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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

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  • Simone Wahl

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
    German Center for Diabetes Research (DZD))

  • Alexander Drong

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Benjamin Lehne

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London)

  • Marie Loh

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
    Institute of Health Sciences, P.O. Box 5000, FI-90014 University of Oulu
    Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5)

  • William R. Scott

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
    National Heart and Lung Institute, Imperial College London)

  • Sonja Kunze

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Pei-Chien Tsai

    (King’s College London)

  • Janina S. Ried

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Weihua Zhang

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
    Ealing Hospital NHS Trust)

  • Youwen Yang

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London)

  • Sili Tan

    (Cancer Science Institute of Singapore, National University of Singapore)

  • Giovanni Fiorito

    (Human Genetics Foundation—Torino
    University of Torino)

  • Lude Franke

    (University of Groningen, University Medical Center Groningen)

  • Simonetta Guarrera

    (Human Genetics Foundation—Torino
    University of Torino)

  • Silva Kasela

    (Estonian Genome Center, University of Tartu, Riia 23b
    Institute of Molecular and Cell Biology, University of Tartu, Riia 23)

  • Jennifer Kriebel

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
    German Center for Diabetes Research (DZD))

  • Rebecca C. Richmond

    (MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol)

  • Marco Adamo

    (UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals)

  • Uzma Afzal

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
    Ealing Hospital NHS Trust)

  • Mika Ala-Korpela

    (Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu
    NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland
    Computational Medicine, School of Social and Community Medicine, University of Bristol and Medical Research Council Integrative Epidemiology Unit, University of Bristol)

  • Benedetta Albetti

    (EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico)

  • Ole Ammerpohl

    (Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel Campus)

  • Jane F. Apperley

    (Centre for Haematology, Faculty of Medicine, Imperial College London, Hammersmith Campus)

  • Marian Beekman

    (Molecular Epidemiology, Leiden University Medical Center)

  • Pier Alberto Bertazzi

    (EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico)

  • S. Lucas Black

    (Section of Infectious Diseases and Immunity, Imperial College London)

  • Christine Blancher

    (High Throughput Genomics—Oxford Genomic Centre, Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Marc-Jan Bonder

    (University of Groningen, University Medical Center Groningen)

  • Mario Brosch

    (University Hospital of the Technical University Dresden)

  • Maren Carstensen-Kirberg

    (German Center for Diabetes Research (DZD)
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf)

  • Anton J. M. de Craen

    (Gerontology and Geriatrics, Leiden University Medical Center)

  • Simon de Lusignan

    (University of Surrey)

  • Abbas Dehghan

    (Erasmus Medical Centre)

  • Mohamed Elkalaawy

    (UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals
    Medical Research Institute, University of Alexandria)

  • Krista Fischer

    (Estonian Genome Center, University of Tartu, Riia 23b)

  • Oscar H. Franco

    (Erasmus Medical Centre)

  • Tom R. Gaunt

    (MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol)

  • Jochen Hampe

    (University Hospital of the Technical University Dresden)

  • Majid Hashemi

    (UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals)

  • Aaron Isaacs

    (Erasmus Medical Centre)

  • Andrew Jenkinson

    (UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals)

  • Sujeet Jha

    (Diabetes and Obesity, Max Healthcare)

  • Norihiro Kato

    (Research Institute, National Center for Global Health and Medicine)

  • Vittorio Krogh

    (Epidemiology and Prevention Unit, Fondazione IRCSS Istituto Nazionale Tumori)

  • Michael Laffan

    (Centre for Haematology, Faculty of Medicine, Imperial College London, Hammersmith Campus)

  • Christa Meisinger

    (Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Thomas Meitinger

    (Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Human Genetics, Technical University Munich
    DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance)

  • Zuan Yu Mok

    (Cancer Science Institute of Singapore, National University of Singapore)

  • Valeria Motta

    (EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico)

  • Hong Kiat Ng

    (Cancer Science Institute of Singapore, National University of Singapore)

  • Zacharoula Nikolakopoulou

    (Vascular Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London)

  • Georgios Nteliopoulos

    (Centre for Haematology, Faculty of Medicine, Imperial College London, Hammersmith Campus)

  • Salvatore Panico

    (Dipartmento Di Medicina Clinica E Chirurgia Federio II University)

  • Natalia Pervjakova

    (Estonian Genome Center, University of Tartu, Riia 23b
    Institute of Molecular and Cell Biology, University of Tartu, Riia 23)

  • Holger Prokisch

    (Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Human Genetics, Technical University Munich)

