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The genetic landscape of basal ganglia and implications for common brain disorders

Author

Listed:
  • Shahram Bahrami

    (University of Oslo
    University of Oslo)

  • Kaja Nordengen

    (University of Oslo
    Oslo University Hospital)

  • Jaroslav Rokicki

    (Oslo University Hospital)

  • Alexey A. Shadrin

    (University of Oslo
    University of Oslo)

  • Zillur Rahman

    (University of Oslo)

  • Olav B. Smeland

    (University of Oslo)

  • Piotr P. Jaholkowski

    (University of Oslo)

  • Nadine Parker

    (University of Oslo)

  • Pravesh Parekh

    (University of Oslo)

  • Kevin S. O’Connell

    (University of Oslo)

  • Torbjørn Elvsåshagen

    (University of Oslo
    Oslo University Hospital
    University of Oslo)

  • Mathias Toft

    (University of Oslo
    Oslo University Hospital)

  • Srdjan Djurovic

    (University of Oslo
    Oslo University Hospital)

  • Anders M. Dale

    (University of California San Diego
    San Diego
    University of California San Diego
    San Diego)

  • Lars T. Westlye

    (University of Oslo
    University of Oslo)

  • Tobias Kaufmann

    (University of Oslo
    University of Tübingen
    German Center for Mental Health (DZPG))

  • Ole A. Andreassen

    (University of Oslo
    University of Oslo
    Oslo University Hospital)

Abstract

The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans. Our multivariate GWAS identified 72 genetic loci associated with basal ganglia volumes with a replication rate of 55.6% at P

Suggested Citation

  • Shahram Bahrami & Kaja Nordengen & Jaroslav Rokicki & Alexey A. Shadrin & Zillur Rahman & Olav B. Smeland & Piotr P. Jaholkowski & Nadine Parker & Pravesh Parekh & Kevin S. O’Connell & Torbjørn Elvsås, 2024. "The genetic landscape of basal ganglia and implications for common brain disorders," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52583-0
    DOI: 10.1038/s41467-024-52583-0
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    References listed on IDEAS

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