IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-41319-1.html
   My bibliography  Save this article

Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis

Author

Listed:
  • Yuying Huang

    (University of Chinese Academy of Sciences)

  • Lin Zhu

    (University of Chinese Academy of Sciences)

  • Shipeng Cheng

    (University of Chinese Academy of Sciences)

  • Ranran Dai

    (Shanghai Jiao Tong University School of Medicine)

  • Chunrong Huang

    (Shanghai Jiao Tong University School of Medicine)

  • Yanyan Song

    (Shanghai Jiao Tong University School of Medicine)

  • Bo Peng

    (Shanghai Jiao Tong University School of Medicine)

  • Xuezhen Li

    (University of Chinese Academy of Sciences)

  • Jing Wen

    (University of Chinese Academy of Sciences)

  • Yi Gong

    (Huashan Hospital Affiliated to Fudan University)

  • Yunqian Hu

    (Tongji University)

  • Ling Qian

    (Fudan University)

  • Linyun Zhu

    (Shanghai Putuo District Central Hospital)

  • Fengying Zhang

    (Shanghai Putuo District People’s Hospital)

  • Li Yu

    (Tongji University)

  • Chunyan Yi

    (University of Chinese Academy of Sciences)

  • Wangpeng Gu

    (University of Chinese Academy of Sciences)

  • Zhiyang Ling

    (University of Chinese Academy of Sciences)

  • Liyan Ma

    (University of Chinese Academy of Sciences)

  • Wei Tang

    (Shanghai Jiao Tong University School of Medicine)

  • Li Peng

    (Shanghai Meteorological Service)

  • Guochao Shi

    (Shanghai Jiao Tong University School of Medicine)

  • Yaguang Zhang

    (University of Chinese Academy of Sciences
    The First Affiliated Hospital of Xi’an JiaoTong University, Xi’an JiaoTong University)

  • Bing Sun

    (University of Chinese Academy of Sciences)

Abstract

The immunomodulatory effects of ultraviolet B (UVB) radiation in human diseases have been described. Whether type 2 lung inflammation is directly affected by solar ultraviolet (UV) radiation is not fully understood. Here, we show a possible negative correlation between solar UVB radiation and asthmatic inflammation in humans and mice. UVB exposure to the eyes induces hypothalamus-pituitary activation and α-melanocyte-stimulating hormone (α-MSH) accumulation in the serum to suppress allergic airway inflammation by targeting group 2 innate lymphoid cells (ILC2) through the MC5R receptor in mice. The α-MSH/MC5R interaction limits ILC2 function through attenuation of JAK/STAT and NF-κB signaling. Consistently, we observe that the plasma α-MSH concentration is negatively correlated with the number and function of ILC2s in the peripheral blood mononuclear cells (PBMC) of patients with asthma. We provide insights into how solar UVB radiation-driven neuroendocrine α-MSH restricts ILC2-mediated lung inflammation and offer a possible strategy for controlling allergic diseases.

