Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-023-38439-z
Download full text from publisher
References listed on IDEAS
- Yue Li & Norihiro Imai & Hayley T. Nicholls & Blaine R. Roberts & Samaksh Goyal & Tibor I. Krisko & Lay-Hong Ang & Matthew C. Tillman & Anne M. Roberts & Mahnoor Baqai & Eric A. Ortlund & David E. Coh, 2021. "Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
- Silvana Konermann & Mark D. Brigham & Alexandro E. Trevino & Julia Joung & Omar O. Abudayyeh & Clea Barcena & Patrick D. Hsu & Naomi Habib & Jonathan S. Gootenberg & Hiroshi Nishimasu & Osamu Nureki &, 2015. "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex," Nature, Nature, vol. 517(7536), pages 583-588, January.
- Matthew D. Schultz & Yupeng He & John W. Whitaker & Manoj Hariharan & Eran A. Mukamel & Danny Leung & Nisha Rajagopal & Joseph R. Nery & Mark A. Urich & Huaming Chen & Shin Lin & Yiing Lin & Inkyung J, 2015. "Human body epigenome maps reveal noncanonical DNA methylation variation," Nature, Nature, vol. 523(7559), pages 212-216, July.
- Daniel Trejo Banos & Daniel L. McCartney & Marion Patxot & Lucas Anchieri & Thomas Battram & Colette Christiansen & Ricardo Costeira & Rosie M. Walker & Stewart W. Morris & Archie Campbell & Qian Zhan, 2020. "Bayesian reassessment of the epigenetic architecture of complex traits," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
- Dirk S. Paul & Andrew E. Teschendorff & Mary A.N. Dang & Robert Lowe & Mohammed I. Hawa & Simone Ecker & Huriya Beyan & Stephanie Cunningham & Alexandra R. Fouts & Anita Ramelius & Frances Burden & Sa, 2016. "Increased DNA methylation variability in type 1 diabetes across three immune effector cell types," Nature Communications, Nature, vol. 7(1), pages 1-11, December.
- David Z. Pan & Kristina M. Garske & Marcus Alvarez & Yash V. Bhagat & James Boocock & Elina Nikkola & Zong Miao & Chelsea K. Raulerson & Rita M. Cantor & Mete Civelek & Craig A. Glastonbury & Kerrin S, 2018. "Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS," Nature Communications, Nature, vol. 9(1), pages 1-1, December.
- Simone Wahl & Alexander Drong & Benjamin Lehne & Marie Loh & William R. Scott & Sonja Kunze & Pei-Chien Tsai & Janina S. Ried & Weihua Zhang & Youwen Yang & Sili Tan & Giovanni Fiorito & Lude Franke &, 2017. "Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity," Nature, Nature, vol. 541(7635), pages 81-86, January.
- Gibran Hemani & Kate Tilling & George Davey Smith, 2017. "Orienting the causal relationship between imprecisely measured traits using GWAS summary data," PLOS Genetics, Public Library of Science, vol. 13(11), pages 1-22, November.
- Kailong Li & Yuxuan Liu & Hui Cao & Yuannyu Zhang & Zhimin Gu & Xin Liu & Andy Yu & Pranita Kaphle & Kathryn E. Dickerson & Min Ni & Jian Xu, 2020. "Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
- Kirsty L. Spalding & Erik Arner & Pål O. Westermark & Samuel Bernard & Bruce A. Buchholz & Olaf Bergmann & Lennart Blomqvist & Johan Hoffstedt & Erik Näslund & Tom Britton & Hernan Concha & Moustapha , 2008. "Dynamics of fat cell turnover in humans," Nature, Nature, vol. 453(7196), pages 783-787, June.
- Angli Xue & Yang Wu & Zhihong Zhu & Futao Zhang & Kathryn E. Kemper & Zhili Zheng & Loic Yengo & Luke R. Lloyd-Jones & Julia Sidorenko & Yeda Wu & Allan F. McRae & Peter M. Visscher & Jian Zeng & Jian, 2018. "Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
- Peipei Li & Lee Marshall & Gabriel Oh & Jennifer L. Jakubowski & Daniel Groot & Yu He & Ting Wang & Arturas Petronis & Viviane Labrie, 2019. "Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
- Sneha Damal Villivalam & Dongjoo You & Jinse Kim & Hee Woong Lim & Han Xiao & Pete-James H. Zushin & Yasuo Oguri & Pouya Amin & Sona Kang, 2020. "TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
- Karl Bacos & Linn Gillberg & Petr Volkov & Anders H Olsson & Torben Hansen & Oluf Pedersen & Anette Prior Gjesing & Hans Eiberg & Tiinamaija Tuomi & Peter Almgren & Leif Groop & Lena Eliasson & Allan , 2016. "Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes," Nature Communications, Nature, vol. 7(1), pages 1-13, April.
