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Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis

Author

Listed:
  • Yuying Huang

    (University of Chinese Academy of Sciences)

  • Lin Zhu

    (University of Chinese Academy of Sciences)

  • Shipeng Cheng

    (University of Chinese Academy of Sciences)

  • Ranran Dai

    (Shanghai Jiao Tong University School of Medicine)

  • Chunrong Huang

    (Shanghai Jiao Tong University School of Medicine)

  • Yanyan Song

    (Shanghai Jiao Tong University School of Medicine)

  • Bo Peng

    (Shanghai Jiao Tong University School of Medicine)

  • Xuezhen Li

    (University of Chinese Academy of Sciences)

  • Jing Wen

    (University of Chinese Academy of Sciences)

  • Yi Gong

    (Huashan Hospital Affiliated to Fudan University)

  • Yunqian Hu

    (Tongji University)

  • Ling Qian

    (Fudan University)

  • Linyun Zhu

    (Shanghai Putuo District Central Hospital)

  • Fengying Zhang

    (Shanghai Putuo District People’s Hospital)

  • Li Yu

    (Tongji University)

  • Chunyan Yi

    (University of Chinese Academy of Sciences)

  • Wangpeng Gu

    (University of Chinese Academy of Sciences)

  • Zhiyang Ling

    (University of Chinese Academy of Sciences)

  • Liyan Ma

    (University of Chinese Academy of Sciences)

  • Wei Tang

    (Shanghai Jiao Tong University School of Medicine)

  • Li Peng

    (Shanghai Meteorological Service)

  • Guochao Shi

    (Shanghai Jiao Tong University School of Medicine)

  • Yaguang Zhang

    (University of Chinese Academy of Sciences
    The First Affiliated Hospital of Xi’an JiaoTong University, Xi’an JiaoTong University)

  • Bing Sun

    (University of Chinese Academy of Sciences)

Abstract

The immunomodulatory effects of ultraviolet B (UVB) radiation in human diseases have been described. Whether type 2 lung inflammation is directly affected by solar ultraviolet (UV) radiation is not fully understood. Here, we show a possible negative correlation between solar UVB radiation and asthmatic inflammation in humans and mice. UVB exposure to the eyes induces hypothalamus-pituitary activation and α-melanocyte-stimulating hormone (α-MSH) accumulation in the serum to suppress allergic airway inflammation by targeting group 2 innate lymphoid cells (ILC2) through the MC5R receptor in mice. The α-MSH/MC5R interaction limits ILC2 function through attenuation of JAK/STAT and NF-κB signaling. Consistently, we observe that the plasma α-MSH concentration is negatively correlated with the number and function of ILC2s in the peripheral blood mononuclear cells (PBMC) of patients with asthma. We provide insights into how solar UVB radiation-driven neuroendocrine α-MSH restricts ILC2-mediated lung inflammation and offer a possible strategy for controlling allergic diseases.

Suggested Citation

  • Yuying Huang & Lin Zhu & Shipeng Cheng & Ranran Dai & Chunrong Huang & Yanyan Song & Bo Peng & Xuezhen Li & Jing Wen & Yi Gong & Yunqian Hu & Ling Qian & Linyun Zhu & Fengying Zhang & Li Yu & Chunyan , 2023. "Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41319-1
    DOI: 10.1038/s41467-023-41319-1
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