Suggested Citation

  • Yuying Huang & Lin Zhu & Shipeng Cheng & Ranran Dai & Chunrong Huang & Yanyan Song & Bo Peng & Xuezhen Li & Jing Wen & Yi Gong & Yunqian Hu & Ling Qian & Linyun Zhu & Fengying Zhang & Li Yu & Chunyan , 2023. "Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41319-1
    DOI: 10.1038/s41467-023-41319-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-41319-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-41319-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Daniel R. Neill & See Heng Wong & Agustin Bellosi & Robin J. Flynn & Maria Daly & Theresa K. A. Langford & Christine Bucks & Colleen M. Kane & Padraic G. Fallon & Richard Pannell & Helen E. Jolin & An, 2010. "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity," Nature, Nature, vol. 464(7293), pages 1367-1370, April.
    2. Vânia Cardoso & Julie Chesné & Hélder Ribeiro & Bethania García-Cassani & Tânia Carvalho & Tiffany Bouchery & Kathleen Shah & Nuno L. Barbosa-Morais & Nicola Harris & Henrique Veiga-Fernandes, 2017. "Neuronal regulation of type 2 innate lymphoid cells via neuromedin U," Nature, Nature, vol. 549(7671), pages 277-281, September.
    3. David Artis & Hergen Spits, 2015. "The biology of innate lymphoid cells," Nature, Nature, vol. 517(7534), pages 293-301, January.
    4. Kazuyo Moro & Taketo Yamada & Masanobu Tanabe & Tsutomu Takeuchi & Tomokatsu Ikawa & Hiroshi Kawamoto & Jun-ichi Furusawa & Masashi Ohtani & Hideki Fujii & Shigeo Koyasu, 2010. "Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells," Nature, Nature, vol. 463(7280), pages 540-544, January.
    5. Hiroki Kabata & Kazuyo Moro & Koichi Fukunaga & Yusuke Suzuki & Jun Miyata & Katsunori Masaki & Tomoko Betsuyaku & Shigeo Koyasu & Koichiro Asano, 2013. "Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Carys A. Croft & Anna Thaller & Solenne Marie & Jean-Marc Doisne & Laura Surace & Rui Yang & Anne Puel & Jacinta Bustamante & Jean-Laurent Casanova & James P. Santo, 2022. "Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Jana H. Badrani & Allyssa N. Strohm & Lee Lacasa & Blake Civello & Kellen Cavagnero & Yung-An Haung & Michael Amadeo & Luay H. Naji & Sean J. Lund & Anthea Leng & Hyojoung Kim & Rachel E. Baum & Nasee, 2022. "RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Christophe M. Capelle & Séverine Ciré & Fanny Hedin & Maxime Hansen & Lukas Pavelka & Kamil Grzyb & Dimitrios Kyriakis & Oliver Hunewald & Maria Konstantinou & Dominique Revets & Vera Tslaf & Tainá M., 2023. "Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Bertha Estrella & Elena N. Naumova & Magda Cepeda & Trudy Voortman & Peter D. Katsikis & Hemmo A. Drexhage, 2019. "Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies," IJERPH, MDPI, vol. 16(13), pages 1-15, July.
    5. Natsuko Otaki & Yasutaka Motomura & Tommy Terooatea & S. Thomas Kelly & Miho Mochizuki & Natsuki Takeno & Shigeo Koyasu & Miu Tamamitsu & Fuminori Sugihara & Junichi Kikuta & Hideya Kitamura & Yoshiki, 2023. "Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    6. Alberto Díez-Sánchez & Håvard T. Lindholm & Pia M. Vornewald & Jenny Ostrop & Rouan Yao & Andrew B. Single & Anne Marstad & Naveen Parmar & Tovah N. Shaw & Mara Martín-Alonso & Menno J. Oudhoff, 2024. "LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    7. Valeria Calcaterra & Matteo Vandoni & Virginia Rossi & Clarissa Berardo & Roberta Grazi & Erika Cordaro & Valeria Tranfaglia & Vittoria Carnevale Pellino & Cristina Cereda & Gianvincenzo Zuccotti, 2022. "Use of Physical Activity and Exercise to Reduce Inflammation in Children and Adolescents with Obesity," IJERPH, MDPI, vol. 19(11), pages 1-20, June.
    8. Vaishnavi Nimbalkar & Manish Kamble & Jagdish Baheti, 2020. "In-Vitro Assay to Investigate the Anti-Inflammatory Activity of Hydroalcoholic Leaves Extract of Acacia Auriculiformis A.Cunn. Ex Benth," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 7(4), pages 07-09, April.
    9. Hung-Wei Cheng & Urs Mörbe & Mechthild Lütge & Céline Engetschwiler & Lucas Onder & Mario Novkovic & Cristina Gil-Cruz & Christian Perez-Shibayama & Thomas Hehlgans & Elke Scandella & Burkhard Ludewig, 2022. "Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    10. Min Zhao & Fei Shao & Dou Yu & Jiaqi Zhang & Zhen Liu & Jiangwen Ma & Pengyan Xia & Shuo Wang, 2022. "Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    11. Nian Liu & Jiacheng He & Dongdong Fan & Yang Gu & Jianyi Wang & Huimu Li & Xiaoxiao Zhu & Ying Du & Yong Tian & Benyu Liu & Zusen Fan, 2022. "Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41319-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.