- Shian-Huey Chiang & Christian A. Baumann & Makoto Kanzaki & Debbie C. Thurmond & Robert T. Watson & Cheryl L. Neudauer & Ian G. Macara & Jeffrey E. Pessin & Alan R. Saltiel, 2001. "Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10," Nature, Nature, vol. 410(6831), pages 944-948, April.
- Daniel Trejo Banos & Daniel L. McCartney & Marion Patxot & Lucas Anchieri & Thomas Battram & Colette Christiansen & Ricardo Costeira & Rosie M. Walker & Stewart W. Morris & Archie Campbell & Qian Zhan, 2020. "Author Correction: Bayesian reassessment of the epigenetic architecture of complex traits," Nature Communications, Nature, vol. 11(1), pages 1-1, December.
- Anshul Kundaje & Wouter Meuleman & Jason Ernst & Misha Bilenky & Angela Yen & Alireza Heravi-Moussavi & Pouya Kheradpour & Zhizhuo Zhang & Jianrong Wang & Michael J. Ziller & Viren Amin & John W. Whit, 2015. "Integrative analysis of 111 reference human epigenomes," Nature, Nature, vol. 518(7539), pages 317-330, February.
- Xiaoli Hou & Yongzhao Zhang & Wei Li & Alexander J. Hu & Chi Luo & Wenhui Zhou & Jamie K. Hu & Stefano G. Daniele & Jinfeng Wang & Jinghao Sheng & Yongsheng Fan & Andrew S. Greenberg & Stephen R. Farm, 2018. "CDK6 inhibits white to beige fat transition by suppressing RUNX1," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
- Sarah E. Graham & Shoa L. Clarke & Kuan-Han H. Wu & Stavroula Kanoni & Greg J. M. Zajac & Shweta Ramdas & Ida Surakka & Ioanna Ntalla & Sailaja Vedantam & Thomas W. Winkler & Adam E. Locke & Eirini Ma, 2021. "The power of genetic diversity in genome-wide association studies of lipids," Nature, Nature, vol. 600(7890), pages 675-679, December.
- David Z. Pan & Kristina M. Garske & Marcus Alvarez & Yash V. Bhagat & James Boocock & Elina Nikkola & Zong Miao & Chelsea K. Raulerson & Rita M. Cantor & Mete Civelek & Craig A. Glastonbury & Kerrin S, 2018. "Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Thomas Battram & Tom R. Gaunt & Caroline L. Relton & Nicholas J. Timpson & Gibran Hemani, 2022. "A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Danielle Rasooly & Gina M. Peloso & Alexandre C. Pereira & Hesam Dashti & Claudia Giambartolomei & Eleanor Wheeler & Nay Aung & Brian R. Ferolito & Maik Pietzner & Eric H. Farber-Eger & Quinn Stanton , 2023. "Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Adrienne Tin & Pascal Schlosser & Pamela R. Matias-Garcia & Chris H. L. Thio & Roby Joehanes & Hongbo Liu & Zhi Yu & Antoine Weihs & Anselm Hoppmann & Franziska Grundner-Culemann & Josine L. Min & Vic, 2021. "Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
- Matthias Wielscher & Pooja R. Mandaviya & Brigitte Kuehnel & Roby Joehanes & Rima Mustafa & Oliver Robinson & Yan Zhang & Barbara Bodinier & Esther Walton & Pashupati P. Mishra & Pascal Schlosser & Ro, 2022. "DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
- Long Jin & Danyang Wang & Jiaman Zhang & Pengliang Liu & Yujie Wang & Yu Lin & Can Liu & Ziyin Han & Keren Long & Diyan Li & Yu Jiang & Guisen Li & Yu Zhang & Jingyi Bai & Xiaokai Li & Jing Li & Lu Lu, 2023. "Dynamic chromatin architecture of the porcine adipose tissues with weight gain and loss," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
- Marion Patxot & Daniel Trejo Banos & Athanasios Kousathanas & Etienne J. Orliac & Sven E. Ojavee & Gerhard Moser & Alexander Holloway & Julia Sidorenko & Zoltan Kutalik & Reedik Mägi & Peter M. Vissch, 2021. "Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
- Ankush Auradkar & Annabel Guichard & Saluja Kaduwal & Marketta Sneider & Ethan Bier, 2023. "tgCRISPRi: efficient gene knock-down using truncated gRNAs and catalytically active Cas9," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
- Qiang Zhang & Sai Ma & Zhengzhi Liu & Bohan Zhu & Zirui Zhou & Gaoshan Li & J. Javier Meana & Javier González-Maeso & Chang Lu, 2023. "Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
- Heathcliff Dorado García & Fabian Pusch & Yi Bei & Jennifer Stebut & Glorymar Ibáñez & Kristina Guillan & Koshi Imami & Dennis Gürgen & Jana Rolff & Konstantin Helmsauer & Stephanie Meyer-Liesener & N, 2022. "Therapeutic targeting of ATR in alveolar rhabdomyosarcoma," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
