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Coordination of cortical and thalamic activity during non-REM sleep in humans

Author

Listed:
  • Rachel A. Mak-McCully

    (University of California)

  • Matthieu Rolland

    (University of California)

  • Anna Sargsyan

    (University of California)

  • Chris Gonzalez

    (University of California)

  • Michel Magnin

    (Central Integration of Pain, Lyon Neuroscience Research Center, INSERM, U1028; CNRS, UMR5292; Université Claude Bernard)

  • Patrick Chauvel

    (Aix-Marseille Université
    INSERM, Institut de Neurosciences des Systèmes UMR 1106
    APHM (Assistance Publique–Hôpitaux de Marseille), Timone Hospital)

  • Marc Rey

    (Aix-Marseille Université
    INSERM, Institut de Neurosciences des Systèmes UMR 1106
    APHM (Assistance Publique–Hôpitaux de Marseille), Timone Hospital)

  • Hélène Bastuji

    (Central Integration of Pain, Lyon Neuroscience Research Center, INSERM, U1028; CNRS, UMR5292; Université Claude Bernard
    Unité d’Hypnologie, Service de Neurologie Fonctionnelle et d’Épileptologie, Hôpital Neurologique, Hospices Civils de Lyon)

  • Eric Halgren

    (University of California
    University of California
    University of California)

Abstract

Every night, the human brain produces thousands of downstates and spindles during non-REM sleep. Previous studies indicate that spindles originate thalamically and downstates cortically, loosely grouping spindle occurrence. However, the mechanisms whereby the thalamus and cortex interact in generating these sleep phenomena remain poorly understood. Using bipolar depth recordings, we report here a sequence wherein: (1) convergent cortical downstates lead thalamic downstates; (2) thalamic downstates hyperpolarize thalamic cells, thus triggering spindles; and (3) thalamic spindles are focally projected back to cortex, arriving during the down-to-upstate transition when the cortex replays memories. Thalamic intrinsic currents, therefore, may not be continuously available during non-REM sleep, permitting the cortex to control thalamic spindling by inducing downstates. This archetypical cortico-thalamo-cortical sequence could provide the global physiological context for memory consolidation during non-REM sleep.

Suggested Citation

  • Rachel A. Mak-McCully & Matthieu Rolland & Anna Sargsyan & Chris Gonzalez & Michel Magnin & Patrick Chauvel & Marc Rey & Hélène Bastuji & Eric Halgren, 2017. "Coordination of cortical and thalamic activity during non-REM sleep in humans," Nature Communications, Nature, vol. 8(1), pages 1-11, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15499
    DOI: 10.1038/ncomms15499
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    Cited by:

    1. Thomas Schreiner & Benjamin J. Griffiths & Merve Kutlu & Christian Vollmar & Elisabeth Kaufmann & Stefanie Quach & Jan Remi & Soheyl Noachtar & Tobias Staudigl, 2024. "Spindle-locked ripples mediate memory reactivation during human NREM sleep," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Thomas Schreiner & Elisabeth Kaufmann & Soheyl Noachtar & Jan-Hinnerk Mehrkens & Tobias Staudigl, 2022. "The human thalamus orchestrates neocortical oscillations during NREM sleep," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Layton Lamsam & Brett Gu & Mingli Liang & George Sun & Kamren J. Khan & Kevin N. Sheth & Lawrence J. Hirsch & Christopher Pittenger & Alfred P. Kaye & John H. Krystal & Eyiyemisi C. Damisah, 2024. "The human claustrum tracks slow waves during sleep," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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