IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-35347-6.html
   My bibliography  Save this article

Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis

Author

Listed:
  • Min Zhao

    (Chinese Academy of Sciences)

  • Fei Shao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Dou Yu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jiaqi Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhen Liu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jiangwen Ma

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Pengyan Xia

    (Peking University)

  • Shuo Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Innate lymphoid cells (ILC) are abundant in mucosal tissues. They serve critical functions in anti-pathogen response and tissue homeostasis. However, the heterogenous composition of ILCs in mucosal sites and their various maturation trajectories are less well known. In this study, we characterize ILC types and functions from both the lung and the small intestine, and identify their tissue-specific markers. We find that ILC2s residing in the lung express CCR2, whereas intestinal ILC2s express CCR4. Through the use of CCR2 and CCR4 reporter mice, we show that ILC2s undergo translocation via the lung-gut axis upon IL-33 treatment. This trajectory of ILC2s is also observed at the postnatal stage. Allergen-induced activation of lung ILC2s affects the homeostasis of gut ILC2s. Together, our findings implicate that ILCs display tissue-specific features in both the lung and gut, and ILC2s mature along the lung-gut axis in particular homeostatic and inflammatory conditions.

Suggested Citation

  • Min Zhao & Fei Shao & Dou Yu & Jiaqi Zhang & Zhen Liu & Jiangwen Ma & Pengyan Xia & Shuo Wang, 2022. "Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35347-6
    DOI: 10.1038/s41467-022-35347-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35347-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35347-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. François Gerbe & Emmanuelle Sidot & Danielle J. Smyth & Makoto Ohmoto & Ichiro Matsumoto & Valérie Dardalhon & Pierre Cesses & Laure Garnier & Marie Pouzolles & Bénédicte Brulin & Marco Bruschi & Yvon, 2016. "Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites," Nature, Nature, vol. 529(7585), pages 226-230, January.
    2. David Artis & Hergen Spits, 2015. "The biology of innate lymphoid cells," Nature, Nature, vol. 517(7534), pages 293-301, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xiwen Xiong & Chenyan Yang & Wei-Qi He & Jiahui Yu & Yue Xin & Xinge Zhang & Rong Huang & Honghui Ma & Shaofang Xu & Zun Li & Jie Ma & Lin Xu & Qunyi Wang & Kaiqun Ren & Xiaoli S. Wu & Christopher R. , 2022. "Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Yuying Huang & Lin Zhu & Shipeng Cheng & Ranran Dai & Chunrong Huang & Yanyan Song & Bo Peng & Xuezhen Li & Jing Wen & Yi Gong & Yunqian Hu & Ling Qian & Linyun Zhu & Fengying Zhang & Li Yu & Chunyan , 2023. "Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Ryan N. O’Keefe & Annalisa L. E. Carli & David Baloyan & David Chisanga & Wei Shi & Shoukat Afshar-Sterle & Moritz F. Eissmann & Ashleigh R. Poh & Bhupinder Pal & Cyril Seillet & Richard M. Locksley &, 2023. "A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Bertha Estrella & Elena N. Naumova & Magda Cepeda & Trudy Voortman & Peter D. Katsikis & Hemmo A. Drexhage, 2019. "Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies," IJERPH, MDPI, vol. 16(13), pages 1-15, July.
    5. Ihab Ansari & Llorenç Solé-Boldo & Meshi Ridnik & Julian Gutekunst & Oliver Gilliam & Maria Korshko & Timur Liwinski & Birgit Jickeli & Noa Weinberg-Corem & Michal Shoshkes-Carmel & Eli Pikarsky & Era, 2023. "TET2 and TET3 loss disrupts small intestine differentiation and homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Jana H. Badrani & Allyssa N. Strohm & Lee Lacasa & Blake Civello & Kellen Cavagnero & Yung-An Haung & Michael Amadeo & Luay H. Naji & Sean J. Lund & Anthea Leng & Hyojoung Kim & Rachel E. Baum & Nasee, 2022. "RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Vaishnavi Nimbalkar & Manish Kamble & Jagdish Baheti, 2020. "In-Vitro Assay to Investigate the Anti-Inflammatory Activity of Hydroalcoholic Leaves Extract of Acacia Auriculiformis A.Cunn. Ex Benth," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 7(4), pages 07-09, April.
    8. Hung-Wei Cheng & Urs Mörbe & Mechthild Lütge & Céline Engetschwiler & Lucas Onder & Mario Novkovic & Cristina Gil-Cruz & Christian Perez-Shibayama & Thomas Hehlgans & Elke Scandella & Burkhard Ludewig, 2022. "Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    9. Nian Liu & Jiacheng He & Dongdong Fan & Yang Gu & Jianyi Wang & Huimu Li & Xiaoxiao Zhu & Ying Du & Yong Tian & Benyu Liu & Zusen Fan, 2022. "Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35347-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.