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Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Author

Listed:
  • Adrienne Tin

    (University of Mississippi Medical Center
    Johns Hopkins Bloomberg School of Public Health)

  • Pascal Schlosser

    (Johns Hopkins Bloomberg School of Public Health
    University of Freiburg)

  • Pamela R. Matias-Garcia

    (German Research Center for Environmental Health
    Helmholtz Zentrum München, German Research Center for Environmental Health
    Technical University of Munich)

  • Chris H. L. Thio

    (University of Groningen, University Medical Center Groningen)

  • Roby Joehanes

    (Framingham Heart Study
    National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Hongbo Liu

    (University of Pennsylvania Perelman School of Medicine)

  • Zhi Yu

    (Program in Medical and Population Genetics, Broad Institute
    Massachusetts General Hospital
    Massachusetts General Hospital)

  • Antoine Weihs

    (University Medicine Greifswald)

  • Anselm Hoppmann

    (University of Freiburg)

  • Franziska Grundner-Culemann

    (University of Freiburg)

  • Josine L. Min

    (University of Bristol
    Bristol Medical School, University of Bristol)

  • Victoria L. Halperin Kuhns

    (University of Maryland School of Medicine)

  • Adebowale A. Adeyemo

    (National Human Genome Research Institute, National Institutes of Health)

  • Charles Agyemang

    (University of Amsterdam)

  • Johan Ärnlöv

    (Karolinska Institutet
    Dalarna University)

  • Nasir A. Aziz

    (German Centre for Neurodegenerative Diseases (DZNE)
    University of Bonn)

  • Andrea Baccarelli

    (Columbia University)

  • Murielle Bochud

    (University of Lausanne)

  • Hermann Brenner

    (Division of Clinical Epidemiology and Aging Research
    Heidelberg University
    German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
    German Cancer Research Center (DKFZ))

  • Jan Bressler

    (School of Public Health, The University of Texas Health Science Center at Houston)

  • Monique M. B. Breteler

    (German Centre for Neurodegenerative Diseases (DZNE)
    University of Bonn)

  • Cristian Carmeli

    (University of Lausanne
    University of Fribourg)

  • Layal Chaker

    (Erasmus University Medical Center
    Erasmus Medical Center)

  • Josef Coresh

    (Johns Hopkins Bloomberg School of Public Health)

  • Tanguy Corre

    (University of Lausanne)

  • Adolfo Correa

    (University of Mississippi Medical Center)

  • Simon R. Cox

    (The University of Edinburgh)

  • Graciela E. Delgado

    (Heidelberg University)

  • Kai-Uwe Eckardt

    (University of Erlangen-Nürnberg
    Charité – Universitätsmedizin Berlin)

  • Arif B. Ekici

    (Friedrich-Alexander-UniversitätErlangen-Nürnberg)

  • Karlhans Endlich

    (University Medicine Greifswald
    Partner Site Greifswald)

  • James S. Floyd

    (University of Washington
    University of Washington
    University of Washington)

  • Eliza Fraszczyk

    (University of Groningen, University Medical Center Groningen)

  • Xu Gao

    (Columbia University
    Peking University)

  • Xīn Gào

    (Division of Clinical Epidemiology and Aging Research)

  • Allan C. Gelber

    (Johns Hopkins Bloomberg School of Public Health
    Johns Hopkins School of Medicine)

  • Mohsen Ghanbari

    (Erasmus University Medical Center)

  • Sahar Ghasemi

    (University Medicine Greifswald
    Partner Site Greifswald
    University Medicine Greifswald)

  • Christian Gieger

    (German Research Center for Environmental Health
    Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Philip Greenland

    (Northwestern University Feinberg School of Medicine)

  • Megan L. Grove

    (School of Public Health, The University of Texas Health Science Center at Houston)

  • Sarah E. Harris

    (The University of Edinburgh)

  • Gibran Hemani

    (University of Bristol
    Bristol Medical School, University of Bristol)

  • Peter Henneman

    (University of Amsterdam)

  • Christian Herder

    (Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf
    German Center for Diabetes Research
    Heinrich Heine University Düsseldorf)

  • Steve Horvath

    (University of California Los Angeles
    Biostatistics, Fielding School of Public Health, UCLA)

  • Lifang Hou

    (Northwestern University Feinberg School of Medicine)

  • Mikko A. Hurme

    (Tampere University)

  • Shih-Jen Hwang

    (Framingham Heart Study
    National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Sharon L. R. Kardia

    (University of Michigan)

  • Silva Kasela

    (University of Tartu)

  • Marcus E. Kleber

    (Heidelberg University
    SYNLAB MVZ Humangenetik Mannheim)

  • Wolfgang Koenig

    (Technische Universität München
    Partner site Munich Heart Alliance
    University of Ulm)

  • Jaspal S. Kooner

    (Imperial College London
    London North West Healthcare NHS Trust
    Imperial College Healthcare NHS Trust)

  • Florian Kronenberg

    (Medical University of Innsbruck)

  • Brigitte Kühnel

    (German Research Center for Environmental Health
    Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Christine Ladd-Acosta

    (Johns Hopkins Bloomberg School of Public Health)

  • Terho Lehtimäki

    (Tampere University
    Tampere University
    Fimlab Laboratories)

