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Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis

Author

Listed:
  • Min Zhao

    (Chinese Academy of Sciences)

  • Fei Shao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Dou Yu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jiaqi Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhen Liu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jiangwen Ma

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Pengyan Xia

    (Peking University)

  • Shuo Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Innate lymphoid cells (ILC) are abundant in mucosal tissues. They serve critical functions in anti-pathogen response and tissue homeostasis. However, the heterogenous composition of ILCs in mucosal sites and their various maturation trajectories are less well known. In this study, we characterize ILC types and functions from both the lung and the small intestine, and identify their tissue-specific markers. We find that ILC2s residing in the lung express CCR2, whereas intestinal ILC2s express CCR4. Through the use of CCR2 and CCR4 reporter mice, we show that ILC2s undergo translocation via the lung-gut axis upon IL-33 treatment. This trajectory of ILC2s is also observed at the postnatal stage. Allergen-induced activation of lung ILC2s affects the homeostasis of gut ILC2s. Together, our findings implicate that ILCs display tissue-specific features in both the lung and gut, and ILC2s mature along the lung-gut axis in particular homeostatic and inflammatory conditions.

Suggested Citation

  • Min Zhao & Fei Shao & Dou Yu & Jiaqi Zhang & Zhen Liu & Jiangwen Ma & Pengyan Xia & Shuo Wang, 2022. "Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35347-6
    DOI: 10.1038/s41467-022-35347-6
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    References listed on IDEAS

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    1. François Gerbe & Emmanuelle Sidot & Danielle J. Smyth & Makoto Ohmoto & Ichiro Matsumoto & Valérie Dardalhon & Pierre Cesses & Laure Garnier & Marie Pouzolles & Bénédicte Brulin & Marco Bruschi & Yvon, 2016. "Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites," Nature, Nature, vol. 529(7585), pages 226-230, January.
    2. David Artis & Hergen Spits, 2015. "The biology of innate lymphoid cells," Nature, Nature, vol. 517(7534), pages 293-301, January.
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    Cited by:

    1. Xusheng Zhang & Xintong Gao & Zhen Liu & Fei Shao & Dou Yu & Min Zhao & Xiwen Qin & Shuo Wang, 2024. "Microbiota regulates the TET1-mediated DNA hydroxymethylation program in innate lymphoid cell differentiation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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