IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v523y2015i7559d10.1038_nature14465.html
   My bibliography  Save this article

Human body epigenome maps reveal noncanonical DNA methylation variation

Author

Listed:
  • Matthew D. Schultz

    (Bioinformatics Program, University of California
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies
    †Present addresses: Human Longevity Inc., La Jolla, California 92121, USA (M.D.S.); Discovery Science, Janssen Pharmaceutical of Johnson & Johnson, La Jolla, California 92121, USA (J.W.W.))

  • Yupeng He

    (Bioinformatics Program, University of California
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies)

  • John W. Whitaker

    (University of California
    †Present addresses: Human Longevity Inc., La Jolla, California 92121, USA (M.D.S.); Discovery Science, Janssen Pharmaceutical of Johnson & Johnson, La Jolla, California 92121, USA (J.W.W.))

  • Manoj Hariharan

    (Genomic Analysis Laboratory, The Salk Institute for Biological Studies)

  • Eran A. Mukamel

    (Computational Neurobiology Laboratory, The Salk Institute for Biological Studies
    University of California)

  • Danny Leung

    (Ludwig Institute for Cancer Research)

  • Nisha Rajagopal

    (Ludwig Institute for Cancer Research)

  • Joseph R. Nery

    (Genomic Analysis Laboratory, The Salk Institute for Biological Studies)

  • Mark A. Urich

    (Genomic Analysis Laboratory, The Salk Institute for Biological Studies)

  • Huaming Chen

    (Genomic Analysis Laboratory, The Salk Institute for Biological Studies)

  • Shin Lin

    (Stanford University)

  • Yiing Lin

    (Washington University School of Medicine)

  • Inkyung Jung

    (Ludwig Institute for Cancer Research)

  • Anthony D. Schmitt

    (Ludwig Institute for Cancer Research)

  • Siddarth Selvaraj

    (Bioinformatics Program, University of California)

  • Bing Ren

    (Ludwig Institute for Cancer Research
    University of California, San Diego School of Medicine, Institute of Genomic Medicine)

  • Terrence J. Sejnowski

    (Computational Neurobiology Laboratory, The Salk Institute for Biological Studies
    University of California at San Diego
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies)

  • Wei Wang

    (University of California
    University of California)

  • Joseph R. Ecker

    (Genomic Analysis Laboratory, The Salk Institute for Biological Studies
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies)

Abstract

As part of the Epigenome Roadmap Project, genome-wide maps of DNA methylation and transcriptomes together with genomic DNA sequencing of 18 different primary human tissue types from 4 individuals are presented; analysis reveals widespread differential methylation of CG sites between tissues, and the presence of non-CG methylation in adult tissues.

Suggested Citation

  • Matthew D. Schultz & Yupeng He & John W. Whitaker & Manoj Hariharan & Eran A. Mukamel & Danny Leung & Nisha Rajagopal & Joseph R. Nery & Mark A. Urich & Huaming Chen & Shin Lin & Yiing Lin & Inkyung J, 2015. "Human body epigenome maps reveal noncanonical DNA methylation variation," Nature, Nature, vol. 523(7559), pages 212-216, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7559:d:10.1038_nature14465
    DOI: 10.1038/nature14465
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14465
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14465?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jamie L. Endicott & Paula A. Nolte & Hui Shen & Peter W. Laird, 2022. "Cell division drives DNA methylation loss in late-replicating domains in primary human cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Qiang Zhang & Sai Ma & Zhengzhi Liu & Bohan Zhu & Zirui Zhou & Gaoshan Li & J. Javier Meana & Javier González-Maeso & Chang Lu, 2023. "Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Victoria L. Sork & Shawn J. Cokus & Sorel T. Fitz-Gibbon & Aleksey V. Zimin & Daniela Puiu & Jesse A. Garcia & Paul F. Gugger & Claudia L. Henriquez & Ying Zhen & Kirk E. Lohmueller & Matteo Pellegrin, 2022. "High-quality genome and methylomes illustrate features underlying evolutionary success of oaks," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Liam McAllan & Damir Baranasic & Sergio Villicaña & Scarlett Brown & Weihua Zhang & Benjamin Lehne & Marco Adamo & Andrew Jenkinson & Mohamed Elkalaawy & Borzoueh Mohammadi & Majid Hashemi & Nadia Fer, 2023. "Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Hagar Taman & Christopher G Fenton & Endre Anderssen & Jon Florholmen & Ruth H Paulssen, 2021. "DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-17, April.
    6. Iryna Ivasyk & Leonora Olivos-Cisneros & Stephany Valdés-Rodríguez & Marie Droual & Hosung Jang & Robert J. Schmitz & Daniel J. C. Kronauer, 2023. "DNMT1 mutant ants develop normally but have disrupted oogenesis," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    7. André Bortolini Silveira & Alexandre Houy & Olivier Ganier & Begüm Özemek & Sandra Vanhuele & Anne Vincent-Salomon & Nathalie Cassoux & Pascale Mariani & Gaelle Pierron & Serge Leyvraz & Damian Rieke , 2024. "Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    8. Yinwen Zhang & Hosung Jang & Rui Xiao & Ioanna Kakoulidou & Robert S. Piecyk & Frank Johannes & Robert J. Schmitz, 2021. "Heterochromatin is a quantitative trait associated with spontaneous epiallele formation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    9. Andrea L Liebl & Jeff S Wesner & Andrew F Russell & Aaron W Schrey, 2021. "Methylation patterns at fledging predict delayed dispersal in a cooperatively breeding bird," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-13, June.
    10. Min-Rui-Xuan Xu & Zhen-Yang Liao & Jordan R. Brock & Kang Du & Guo-Yin Li & Zhi-Qiang Chen & Ying-Hao Wang & Zhong-Nan Gao & Gaurav Agarwal & Kevin H-C Wei & Feng Shao & Shuai Pang & Adrian E. Platts , 2023. "Maternal dominance contributes to subgenome differentiation in allopolyploid fishes," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    11. Johanna Klughammer & Daria Romanovskaia & Amelie Nemc & Annika Posautz & Charlotte A. Seid & Linda C. Schuster & Melissa C. Keinath & Juan Sebastian Lugo Ramos & Lindsay Kosack & Ann Evankow & Dieter , 2023. "Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:523:y:2015:i:7559:d:10.1038_nature14465. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.