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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

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  • Daniel R. Neill

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • See Heng Wong

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Agustin Bellosi

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Robin J. Flynn

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Maria Daly

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Theresa K. A. Langford

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Christine Bucks

    (Immunology Discovery Research, Centocor R&D Inc., 145 King of Prussia Road, Radnor, Pennsylvania 19087, USA)

  • Colleen M. Kane

    (Immunology Discovery Research, Centocor R&D Inc., 145 King of Prussia Road, Radnor, Pennsylvania 19087, USA)

  • Padraic G. Fallon

    (Institute of Molecular Medicine, Trinity College Dublin)

  • Richard Pannell

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Helen E. Jolin

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Andrew N. J. McKenzie

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

Abstract

Innate immunity: two lines of defence Type-2 immunity, the ancient defence mechanism that provides protection against gastrointestinal helminth infections, involves the recruitment of T helper (TH) cells that produce immune mediators or cytokines to coordinate an immune response involving IgE antibody production, the recruitment of eosinophils and goblet cell hyperplasia. Two groups reporting in this issue have characterized innate type 2 effector leukocyte populations that promote TH2 cytokine responses. Saenz et al. describe multipotent progenitor type-2 (MPPtype2) cells that accumulate in response to the cytokine IL-25 (interleukin-25) and give rise to macrophage or granulocyte lineages promoting TH2 differentiation. Neill et al. describe 'nuocytes', induced by IL25 and IL33, which are the predominant early source of IL13 during a helminth infection. In News & Views, Gérard Eberl discusses how these two papers — and a third in Nature Reviews Immunology ( http://go.nature.com/sJ9D77 ) — influence current thinking on the role of innate immunity.

Suggested Citation

  • Daniel R. Neill & See Heng Wong & Agustin Bellosi & Robin J. Flynn & Maria Daly & Theresa K. A. Langford & Christine Bucks & Colleen M. Kane & Padraic G. Fallon & Richard Pannell & Helen E. Jolin & An, 2010. "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity," Nature, Nature, vol. 464(7293), pages 1367-1370, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7293:d:10.1038_nature08900
    DOI: 10.1038/nature08900
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    Cited by:

    1. Yuying Huang & Lin Zhu & Shipeng Cheng & Ranran Dai & Chunrong Huang & Yanyan Song & Bo Peng & Xuezhen Li & Jing Wen & Yi Gong & Yunqian Hu & Ling Qian & Linyun Zhu & Fengying Zhang & Li Yu & Chunyan , 2023. "Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Carys A. Croft & Anna Thaller & Solenne Marie & Jean-Marc Doisne & Laura Surace & Rui Yang & Anne Puel & Jacinta Bustamante & Jean-Laurent Casanova & James P. Santo, 2022. "Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Alberto Díez-Sánchez & Håvard T. Lindholm & Pia M. Vornewald & Jenny Ostrop & Rouan Yao & Andrew B. Single & Anne Marstad & Naveen Parmar & Tovah N. Shaw & Mara Martín-Alonso & Menno J. Oudhoff, 2024. "LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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