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Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies

Author

Listed:
  • Bertha Estrella

    (Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito 170521, Ecuador)

  • Elena N. Naumova

    (Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA)

  • Magda Cepeda

    (Department of Epidemiology, Erasmus Medical Center, 3015GD Rotterdam, The Netherlands)

  • Trudy Voortman

    (Department of Epidemiology, Erasmus Medical Center, 3015GD Rotterdam, The Netherlands)

  • Peter D. Katsikis

    (Department of Immunology, Erasmus Medical Center, 3015GD Rotterdam, The Netherlands)

  • Hemmo A. Drexhage

    (Department of Immunology, Erasmus Medical Center, 3015GD Rotterdam, The Netherlands)

Abstract

Outdoor air pollution is associated with respiratory infections and allergies, yet the role of innate lymphoid cells (ILCs) in pathogen containment and airway hyperresponsiveness relevant to effects of air pollutants on ILCs is poorly understood. We conducted a systematic review to evaluate the available evidence on the effect of outdoor air pollutants on the lung type 1 (ILC1) and type 2 ILCs (ILC2) subsets. We searched five electronic databases (up to Dec 2018) for studies on the effect of carbon monoxide (CO), sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), diesel exhaust particles (DEP), ozone (O 3 ), and particulate matter (PM) on respiratory ILCs. Of 2209 identified citations, 22 full-text papers were assessed for eligibility, and 12 articles describing experimental studies performed in murine strains (9) and on human blood cells (3) were finally selected. Overall, these studies showed that exposure to PM, DEP, and high doses of O 3 resulted in a reduction of interferon gamma (IFN-γ) production and cytotoxicity of ILC1. These pollutants and carbon nanotubes stimulate lung ILC2s, produce high levels of interleukin (IL)-5 and IL-13, and induce airway hyperresponsiveness. These findings highlight potential mechanisms by which human ILCs react to air pollution that increase the susceptibility to infections and allergies.

Suggested Citation

  • Bertha Estrella & Elena N. Naumova & Magda Cepeda & Trudy Voortman & Peter D. Katsikis & Hemmo A. Drexhage, 2019. "Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies," IJERPH, MDPI, vol. 16(13), pages 1-15, July.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:13:p:2347-:d:245161
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    References listed on IDEAS

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    1. Carol Kilkenny & William J Browne & Innes C Cuthill & Michael Emerson & Douglas G Altman, 2010. "Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research," PLOS Biology, Public Library of Science, vol. 8(6), pages 1-5, June.
    2. David Artis & Hergen Spits, 2015. "The biology of innate lymphoid cells," Nature, Nature, vol. 517(7534), pages 293-301, January.
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