    Yale University
    Yale University
    Yale University)

  • Alfred P. Kaye

    (Yale University
    Yale University
    VA National Center for PTSD)

  • John H. Krystal

    (Yale University
    Yale University
    Yale University
    VA National Center for PTSD)

  • Eyiyemisi C. Damisah

    (Yale University
    Yale University
    Yale University
    Yale University)

Abstract

Slow waves are a distinguishing feature of non-rapid-eye-movement (NREM) sleep, an evolutionarily conserved process critical for brain function. Non-human studies suggest that the claustrum, a small subcortical nucleus, coordinates slow waves. We show that, in contrast to neurons from other brain regions, claustrum neurons in the human brain increase their spiking activity and track slow waves during NREM sleep, suggesting that the claustrum plays a role in coordinating human sleep architecture.

Suggested Citation

  • Layton Lamsam & Brett Gu & Mingli Liang & George Sun & Kamren J. Khan & Kevin N. Sheth & Lawrence J. Hirsch & Christopher Pittenger & Alfred P. Kaye & John H. Krystal & Eyiyemisi C. Damisah, 2024. "The human claustrum tracks slow waves during sleep," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53477-x
    DOI: 10.1038/s41467-024-53477-x
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    References listed on IDEAS

    as
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