- Michael G. Levin & Noah L. Tsao & Pankhuri Singhal & Chang Liu & Ha My T. Vy & Ishan Paranjpe & Joshua D. Backman & Tiffany R. Bellomo & William P. Bone & Kiran J. Biddinger & Qin Hui & Ozan Dikilitas, 2022. "Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
- Nicole Deflaux & Margaret Sunitha Selvaraj & Henry Robert Condon & Kelsey Mayo & Sara Haidermota & Melissa A. Basford & Chris Lunt & Anthony A. Philippakis & Dan M. Roden & Joshua C. Denny & Anjene Mu, 2023. "Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
- Fasil Tekola-Ayele & Xuehuo Zeng & Suvo Chatterjee & Marion Ouidir & Corina Lesseur & Ke Hao & Jia Chen & Markos Tesfaye & Carmen J. Marsit & Tsegaselassie Workalemahu & Ronald Wapner, 2022. "Placental multi-omics integration identifies candidate functional genes for birthweight," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
- Wendiao Zhang & Ming Zhang & Zhenhong Xu & Hongye Yan & Huimin Wang & Jiamei Jiang & Juan Wan & Beisha Tang & Chunyu Liu & Chao Chen & Qingtuan Meng, 2023. "Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
- Xiangfeng Kong & Hainan Zhang & Guoling Li & Zikang Wang & Xuqiang Kong & Lecong Wang & Mingxing Xue & Weihong Zhang & Yao Wang & Jiajia Lin & Jingxing Zhou & Xiaowen Shen & Yinghui Wei & Na Zhong & W, 2023. "Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
- Jian Wang & Yuxi Teng & Ruihua Zhang & Yifei Wu & Lei Lou & Yusong Zou & Michelle Li & Zhong-Ru Xie & Yajun Yan, 2021. "Engineering a PAM-flexible SpdCas9 variant as a universal gene repressor," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
- Clark, Andrew E. & Etilé, Fabrice, 2011.
"Happy house: Spousal weight and individual well-being,"
Journal of Health Economics, Elsevier, vol. 30(5), pages 1124-1136.
- Andrew E. Clark & Fabrice Etilé, 2010. "Happy House: Spousal Weight and Individual Well-Being," SOEPpapers on Multidisciplinary Panel Data Research 349, DIW Berlin, The German Socio-Economic Panel (SOEP).
- Andrew E. Clark & Fabrice Etilé, 2011. "Happy House: Spousal Weight and Individual Well-Being," PSE-Ecole d'économie de Paris (Postprint) halshs-00654627, HAL.
- Clark, Andrew E. & Etilé, Fabrice, 2010. "Happy House: Spousal Weight and Individual Well-Being," CEPREMAP Working Papers (Docweb) 1001, CEPREMAP.
- Andrew E. Clark & Fabrice Etilé, 2010. "Happy house: Spousal weight and individual well-being," Working Papers halshs-00564836, HAL.
- Andrew E. Clark & Fabrice Etilé, 2010. "Happy house: Spousal weight and individual well-being," PSE Working Papers halshs-00564836, HAL.
- Clark, A. & Etilé, F., 2010. "Happy House: Spousal weight and individual well-being," Health, Econometrics and Data Group (HEDG) Working Papers 10/10, HEDG, c/o Department of Economics, University of York.
- Andrew E. Clark & Fabrice Etilé, 2011. "Happy House: Spousal Weight and Individual Well-Being," Post-Print halshs-00654627, HAL.
- Marina Vabistsevits & George Davey Smith & Tom G. Richardson & Rebecca C. Richmond & Weiva Sieh & Joseph H. Rothstein & Laurel A. Habel & Stacey E. Alexeeff & Bethan Lloyd-Lewis & Eleanor Sanderson, 2024. "Mammographic density mediates the protective effect of early-life body size on breast cancer risk," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Xiaofeng Zhu & Yihe Yang & Noah Lorincz-Comi & Gen Li & Amy R. Bentley & Paul S. de Vries & Michael Brown & Alanna C. Morrison & Charles N. Rotimi & W. James Gauderman & Dabeeru C. Rao & Hugues Aschar, 2024. "An approach to identify gene-environment interactions and reveal new biological insight in complex traits," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
- Injeong Shim & Hiroyuki Kuwahara & NingNing Chen & Mais O. Hashem & Lama AlAbdi & Mohamed Abouelhoda & Hong-Hee Won & Pradeep Natarajan & Patrick T. Ellinor & Amit V. Khera & Xin Gao & Fowzan S. Alkur, 2023. "Clinical utility of polygenic scores for cardiometabolic disease in Arabs," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
- Pingting Ying & Can Chen & Zequn Lu & Shuoni Chen & Ming Zhang & Yimin Cai & Fuwei Zhang & Jinyu Huang & Linyun Fan & Caibo Ning & Yanmin Li & Wenzhuo Wang & Hui Geng & Yizhuo Liu & Wen Tian & Zhiyong, 2023. "Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38439-z. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.