  • Wolfgang Rathmann

    (Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf)

  • Michael Roden

    (German Center for Diabetes Research (DZD)
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf
    Medical Faculty, Heinrich Heine University Hospital Düsseldorf)

  • Federica Rota

    (EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico)

  • Michelle Ann Rozario

    (Cancer Science Institute of Singapore, National University of Singapore)

  • Johanna K. Sandling

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
    Molecular Medicine and Science for Life Laboratory, Uppsala University)

  • Clemens Schafmayer

    (University Hospital Schleswig-Holstein, Kiel Campus)

  • Katharina Schramm

    (Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Human Genetics, Technical University Munich)

  • Reiner Siebert

    (Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel Campus
    Institute of Human Genetics, University Hospital of Ulm, Albert-Einstein-Allee 11)

  • P. Eline Slagboom

    (Molecular Epidemiology, Leiden University Medical Center)

  • Pasi Soininen

    (Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu
    NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland)

  • Lisette Stolk

    (Erasmus Medical Centre)

  • Konstantin Strauch

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität)

  • E-Shyong Tai

    (Yong Loo Lin School of Medicine, National University of Singapore
    Saw Swee Hock School of Public Health, National University of Singapore
    Duke-National University of Singapore Graduate Medical School)

  • Letizia Tarantini

    (EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico)

  • Barbara Thorand

    (Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
    German Center for Diabetes Research (DZD))

  • Ettje F. Tigchelaar

    (University of Groningen, University Medical Center Groningen)

  • Rosario Tumino

    (Cancer Registry and Histopathology Unit, ‘Civile—M.P. Arezzo’ Hospital)

  • Andre G. Uitterlinden

    (Erasmus Medical Centre)

  • Cornelia van Duijn

    (Erasmus Medical Centre)

  • Joyce B. J. van Meurs

    (Erasmus Medical Centre)

  • Paolo Vineis

    (Human Genetics Foundation—Torino
    Epidemiology and Public Health, Imperial College London)

  • Ananda Rajitha Wickremasinghe

    (Faculty of Medicine, University of Kelaniya)

  • Cisca Wijmenga

    (University of Groningen, University Medical Center Groningen)

  • Tsun-Po Yang

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Wei Yuan

    (King’s College London
    The Institute of Cancer Research)

  • Alexandra Zhernakova

    (University of Groningen, University Medical Center Groningen)

  • Rachel L. Batterham

    (UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals
    Centre for Obesity Research, Rayne Institute, University College London)

  • George Davey Smith

    (MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol)

  • Panos Deloukas

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
    William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University)

  • Bastiaan T. Heijmans

    (Molecular Epidemiology, Leiden University Medical Center)

  • Christian Herder

    (German Center for Diabetes Research (DZD)
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf)

  • Albert Hofman

    (Erasmus Medical Centre)

  • Cecilia M. Lindgren

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Broad Institute of the Massachusetts Institute of Technology and Harvard University)

  • Lili Milani

    (Estonian Genome Center, University of Tartu, Riia 23b)

  • Pim van der Harst

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen
    Durrer Center for Cardiogenetic Research, ICIN—Netherlands Heart Institute)

  • Annette Peters

    (Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
    German Center for Diabetes Research (DZD)
    DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance)

  • Thomas Illig

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
    Hannover Unified Biobank, Hannover Medical School, Feodor-Lynen-Strasse 15
    Institute of Human Genetics, Hannover Medical School, Carl-Neuberg-Strasse 1)

  • Caroline L. Relton

    (MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol)

  • Melanie Waldenberger

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Marjo-Riitta Järvelin

    (MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London
    Biocenter Oulu, P.O. Box 5000, Aapistie 5A, FI-90014 University of Oulu
    Center for Life Course Epidemiology, Faculty of Medicine, P.O. Box 5000, FI-90014 University of Oulu
    Unit of Primary Care, Oulu University Hospital, Kajaanintie 50)

  • Valentina Bollati

    (EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico)

  • Richie Soong

    (Cancer Science Institute of Singapore, National University of Singapore
    National University Hospital)

  • Tim D. Spector

    (King’s College London)

  • James Scott

    (National Heart and Lung Institute, Imperial College London)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford
    Oxford NIHR Biomedical Research Centre, Churchill Hospital)

  • Paul Elliott

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
    Imperial College Healthcare NHS Trust)

  • Jordana T. Bell

    (King’s College London)

  • Giuseppe Matullo

    (Human Genetics Foundation—Torino
    University of Torino)

  • Christian Gieger

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Jaspal S. Kooner

    (National Heart and Lung Institute, Imperial College London
    Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust)

  • Harald Grallert

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
    German Center for Diabetes Research (DZD))

  • John C. Chambers

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
    Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust
    Lee Kong Chian School of Medicine, Nanyang Technological University)

Abstract

A large-scale epigenome-wide association study identifies changes in DNA methylation associated with body mass index in blood and adipose tissue, and correlates DNA methylation sites with high risk of incident type 2 diabetes.

