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Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Author

Listed:
  • Linda Judák

    (Institute of Experimental Medicine)

  • Balázs Chiovini

    (Institute of Experimental Medicine
    Pázmány Péter University)

  • Gábor Juhász

    (Pázmány Péter University)

  • Dénes Pálfi

    (Institute of Experimental Medicine
    Pázmány Péter University)

  • Zsolt Mezriczky

    (Pázmány Péter University)

  • Zoltán Szadai

    (Institute of Experimental Medicine)

  • Gergely Katona

    (Pázmány Péter University)

  • Benedek Szmola

    (Pázmány Péter University)

  • Katalin Ócsai

    (Pázmány Péter University)

  • Bernadett Martinecz

    (Institute of Experimental Medicine)

  • Anna Mihály

    (Pázmány Péter University)

  • Ádám Dénes

    (Institute of Experimental Medicine)

  • Bálint Kerekes

    (Pázmány Péter University
    Research Centre for Natural Sciences)

  • Áron Szepesi

    (Institute of Experimental Medicine)

  • Gergely Szalay

    (Institute of Experimental Medicine)

  • István Ulbert

    (Pázmány Péter University
    Research Centre for Natural Sciences)

  • Zoltán Mucsi

    (BrainVisionCenter)

  • Botond Roska

    (BrainVisionCenter
    Institute of Molecular and Clinical Ophthalmology Basel
    Friedrich Miescher Institute
    University of Basel)

  • Balázs Rózsa

    (Institute of Experimental Medicine
    Pázmány Péter University
    BrainVisionCenter)

Abstract

Neuronal plasticity has been shown to be causally linked to coincidence detection through dendritic spikes (dSpikes). We demonstrate the existence of SPW-R-associated, branch-specific, local dSpikes and their computational role in basal dendrites of hippocampal PV+ interneurons in awake animals. To measure the entire dendritic arbor of long thin dendrites during SPW-Rs, we used fast 3D acousto-optical imaging through an eccentric deep-brain adapter and ipsilateral local field potential recording. The regenerative calcium spike started at variable, NMDA-AMPA-dependent, hot spots and propagated in both direction with a high amplitude beyond a critical distance threshold (~150 µm) involving voltage-gated calcium channels. A supralinear dendritic summation emerged during SPW-R doublets when two successive SPW-R events coincide within a short temporal window (~150 ms), e.g., during more complex association tasks, and generated large dSpikes with an about 2.5-3-fold amplitude increase which propagated down to the soma. Our results suggest that these doublet-associated dSpikes can work as a dendritic-level temporal and spatial coincidence detector during SPW-R-related network computation in awake mice.

Suggested Citation

  • Linda Judák & Balázs Chiovini & Gábor Juhász & Dénes Pálfi & Zsolt Mezriczky & Zoltán Szadai & Gergely Katona & Benedek Szmola & Katalin Ócsai & Bernadett Martinecz & Anna Mihály & Ádám Dénes & Bálint, 2022. "Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34520-1
    DOI: 10.1038/s41467-022-34520-1
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    References listed on IDEAS

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