  • Lars Lind

    (Uppsala University)

  • Dan Liu

    (German Centre for Neurodegenerative Diseases (DZNE))

  • Donald M. Lloyd-Jones

    (Northwestern University Feinberg School of Medicine)

  • Stefan Lorkowski

    (Friedrich Schiller University Jena
    Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig)

  • Ake T. Lu

    (University of California Los Angeles)

  • Riccardo E. Marioni

    (University of Edinburgh)

  • Winfried März

    (Heidelberg University
    Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig
    Synlab Academy, SYNLAB Holding Deutschland GmbH
    Medical University of Graz)

  • Daniel L. McCartney

    (University of Edinburgh)

  • Karlijn A. C. Meeks

    (National Human Genome Research Institute, National Institutes of Health
    University of Amsterdam)

  • Lili Milani

    (University of Tartu)

  • Pashupati P. Mishra

    (Tampere University
    Tampere University
    Fimlab Laboratories)

  • Matthias Nauck

    (Partner Site Greifswald
    University Medicine Greifswald)

  • Christoph Nowak

    (Karolinska Institutet)

  • Annette Peters

    (Helmholtz Zentrum München, German Research Center for Environmental Health
    Ludwig-Maximilians Universität München)

  • Holger Prokisch

    (Klinikum rechts der Isar, Technische Universität München
    Helmholtz Zentrum München)

  • Bruce M. Psaty

    (University of Washington
    University of Washington
    University of Washington
    University of Washington)

  • Olli T. Raitakari

    (University of Turku
    Turku University Hospital
    University of Turku and Turku University Hospital)

  • Scott M. Ratliff

    (University of Michigan)

  • Alex P. Reiner

    (University of Washington)

  • Ben Schöttker

    (Division of Clinical Epidemiology and Aging Research
    Heidelberg University)

  • Joel Schwartz

    (Harvard T.H. Chan School of Public Health)

  • Sanaz Sedaghat

    (University of Minnesota)

  • Jennifer A. Smith

    (University of Michigan
    University of Michigan)

  • Nona Sotoodehnia

    (University of Washington)

  • Hannah R. Stocker

    (Division of Clinical Epidemiology and Aging Research
    Heidelberg University)

  • Silvia Stringhini

    (University of Lausanne)

  • Johan Sundström

    (Uppsala University
    University of New South Wales)

  • Brenton R. Swenson

    (University of Washington
    University of Washington)

  • Joyce B. J. Meurs

    (Erasmus Medical Center)

  • Jana V. Vliet-Ostaptchouk

    (University of Groningen, University Medical Center Groningen)

  • Andrea Venema

    (University of Amsterdam)

  • Uwe Völker

    (Partner Site Greifswald
    University Medicine Greifswald)

  • Juliane Winkelmann

    (Klinikum rechts der Isar, Technische Universität München
    Helmholtz Zentrum München
    Technische Universität München
    Munich Cluster for Systems Neurology (SyNergy))

  • Bruce H. R. Wolffenbuttel

    (University of Groningen, University Medical Center Groningen)

  • Wei Zhao

    (University of Michigan)

  • Yinan Zheng

    (Northwestern University Feinberg School of Medicine)

  • Marie Loh

    (Nanyang Technological University
    Imperial College London)

  • Harold Snieder

    (University of Groningen, University Medical Center Groningen)

  • Melanie Waldenberger

    (German Research Center for Environmental Health
    Helmholtz Zentrum München, German Research Center for Environmental Health
    Partner site Munich Heart Alliance)

  • Daniel Levy

    (Framingham Heart Study
    National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Shreeram Akilesh

    (University of Washington)

  • Owen M. Woodward

    (University of Maryland School of Medicine)

  • Katalin Susztak

    (University of Pennsylvania Perelman School of Medicine)

  • Alexander Teumer

    (Partner Site Greifswald
    University Medicine Greifswald
    Medical University of Bialystok)

  • Anna Köttgen

    (Johns Hopkins Bloomberg School of Public Health
    University of Freiburg)

Abstract

Elevated serum urate levels, a complex trait and major risk factor for incident gout, are correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures genetic and environmental influences and is assessed in transethnic meta-analysis of epigenome-wide association studies (EWAS) of serum urate (discovery, n = 12,474, replication, n = 5522). The 100 replicated, epigenome-wide significant (p

Suggested Citation

  • Adrienne Tin & Pascal Schlosser & Pamela R. Matias-Garcia & Chris H. L. Thio & Roby Joehanes & Hongbo Liu & Zhi Yu & Antoine Weihs & Anselm Hoppmann & Franziska Grundner-Culemann & Josine L. Min & Vic, 2021. "Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27198-4
    DOI: 10.1038/s41467-021-27198-4
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    1. Laura J. Smyth & Emma H. Dahlström & Anna Syreeni & Katie Kerr & Jill Kilner & Ross Doyle & Eoin Brennan & Viji Nair & Damian Fermin & Robert G. Nelson & Helen C. Looker & Christopher Wooster & Darrel, 2022. "Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Thomas Battram & Tom R. Gaunt & Caroline L. Relton & Nicholas J. Timpson & Gibran Hemani, 2022. "A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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