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NMDA spikes in basal dendrites of cortical pyramidal neurons

Author

Listed:
  • Jackie Schiller

    (Departments of Physiology and Biophysics Technion Medical School)

  • Guy Major

    (Biological Computation Research-Bell Laboratories, Lucent Technologies
    University Laboratory of Physiology)

  • Helmut J. Koester

    (Max-Planck-Institute for Medical Research)

  • Yitzhak Schiller

    (Rambam Medical Center)

Abstract

Basal dendrites are a major target for synaptic inputs innervating cortical pyramidal neurons1. At present little is known about signal processing in these fine dendrites. Here we show that co-activation of clustered neighbouring basal inputs initiated local dendritic spikes, which resulted in a 5.9 ± 1.5 mV (peak) and 64.4 ± 19.8 ms (half-width) cable-filtered voltage change at the soma that amplified the somatic voltage response by 226 ± 46%. These spikes were accompanied by large calcium transients restricted to the activated dendritic segment. In contrast to conventional sodium or calcium spikes, these spikes were mediated mostly by NMDA (N -methyl-D-aspartate) receptor channels, which contributed at least 80% of the total charge. The ionic mechanism of these NMDA spikes may allow ‘dynamic spike-initiation zones’, set by the spatial distribution of glutamate pre-bound to NMDA receptors, which in turn would depend on recent and ongoing activity in the cortical network. In addition, NMDA spikes may serve as a powerful mechanism for modification of the cortical network by inducing long-term strengthening of co-activated neighbouring inputs.

Suggested Citation

  • Jackie Schiller & Guy Major & Helmut J. Koester & Yitzhak Schiller, 2000. "NMDA spikes in basal dendrites of cortical pyramidal neurons," Nature, Nature, vol. 404(6775), pages 285-289, March.
    • Handle: RePEc:nat:nature:v:404:y:2000:i:6775:d:10.1038_35005094
    DOI: 10.1038/35005094
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    Citations

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    Cited by:

    1. Romain Daniel Cazé & Mark Humphries & Boris Gutkin, 2013. "Passive Dendrites Enable Single Neurons to Compute Linearly Non-separable Functions," PLOS Computational Biology, Public Library of Science, vol. 9(2), pages 1-15, February.
    2. Linda Judák & Balázs Chiovini & Gábor Juhász & Dénes Pálfi & Zsolt Mezriczky & Zoltán Szadai & Gergely Katona & Benedek Szmola & Katalin Ócsai & Bernadett Martinecz & Anna Mihály & Ádám Dénes & Bálint, 2022. "Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Etay Hay & Sean Hill & Felix Schürmann & Henry Markram & Idan Segev, 2011. "Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties," PLOS Computational Biology, Public Library of Science, vol. 7(7), pages 1-18, July.
    4. Matteo Farinella & Daniel T Ruedt & Padraig Gleeson & Frederic Lanore & R Angus Silver, 2014. "Glutamate-Bound NMDARs Arising from In Vivo-like Network Activity Extend Spatio-temporal Integration in a L5 Cortical Pyramidal Cell Model," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-21, April.
    5. Thomas E. Chater & Maximilian F. Eggl & Yukiko Goda & Tatjana Tchumatchenko, 2024. "Competitive processes shape multi-synapse plasticity along dendritic segments," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Hang Zhou & Guo-Qiang Bi & Guosong Liu, 2024. "Intracellular magnesium optimizes transmission efficiency and plasticity of hippocampal synapses by reconfiguring their connectivity," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    7. David M Santucci & Sridhar Raghavachari, 2008. "The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation," PLOS Computational Biology, Public Library of Science, vol. 4(10), pages 1-16, October.
    8. Balázs Ujfalussy & Tamás Kiss & Péter Érdi, 2009. "Parallel Computational Subunits in Dentate Granule Cells Generate Multiple Place Fields," PLOS Computational Biology, Public Library of Science, vol. 5(9), pages 1-16, September.
    9. Kirsten Bohmbach & Nicola Masala & Eva M. Schönhense & Katharina Hill & André N. Haubrich & Andreas Zimmer & Thoralf Opitz & Heinz Beck & Christian Henneberger, 2022. "An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    10. Vardi, Roni & Tugendhaft, Yael & Kanter, Ido, 2023. "Neuronal plasticity features are independent of neuronal holding membrane potential," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 632(P1).

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