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Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

Author

Listed:
  • Kazuyo Moro

    (Department of Microbiology and Immunology,
    Japan Science and Technology Agency (JST), CREST, Chiyoda-ku, Tokyo 102-0075, Japan)

  • Taketo Yamada

    (Department of Pathology,)

  • Masanobu Tanabe

    (Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan)

  • Tsutomu Takeuchi

    (Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan)

  • Tomokatsu Ikawa

    (Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan)

  • Hiroshi Kawamoto

    (Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan)

  • Jun-ichi Furusawa

    (Department of Microbiology and Immunology,)

  • Masashi Ohtani

    (Department of Microbiology and Immunology,
    Institute of Biomedical Science, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan)

  • Hideki Fujii

    (Department of Microbiology and Immunology,)

  • Shigeo Koyasu

    (Department of Microbiology and Immunology,
    Research Center for Science Systems, Japan Society for the Promotion of Science (JSPS), Chiyoda-ku, Tokyo 102-8472, Japan)

Abstract

Natural helper cells Natural killer cells are innate immune cells that react to viral and bacterial infections by producing various cytokines. Moro et al. report the presence in the mesenteric lymphoid nodules of a previously unrecognized subset of innate lymphoid cells which produce TH2 cytokines and act as helpers for B1 cells. These natural helper cells may play a role in defence against helminths through the activation of mucus production by goblet cells.

Suggested Citation

  • Kazuyo Moro & Taketo Yamada & Masanobu Tanabe & Tsutomu Takeuchi & Tomokatsu Ikawa & Hiroshi Kawamoto & Jun-ichi Furusawa & Masashi Ohtani & Hideki Fujii & Shigeo Koyasu, 2010. "Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells," Nature, Nature, vol. 463(7280), pages 540-544, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08636
    DOI: 10.1038/nature08636
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    1. Yuying Huang & Lin Zhu & Shipeng Cheng & Ranran Dai & Chunrong Huang & Yanyan Song & Bo Peng & Xuezhen Li & Jing Wen & Yi Gong & Yunqian Hu & Ling Qian & Linyun Zhu & Fengying Zhang & Li Yu & Chunyan , 2023. "Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Valeria Calcaterra & Matteo Vandoni & Virginia Rossi & Clarissa Berardo & Roberta Grazi & Erika Cordaro & Valeria Tranfaglia & Vittoria Carnevale Pellino & Cristina Cereda & Gianvincenzo Zuccotti, 2022. "Use of Physical Activity and Exercise to Reduce Inflammation in Children and Adolescents with Obesity," IJERPH, MDPI, vol. 19(11), pages 1-20, June.
    3. Jana H. Badrani & Allyssa N. Strohm & Lee Lacasa & Blake Civello & Kellen Cavagnero & Yung-An Haung & Michael Amadeo & Luay H. Naji & Sean J. Lund & Anthea Leng & Hyojoung Kim & Rachel E. Baum & Nasee, 2022. "RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Kaifan Bao & Xiaoqun Gu & Yajun Song & Yijing Zhou & Yanyan Chen & Xi Yu & Weiyuan Yuan & Liyun Shi & Jie Zheng & Min Hong, 2024. "TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Carys A. Croft & Anna Thaller & Solenne Marie & Jean-Marc Doisne & Laura Surace & Rui Yang & Anne Puel & Jacinta Bustamante & Jean-Laurent Casanova & James P. Santo, 2022. "Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Christophe M. Capelle & Séverine Ciré & Fanny Hedin & Maxime Hansen & Lukas Pavelka & Kamil Grzyb & Dimitrios Kyriakis & Oliver Hunewald & Maria Konstantinou & Dominique Revets & Vera Tslaf & Tainá M., 2023. "Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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