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Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo

Author

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  • Spencer L. Smith

    (Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    University of North Carolina School of Medicine)

  • Ikuko T. Smith

    (Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    University of North Carolina School of Medicine)

  • Tiago Branco

    (Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 0QH, UK)

  • Michael Häusser

    (Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK)

Abstract

Neuronal dendrites are not passive cables, but whether their excitability contributes to computation at the cell’s soma has been uncertain; by observing and interfering with dendritic ‘spikes’ during sensory stimulation, it is now shown that active dendritic processing enhances somatic orientation selectivity, a fundamental brain computation.

Suggested Citation

  • Spencer L. Smith & Ikuko T. Smith & Tiago Branco & Michael Häusser, 2013. "Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo," Nature, Nature, vol. 503(7474), pages 115-120, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7474:d:10.1038_nature12600
    DOI: 10.1038/nature12600
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    Cited by:

    1. Zhenrui Liao & Kevin C. Gonzalez & Deborah M. Li & Catalina M. Yang & Donald Holder & Natalie E. McClain & Guofeng Zhang & Stephen W. Evans & Mariya Chavarha & Jane Simko & Christopher D. Makinson & M, 2024. "Functional architecture of intracellular oscillations in hippocampal dendrites," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Yichen Zhang & Gan He & Lei Ma & Xiaofei Liu & J. J. Johannes Hjorth & Alexander Kozlov & Yutao He & Shenjian Zhang & Jeanette Hellgren Kotaleski & Yonghong Tian & Sten Grillner & Kai Du & Tiejun Huan, 2023. "A GPU-based computational framework that bridges neuron simulation and artificial intelligence," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Hang Zhou & Guo-Qiang Bi & Guosong Liu, 2024. "Intracellular magnesium optimizes transmission efficiency and plasticity of hippocampal synapses by reconfiguring their connectivity," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Stefano Recanatesi & Gabriel Koch Ocker & Michael A Buice & Eric Shea-Brown, 2019. "Dimensionality in recurrent spiking networks: Global trends in activity and local origins in connectivity," PLOS Computational Biology, Public Library of Science, vol. 15(7), pages 1-29, July.
    5. Linda Judák & Balázs Chiovini & Gábor Juhász & Dénes Pálfi & Zsolt Mezriczky & Zoltán Szadai & Gergely Katona & Benedek Szmola & Katalin Ócsai & Bernadett Martinecz & Anna Mihály & Ádám Dénes & Bálint, 2022. "Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    6. Matteo Farinella & Daniel T Ruedt & Padraig Gleeson & Frederic Lanore & R Angus Silver, 2014. "Glutamate-Bound NMDARs Arising from In Vivo-like Network Activity Extend Spatio-temporal Integration in a L5 Cortical Pyramidal Cell Model," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-21, April.

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