Suggested Citation

  • Simone Wahl & Alexander Drong & Benjamin Lehne & Marie Loh & William R. Scott & Sonja Kunze & Pei-Chien Tsai & Janina S. Ried & Weihua Zhang & Youwen Yang & Sili Tan & Giovanni Fiorito & Lude Franke &, 2017. "Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity," Nature, Nature, vol. 541(7635), pages 81-86, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7635:d:10.1038_nature20784
    DOI: 10.1038/nature20784
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    Cited by:

    1. Anna Ulrich & Yukyee Wu & Harmen Draisma & John Wharton & Emilia M. Swietlik & Inês Cebola & Eleni Vasilaki & Zhanna Balkhiyarova & Marjo-Riitta Jarvelin & Juha Auvinen & Karl-Heinz Herzig & J. Gerry , 2024. "Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Thomas Battram & Tom R. Gaunt & Caroline L. Relton & Nicholas J. Timpson & Gibran Hemani, 2022. "A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Matthias Wielscher & Pooja R. Mandaviya & Brigitte Kuehnel & Roby Joehanes & Rima Mustafa & Oliver Robinson & Yan Zhang & Barbara Bodinier & Esther Walton & Pashupati P. Mishra & Pascal Schlosser & Ro, 2022. "DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Pui Pik Law & Liudmila A. Mikheeva & Francisco Rodriguez-Algarra & Fredrika Asenius & Maria Gregori & Robert A. E. Seaborne & Selin Yildizoglu & James R. C. Miller & Hemanth Tummala & Robin Mesnage & , 2024. "Ribosomal DNA copy number is associated with body mass in humans and other mammals," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Paola Monti & Simona Iodice & Letizia Tarantini & Francesca Sacchi & Luca Ferrari & Massimiliano Ruscica & Massimiliano Buoli & Luisella Vigna & Angela Cecilia Pesatori & Valentina Bollati, 2021. "Effects of PM Exposure on the Methylation of Clock Genes in A Population of Subjects with Overweight or Obesity," IJERPH, MDPI, vol. 18(3), pages 1-14, January.
    6. Liam McAllan & Damir Baranasic & Sergio Villicaña & Scarlett Brown & Weihua Zhang & Benjamin Lehne & Marco Adamo & Andrew Jenkinson & Mohamed Elkalaawy & Borzoueh Mohammadi & Majid Hashemi & Nadia Fer, 2023. "Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    7. Qin Zeng & Jianfeng Song & Xiaoxiao Sun & Dandan Wang & Xiyan Liao & Yujin Ding & Wanyu Hu & Yayi Jiao & Wuqian Mai & Wufuer Aini & Fanqi Wang & Hui Zhou & Limin Xie & Ying Mei & Yuan Tang & Zhiguo Xi, 2024. "A negative feedback loop between TET2 and leptin in adipocyte regulates body weight," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    8. Hannah Lui Park, 2020. "Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention," IJERPH, MDPI, vol. 17(4), pages 1-18, February.
    9. Adrienne Tin & Pascal Schlosser & Pamela R. Matias-Garcia & Chris H. L. Thio & Roby Joehanes & Hongbo Liu & Zhi Yu & Antoine Weihs & Anselm Hoppmann & Franziska Grundner-Culemann & Josine L. Min & Vic, 2021. "Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    10. Wei Zhao & Farah Ammous & Scott Ratliff & Jiaxuan Liu & Miao Yu & Thomas H. Mosley & Sharon L. R. Kardia & Jennifer A. Smith, 2019. "Education and Lifestyle Factors Are Associated with DNA Methylation Clocks in Older African Americans," IJERPH, MDPI, vol. 16(17), pages 1-18, August.
    11. Ayoung Jeong & Medea Imboden & Akram Ghantous & Alexei Novoloaca & Anne-Elie Carsin & Manolis Kogevinas & Christian Schindler & Gianfranco Lovison & Zdenko Herceg & Cyrille Cuenin & Roel Vermeulen & D, 2019. "DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma," IJERPH, MDPI, vol. 16(4), pages 1-15, February.

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